(Q35071496)

English

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Plasmodium falciparum

0 references

0 references

10

object named as

Jeremy Burrows

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Margaret A. Phillips

15

object named as

Margaret A Phillips

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Pradipsinh K. Rathod

16

object named as

Pradipsinh K Rathod

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Frederick S Buckner

13

object named as

Frederick S Buckner

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

William N. Charman

8

object named as

William N Charman

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Susan A. Charman

14

object named as

Susan A Charman

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

9

object named as

Ian Bathurst

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Farah El Mazouni

2

object named as

Farah El Mazouni

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

David M Shackleford

6

object named as

David M Shackleford

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

3

object named as

Karen L White

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

1

object named as

Ramesh Gujjar

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Sharon A Creason

5

object named as

Sharon Creason

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

author name string

Xiaoyi Deng

7

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

David M Floyd

11

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

David Matthews

12

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

John White

4

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

language of work or name

0 references

publication date

12 May 2011

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

54

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

3935-3949

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Shrinking the malaria map: progress and prospects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Chemical genetics of Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

The selection landscape of malaria parasites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N'6'-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Artemisinin resistance: current status and scenarios for containment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

New medicines to improve control and contribute to the eradication of malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Artemisinin Resistance in Plasmodium falciparum Malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Mitochondrial evolution and functions in malaria parasites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

The global portfolio of new antimalarial medicines under development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Malaria: progress, perils, and prospects for eradication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Antimalarial drug discovery: efficacy models for compound screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Antimalarial drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Insights into antifolate resistance from malarial DHFR-TS structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

8 July 2018

Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

27 September 2018

Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124361

27 September 2018

Physiological parameters in laboratory animals and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/21517059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM200265B

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q35071496&oldid=1743540681"