(Q35646010)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

title

Design and synthesis of C6-C8 bridged epothilone A (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

5

Dennis C Liotta

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1

Weiqiang Zhan

1 reference

4 January 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

Yi Jiang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Peggy J Brodie

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

James P Snyder

series ordinal

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

language of work or name

English

0 references

publication date

21 March 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

page(s)

1565-1568

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization

4 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

The chemistry and biology of epothilones--the wheel keeps turning.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

Recent developments in the chemical biology of epothilones

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

Application of ring-closing metathesis reactions in the synthesis of epothilones

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

The biology and medicinal chemistry of epothilones

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

Conformation-activity relationships in polyketide natural products: a new perspective on the rational design of epothilone analogues

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

Much anticipated--the bioactive conformation of epothilone and its binding to tubulin

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

Intramolecular Diels-Alder reactions using alpha-methylene lactones as dienophile

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

The 12,13-diol cyclization approach for a truly stereocontrolled total synthesis of epothilone B and the synthesis of a conformationally restrained analogue

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

Cloning and heterologous expression of the epothilone gene cluster.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249659

SAR and pH stability of cyano-substituted epothilones

15 November 2018

1 reference

12 December 2020

Metal-catalyzed cycloisomerization of enyne functionalities via a 1,3-alkylidene migration

1 reference

12 December 2020

Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties

1 reference

12 December 2020

The B-Alkyl Suzuki-Miyaura Cross-Coupling Reaction: Development, Mechanistic Study, and Applications in Natural Product Synthesis A list of abbreviations can be found at the end of the article

1 reference

12 December 2020

Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

1 reference

9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/ANIE.199615671

Identifiers

DOI

10.1021/OL800422Q

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18355076%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

PubMed publication ID

18355076

1 reference