(Q35600122)

9 August 2017

title

Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response (English)

1 reference

Elizabeth Cohen-Jonathan Moyal

9 August 2017

1 reference

1 reference

Anthony Lemarié

6

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10

object named as

Elizabeth Cohen-Jonathan Moyal

1 reference

9 August 2017

8

Henry Brem

1 reference

9 August 2017

Julie Sesen

1

1 reference

9 August 2017

Perrine Dahan

2

1 reference

9 August 2017

Sarah J Scotland

3

1 reference

9 August 2017

Estelle Saland

4

1 reference

9 August 2017

Van-Thi Dang

5

1 reference

9 August 2017

Betty M Tyler

7

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9 August 2017

Christine Toulas

9

1 reference

9 August 2017

Jean-Emmanuel Sarry

11

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9 August 2017

Nicolas Skuli

12

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9 August 2017

language of work or name

English

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publication date

13 April 2015

1 reference

9 August 2017

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9 August 2017

volume

10

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9 August 2017

issue

4

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9 August 2017

page(s)

e0123721

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Creative Commons Attribution 4.0 International

9 August 2017

copyright license

start time

13 April 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4395104/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Metformin plus sorafenib highly impacts temozolomide resistant glioblastoma stem-like cells

12 July 2018

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Effect of metformin on the human T98G glioblastoma multiforme cell line

12 July 2018

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Radiosensitization of pancreatic cancer cells by metformin through the AMPK pathway

12 July 2018

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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

12 July 2018

1 reference

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Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling

12 July 2018

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New molecules and old drugs as emerging approaches to selectively target human glioblastoma cancer stem cells

12 July 2018

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Int6/eIF3e is essential for proliferation and survival of human glioblastoma cells.

12 July 2018

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12 July 2018

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Effects of metformin on CD133+ colorectal cancer cells in diabetic patients

12 July 2018

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Characterization of the stem cell niche and its importance in radiobiological response

12 July 2018

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Potential applications for biguanides in oncology

12 July 2018

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Glioblastoma: from molecular pathology to targeted treatment

12 July 2018

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Metformin inhibits glioma cell U251 invasion by downregulation of fibulin-3.

12 July 2018

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Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK.

12 July 2018

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Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells.

12 July 2018

1 reference

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Metformin inhibits the growth of human pancreatic cancer xenografts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt.

12 July 2018

1 reference

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Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK.

12 July 2018

1 reference

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Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end?

12 July 2018

1 reference

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Investigating metformin for cancer prevention and treatment: the end of the beginning

12 July 2018

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12 July 2018

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Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells

12 July 2018

1 reference

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Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

12 July 2018

1 reference

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Metformin plus temozolomide-based chemotherapy as adjuvant treatment for WHO grade III and IV malignant gliomas.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis

12 July 2018

1 reference

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Antidiabetic pharmacology: a link between metabolic syndrome and neuro-oncology?

12 July 2018

1 reference

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AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.

12 July 2018

1 reference

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Feedback control of p53 translation by REDD1 and mTORC1 limits the p53-dependent DNA damage response

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Targeting cancer metabolism: a therapeutic window opens

12 July 2018

1 reference

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In vitro and in vivo anti-melanoma action of metformin.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Neurological adverse effects caused by cytotoxic and targeted therapies.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Mutations in the heme b-binding residue of SDHC inhibit assembly of respiratory chain complex II in mammalian cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

The paradox of autophagy and its implication in cancer etiology and therapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Metformin therapy and clinical uses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Tumor cell metabolism: cancer's Achilles' heel

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Regulation of mTOR and cell growth in response to energy stress by REDD1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Understanding and targeting alkylator resistance in glioblastoma.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Glioblastoma stem cells: a new target for metformin and arsenic trioxide.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4395104

The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25867026

12 December 2020

inferred from PubMed ID database lookup

Spectrophotometric Assay for Complex I of the Respiratory Chain in Tissue Samples and Cultured Fibroblasts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25867026

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1371/JOURNAL.PONE.0123721

1 reference

release_k5vx2gicabfgrps5aswopdwclu

9 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/k5vx2gicabfgrps5aswopdwclu

24 November 2022

mapped directly with Wikidata item

PMC publication ID

4395104

1 reference

9 August 2017

1 reference