(Q36752835)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17340668%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

review article

1 reference

title

The chemistry and biology of epothilones--the wheel keeps turning (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17340668%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17340668%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

author name string

Karl-Heinz Altmann

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17340668%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

Bernhard Pfeiffer

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17340668%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

Benjamin A Pratt

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17340668%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

K C Nicolaou

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17340668%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

publication date

1 April 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17340668%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17340668%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

volume

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17340668%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17340668%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

page(s)

396-423

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17340668%20AND%20SRC:MED&resulttype=core&format=json

Epothilones and the next generation of phase III trials for prostate cancer

26 December 2019

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7 January 2021

Antimitotic natural products and their interactions with tubulin

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7 January 2021

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

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7 January 2021

THE DEVELOPMENT AND CLINICAL UTILITY OF THE TAXANE CLASS OF ANTIMICROTUBULE CHEMOTHERAPY AGENTS

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7 January 2021

Promotion of microtubule assembly in vitro by taxol

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7 January 2021

The jerangolids: A family of new antifungal compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties of jerangolid A

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7 January 2021

New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies

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7 January 2021

A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus

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7 January 2021

Isolation and Characterization of New Epothilone Analogues from Recombinant Myxococcus xanthus Fermentations

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7 January 2021

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

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7 January 2021

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

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7 January 2021

Epothilon A und B – neuartige, 16gliedrige Makrolide mit cytotoxischer Wirkung: Isolierung, Struktur im Kristall und Konformation in Lösung

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7 January 2021

Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

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7 January 2021

Chemical Biology of Epothilones

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7 January 2021

Recent developments in the chemistry, biology and medicine of the epothilones

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7 January 2021

The merger of natural product synthesis and medicinal chemistry: on the chemistry and chemical biology of epothilones

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7 January 2021

The epothilones and related analogues-a review of their syntheses and anti-cancer activities

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7 January 2021

The biology and medicinal chemistry of epothilones

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7 January 2021

Epothilone B and its analogs - a new family of anticancer agents

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7 January 2021

Recent developments in the chemical biology of epothilones

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7 January 2021

The clinical development of new mitotic inhibitors that stabilize the microtubule

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7 January 2021

Development of novel chemotherapeutic agents to evade the mechanisms of multidrug resistance (MDR).

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7 January 2021

Review: tubulin function, action of antitubulin drugs, and new drug development

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7 January 2021

Patupilone (epothilone B, EPO906) inhibits growth and metastasis of experimental prostate tumors in vivo

1 reference

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7 January 2021

The epothilone dilemma

1 reference

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7 January 2021

Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors

1 reference

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7 January 2021

Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors

1 reference

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7 January 2021

Phase I clinical trial of BMS-247550, a derivative of epothilone B, using accelerated titration 2B design

1 reference

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7 January 2021

Evaluation of epothilone B analog in advanced soft tissue sarcoma: a phase II study of the phase II consortium.

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7 January 2021

A Phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days.

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7 January 2021

A retrospective evaluation of second-line chemotherapy response in hormone-refractory prostate carcinoma: second line taxane-based therapy after first-line epothilone-B analog ixabepilone (BMS-247550) therapy.

1 reference

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7 January 2021

Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.

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7 January 2021

Preclinical pharmacology of epothilone D, a novel tubulin-stabilizing antitumor agent.

1 reference

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7 January 2021

Preclinical pharmacokinetics and oral bioavailability of BMS-310705, a novel epothilone B analog

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7 January 2021

Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development.

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7 January 2021

Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits

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7 January 2021

Generation of new epothilones by genetic engineering of a polyketide synthase in Myxococcus xanthus

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7 January 2021

Heterologous production of epothilone C and D in Escherichia coli.

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7 January 2021

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

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7 January 2021

Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin

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7 January 2021

Novel molecules that interact with microtubules and have functional activity similar to Taxol

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7 January 2021

Epothilones: a novel class of non-taxane microtubule-stabilizing agents

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7 January 2021

The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site.

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7 January 2021

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography

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7 January 2021

Synthesis and biological evaluation of highly potent analogues of epothilones B and D.

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7 January 2021

Subcellular distribution of epothilones in human tumor cells

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7 January 2021

Mechanism of action of antitumor drugs that interact with microtubules and tubulin

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7 January 2021

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

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7 January 2021

Structure of the alpha beta tubulin dimer by electron crystallography

1 reference

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7 January 2021

A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence

1 reference

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7 January 2021

Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions

1 reference

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7 January 2021

Resistance to antimitotic agents as genetic probes of microtubule structure and function

1 reference

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7 January 2021

Total syntheses of epothilones B and d.

1 reference

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7 January 2021

Multi-Step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Total synthesis of 12,13-desoxyepothilone B (Epothilone D).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Studies towards the synthesis of epothilone A via organoboranes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Synthesis of epothilones via a silicon-tethered RCM reaction

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Total Synthesis of Epothilone A: The Olefin Metathesis Approach

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Synthesis of epothilones A and B in solid and solution phase

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7 January 2021

Totalsynthese von (—)-Epothilon A

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7 January 2021

Total Synthesis of(–)-Epothilone A

1 reference

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7 January 2021

Total Synthesis of(–)-Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones

1 reference

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7 January 2021

Total Synthesis of(−)-Epothilone A

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7 January 2021

How Stable Are Epoxides? A Novel Synthesis of Epothilone B

1 reference

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7 January 2021

The 12,13-diol cyclization approach for a truly stereocontrolled total synthesis of epothilone B and the synthesis of a conformationally restrained analogue

1 reference

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7 January 2021

Stereoselective total synthesis of epothilones by the metathesis approach involving C9-C10 bond formation

1 reference

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7 January 2021

Alkyne metathesis: development of a novel molybdenum-based catalyst system and its application to the total synthesis of epothilone A and C.

1 reference

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7 January 2021

Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490.

1 reference

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7 January 2021

Discovery of (E)-9,10-dehydroepothilones through chemical synthesis: on the emergence of 26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B as a promising anticancer drug candidate

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7 January 2021

Application of ring-closing metathesis reactions in the synthesis of epothilones

1 reference

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7 January 2021

Oxidative and reductive transformations of epothilone A

1 reference

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7 January 2021

Derivatization of the C12-C13 functional groups of epothilones A, B and C

1 reference

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7 January 2021

Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells

1 reference

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7 January 2021

A Novel Aldol Condensation with 2-Methyl-4-pentenal and Its Application to an Improved Total Synthesis of Epothilone B

1 reference

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7 January 2021

Synthesis, structure proof, and biological activity of epothilone cyclopropanes

1 reference

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7 January 2021

Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Design, synthesis, and biological properties of highly potent epothilone B analogues

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Selective grignard-type carbonyl addition of alkenyl halides mediated by chromium(II) chloride

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Catalytic effect of nickel(II) chloride and palladium(II) acetate on chromium(II)-mediated coupling reaction of iodo olefins with aldehydes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

An Efficient Asymmetric Epoxidation Method fortrans-Olefins Mediated by a Fructose-Derived Ketone

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

An Efficient Catalytic Asymmetric Epoxidation Method

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Antitumor efficacy of 26-fluoroepothilone B against human prostate cancer xenografts

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Total synthesis and biological evaluation of a C(10)/C(12)-phenylene-bridged analog of epothilone D

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

On the introduction of a trifluoromethyl substituent in the epothilone setting: chemical issues related to ring forming olefin metathesis and earliest biological findings

1 reference

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7 January 2021

Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Complex target-oriented total synthesis in the drug discovery process: the discovery of a highly promising family of second generation epothilones.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Synthesis and conformational analysis of (E)-9,10-dehydroepothilone B: a suggestive link between the chemistry and biology of epothilones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Design and Total Synthesis of a Superior Family of Epothilone Analogues, which Eliminate Xenograft Tumors to a Nonrelapsable State

1 reference

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7 January 2021

On the remarkable antitumor properties of fludelone: how we got there

1 reference

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7 January 2021

Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D.

1 reference

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7 January 2021

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

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7 January 2021

Therapeutic cure against human tumor xenografts in nude mice by a microtubule stabilization agent, fludelone, via parenteral or oral route

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7 January 2021

Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo.

1 reference

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7 January 2021

The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice

1 reference

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7 January 2021

On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: total synthesis and comparative in vivo evaluations of the 15-aza epothilones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Synthesis and biological evaluation of aza-epothilones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

SAR and pH stability of cyano-substituted epothilones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Scaffolds for microtubule inhibition through extensive modification of the epothilone template

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Chemical synthesis and biological properties of pyridine epothilones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Molecular design and chemical synthesis of a highly potent epothilone

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

C-15 thiazol-4-yl analogues of (E)-9,10-didehydroepothilone D: synthesis and cytotoxicity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Design, total synthesis, and evaluation of novel open-chain epothilone analogues

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

A common pharmacophore for cytotoxic natural products that stabilize microtubules

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

3D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600206

7 January 2021

Identifiers

DOI

10.1002/CMDC.200600206

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17340668%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

1 reference