(Q35592537)

English

The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions

scientific article published on 21 April 2015

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Plasmodium falciparum

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Margaret A. Phillips

4

object named as

Margaret A Phillips

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Pradipsinh K. Rathod

3

object named as

Pradipsinh K Rathod

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

author name string

Xiaoyi Deng

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

David Matthews

2

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Europe PubMed Central

PubMed publication ID

9 August 2017

language of work or name

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publication date

21 April 2015

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Europe PubMed Central

PubMed publication ID

9 August 2017

Acta crystallographica. Section F, Structural biology communications

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Europe PubMed Central

PubMed publication ID

9 August 2017

71

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Europe PubMed Central

PubMed publication ID

9 August 2017

Pt 5

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

553-559

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Spread of artemisinin resistance in Plasmodium falciparum malaria

1 reference

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12 July 2018

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

1 reference

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12 July 2018

Novel inhibitors of the Plasmodium falciparum electron transport chain

1 reference

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12 July 2018

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

1 reference

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12 July 2018

Antimalarial drug discovery - the path towards eradication.

1 reference

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12 July 2018

Designing the next generation of medicines for malaria control and eradication

1 reference

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12 July 2018

On dihydroorotate dehydrogenases and their inhibitors and uses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Malaria biology and disease pathogenesis: insights for new treatments

1 reference

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12 July 2018

The global pipeline of new medicines for the control and elimination of malaria

1 reference

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12 July 2018

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Linking Crystallographic Model and Data Quality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

1-Chloro-2-methyl-3-nitro-benzene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

REFMAC5 for the refinement of macromolecular crystal structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

The role of anti-malarial drugs in eliminating malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Solving structures of protein complexes by molecular replacement with Phaser

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Halogen bonds in biological molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

Automated refinement of protein models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

26 September 2018

Artemisinin resistance is a clear and present danger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

26 September 2018

Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427164

26 September 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/25945708

12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.1107/S2053230X15000989

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

ResearchGate publication ID

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