(Q35628619)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722654%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

review article

1 reference

title

Modulation of insulin action (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722654%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722654%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

author name string

A M Johnston

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722654%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

E Van Obberghen

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722654%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

publication date

13 January 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722654%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722654%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

volume

47

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722654%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

page(s)

170-184

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722654%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722654%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s00125-003-1313-3

17 November 2019

exact match

0 references

cites work

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

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12 December 2020

Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus.

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12 December 2020

Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus

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12 December 2020

Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients

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12 December 2020

Glucosamine-induced insulin resistance is coupled to O-linked glycosylation of Munc18c

1 reference

12 December 2020

Regulation of vascular endothelial growth factor expression by advanced glycation end products

1 reference

12 December 2020

14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation

1 reference

12 December 2020

The insulin signalling pathway

1 reference

12 December 2020

A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation

1 reference

12 December 2020

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors

1 reference

12 December 2020

Expression of insulin/IGF-I hybrid receptors is increased in skeletal muscle of patients with chronic primary hyperinsulinemia.

1 reference

12 December 2020

TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport

1 reference

12 December 2020

Advanced glycation endproducts and diabetic nephropathy

1 reference

12 December 2020

Insulin resistance due to mutations of the insulin receptor gene: an overview.

1 reference

12 December 2020

Inflammatory status and insulin resistance

1 reference

12 December 2020

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

1 reference

12 December 2020

SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice

1 reference

12 December 2020

Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport

1 reference

12 December 2020

Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice.

1 reference

12 December 2020

Insulin-regulated gene expression

1 reference

12 December 2020

Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance

1 reference

12 December 2020

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

1 reference

12 December 2020

Defective regulation of phosphatidylinositol-3-kinase gene expression in skeletal muscle and adipose tissue of non-insulin-dependent diabetes mellitus patients

1 reference

12 December 2020

Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN β‐cell line and human islets of Langerhans

1 reference

12 December 2020

Interleukin-6 induces cellular insulin resistance in hepatocytes

1 reference

12 December 2020

Increased expression of the SNARE accessory protein Munc18c in lipid-mediated insulin resistance

1 reference

12 December 2020

Short-term glucosamine infusion does not affect insulin sensitivity in humans

1 reference

12 December 2020

Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways

1 reference

12 December 2020

CAP defines a second signalling pathway required for insulin-stimulated glucose transport

1 reference

12 December 2020

Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress

1 reference

12 December 2020

Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1)

1 reference

12 December 2020

Prevention of fat-induced insulin resistance by salicylate

1 reference

12 December 2020

Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism

1 reference

12 December 2020

The PI3K-PDK1 connection: more than just a road to PKB

1 reference

12 December 2020

Protein tyrosine phosphatases: the quest for negative regulators of insulin action

1 reference

12 December 2020

A central role for JNK in obesity and insulin resistance

1 reference

12 December 2020

Dietary fat, the Mediterranean diet, and health: reports from scientific exchanges, 1998 and 2000. Introduction

1 reference

12 December 2020

Targeting I kappa B kinase for the treatment of inflammatory and other disorders

1 reference

12 December 2020

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

1 reference

12 December 2020

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes

1 reference

12 December 2020

Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

1 reference

12 December 2020

Hyperglycemia impairs the insulin signaling step between PI 3-kinase and Akt/PKB activations in ZDF rat liver

1 reference

12 December 2020

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1 reference

12 December 2020

A family of cytokine-inducible inhibitors of signalling

1 reference

12 December 2020

Abnormal glucose transport and GLUT1 cell-surface content in fibroblasts and skeletal muscle from NIDDM and obese subjects.

1 reference

12 December 2020

14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain

1 reference

12 December 2020

Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.

1 reference

12 December 2020

Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM.

1 reference

12 December 2020

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

1 reference

12 December 2020

Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

1 reference

12 December 2020

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

1 reference

12 December 2020

Identification of enhanced serine kinase activity in insulin resistance

1 reference

12 December 2020

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

1 reference

12 December 2020

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

1 reference

12 December 2020

Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance

1 reference

12 December 2020

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

1 reference

12 December 2020

Advanced glycation end-products: a review

1 reference

12 December 2020

Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

1 reference

12 December 2020

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance

1 reference

12 December 2020

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

1 reference

12 December 2020

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

12 December 2020

Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes

1 reference

12 December 2020

High Glucose-Induced Expression of Proinflammatory Cytokine and Chemokine Genes in Monocytic Cells

1 reference

12 December 2020

Increased abundance of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of obese subjects is correlated with in vivo insulin sensitivity

1 reference

12 December 2020

Tumor necrosis factor alpha: a key component of the obesity-diabetes link

1 reference

12 December 2020

Pigment epithelium-derived factor prevents advanced glycation end products-induced monocyte chemoattractant protein-1 production in microvascular endothelial cells by suppressing intracellular reactive oxygen species generation

1 reference

12 December 2020

Clinical review 125: The insulin receptor and its cellular targets

1 reference

12 December 2020

Glucosamine regulation of glucose metabolism in cultured human skeletal muscle cells: divergent effects on glucose transport/phosphorylation and glycogen synthase in non-diabetic and type 2 diabetic subjects

1 reference

12 December 2020

Insulin signalling and the regulation of glucose and lipid metabolism

1 reference

12 December 2020

Insulin Induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 Skeletal Muscle Cells Is Mediated by Stat5*.

1 reference

12 December 2020

Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity

1 reference

12 December 2020

14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1.

1 reference

12 December 2020

Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities

1 reference

12 December 2020

Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor

1 reference

12 December 2020

AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes

1 reference

12 December 2020

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

12 December 2020

Serine phosphorylation of insulin receptor substrate-1: a novel target for the reversal of insulin resistance.

1 reference

12 December 2020

A new role for SOCS in insulin action. Suppressor of cytokine signaling

1 reference

12 December 2020

Suppressors of cytokine signalling (SOCS) in the immune system

1 reference

12 December 2020

Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice

1 reference

12 December 2020

Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance.

1 reference

12 December 2020

A rho-associated protein kinase, ROKalpha, binds insulin receptor substrate-1 and modulates insulin signaling.

1 reference

12 December 2020

N-3 polyunsaturated fatty acids prevent the defect of insulin receptor signaling in muscle.

1 reference

12 December 2020

The insulin receptor on the human lymphocyte: insulin-induced down-regulation of 126,000 and 90,000 glycosylated subunits

1 reference

12 December 2020

14-3-3beta protein associates with insulin receptor substrate 1 and decreases insulin-stimulated phosphatidylinositol 3'-kinase activity in 3T3L1 adipocytes

1 reference

12 December 2020

High glucose and insulin in combination cause insulin receptor substrate-1 and -2 depletion and protein kinase B desensitisation in primary cultured rat adipocytes: possible implications for insulin resistance in type 2 diabetes.

1 reference

12 December 2020

Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3.

1 reference

12 December 2020

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

1 reference

12 December 2020

Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

1 reference

12 December 2020

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

12 December 2020

Decreased insulin binding in cultured lymphocytes from two patients with extreme insulin resistance

1 reference

12 December 2020

Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.

1 reference

12 December 2020

Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation

1 reference

12 December 2020

Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases

1 reference

12 December 2020

Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity.

1 reference

12 December 2020

Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor

1 reference

12 December 2020

Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor

1 reference

12 December 2020

Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation

1 reference

12 December 2020

Apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes?

1 reference

12 December 2020

Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5

1 reference

12 December 2020

A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.

1 reference

12 December 2020

Glycation of insulin in the islets of Langerhans of normal and diabetic animals.

1 reference

12 December 2020

14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner

1 reference

12 December 2020

Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance

1 reference

12 December 2020

Growth modulation of retinal microvascular cells by early and advanced glycation products

1 reference

12 December 2020

Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.

1 reference

12 December 2020

Active Rho kinase (ROK-alpha ) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells.

1 reference

12 December 2020

Protein tyrosine phosphatase 1B: a novel target for type 2 diabetes and obesity

1 reference

12 December 2020

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

1 reference

12 December 2020

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

1 reference

12 December 2020

Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine:fructose-6-phosphate amidotransferase: decreased glucose transporter GLUT4 translocation and reversal by treatment with thiazolidinedione.

1 reference

12 December 2020

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

1 reference

12 December 2020

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

1 reference

12 December 2020

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin

1 reference

12 December 2020

Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice.

1 reference

12 December 2020

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

1 reference

12 December 2020

Demonstration of increased concentrations of circulating glycated insulin in human Type 2 diabetes using a novel and specific radioimmunoassay

1 reference

12 December 2020

Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells

1 reference

12 December 2020

Biochemical mechanisms of insulin resistance

1 reference

12 December 2020

Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study

1 reference

12 December 2020

Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity

1 reference

12 December 2020

Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes

1 reference

12 December 2020

Regulation of lipogenic enzyme gene expression by nutrients and hormones

1 reference

12 December 2020

Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in nonobese subjects with NIDDM.

1 reference

12 December 2020

The insulin signalling system and the IRS proteins

1 reference

12 December 2020

Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine.

1 reference

12 December 2020

Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function

1 reference

12 December 2020

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

1 reference

12 December 2020

Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2

1 reference

12 December 2020

Insulin stimulates the degradation of IRS-1 in 3T3-L1 adipocytes

1 reference

12 December 2020

Effects of overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT) and glucosamine treatment on translocation of GLUT4 in rat adipose cells

1 reference

12 December 2020

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

1 reference

12 December 2020

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

1 reference

12 December 2020

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

1 reference

12 December 2020

Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins

1 reference

12 December 2020

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

1 reference

12 December 2020

Ten years of protein kinase B signalling: a hard Akt to follow

1 reference

12 December 2020

Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities

1 reference

12 December 2020

5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside

1 reference

12 December 2020

The SOCS box: a tale of destruction and degradation

1 reference

12 December 2020

Inhibitory effect of hyperglycemia on insulin-induced Akt/protein kinase B activation in skeletal muscle

1 reference

12 December 2020

Wortmannin-sensitive pathway is required for insulin-stimulated phosphorylation of inhibitor kappaBalpha

1 reference

12 December 2020

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

1 reference

12 December 2020

Perspective: Hexosamines and nutrient sensing

1 reference

12 December 2020

Effects of glucosamine infusion on insulin secretion and insulin action in humans.

1 reference

12 December 2020

SOCS-3 is an insulin-induced negative regulator of insulin signaling

1 reference

12 December 2020

A role for nuclear factor kappaB in the antiapoptotic function of insulin

1 reference

12 December 2020

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

1 reference

12 December 2020

Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM.

1 reference

12 December 2020