(Q45268286)

11 December 2017

title

Much anticipated--the bioactive conformation of epothilone and its binding to tubulin (English)

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11 December 2017

Dirk W Heinz

1

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11 December 2017

Wolf-Dieter Schubert

series ordinal

2

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11 December 2017

Gerhard Höfle

series ordinal

3

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11 December 2017

language of work or name

English

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publication date

1 February 2005

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Angewandte Chemie International Edition

11 December 2017

published in

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volume

44

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11 December 2017

issue

9

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11 December 2017

page(s)

1298-1301

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Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

11 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

Myxobacteria: proficient producers of novel natural products with various biological activities--past and future biotechnological aspects with the focus on the genus Sorangium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

Epothilones: mechanism of action and biologic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

Conformation-activity relationships in polyketide natural products. Towards the biologically active conformation of epothilone

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

A common pharmacophore for cytotoxic natural products that stabilize microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

Structure of the alpha beta tubulin dimer by electron crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

Refined structure of alpha beta-tubulin at 3.5 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

Conformation-activity relationships in polyketide natural products: a new perspective on the rational design of epothilone analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

A Common Pharmacophore for Taxol and the Epothilones Based on the Biological Activity of a Taxane Molecule Lacking a C-13 Side Chain†

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200462241

Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

21 January 2018

1 reference

9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/ANIE.199615671

Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.49.560

Identifiers

DOI

10.1002/ANIE.200462241

1 reference

11 December 2017

1 reference