(Q35677957)

9 August 2017

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title

PKR activation in neurodegenerative disease (English)

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9 August 2017

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Alyson L Peel

1

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9 August 2017

1 February 2004

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Journal of Neuropathology & Experimental Neurology

9 August 2017

9

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based on heuristic

inferred from page(s)

published in

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9 August 2017

63

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9 August 2017

2

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9 August 2017

97-105

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Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase

9 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

RNA binding and intramolecular interactions modulate the regulation of gene expression by nuclear factor 110

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Anti-apoptotic and oncogenic properties of the dsRNA-binding protein of vaccinia virus, E3L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Shutdown of translation: lethal or protective? Unfolded protein response versus apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

PKR; a sentinel kinase for cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Potential Alu function: regulation of the activity of double-stranded RNA-activated kinase PKR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Inhibition of the protein kinase PKR by the internal ribosome entry site of hepatitis C virus genomic RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Double-stranded RNA-independent dimerization of interferon-induced protein kinase PKR and inhibition of dimerization by the cellular P58IPK inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

The molecular chaperone hsp40 regulates the activity of P58IPK, the cellular inhibitor of PKR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

P52rIPK regulates the molecular cochaperone P58IPK to mediate control of the RNA-dependent protein kinase in response to cytoplasmic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-alpha receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Caspase 9 activation by the dsRNA-dependent protein kinase, PKR: molecular mechanism and relevance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Roles of nuclear factor kappaB in neuronal survival and plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

NF-kappaB in neuronal plasticity and neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Neuronal apoptosis induced by endoplasmic reticulum stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Stimulus-dependent activation of NF-kappaB specifies apoptosis or neuroprotection in cerebellar granule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKR

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Calcium mobilization by ryanodine promotes the phosphorylation of initiation factor 2alpha subunit and inhibits protein synthesis in cultured neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double-stranded RNA and encephalomyocarditis virus: involvement of RNase L, protein kinase R, and alternative pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Beta-amyloid of Alzheimer's disease activates an apoptotic pathway via caspase-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Activation of caspase-8 in the Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Analyzing the mechanisms of interferon-induced apoptosis using CrmA and hepatitis C virus NS5A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

Tissue specific expression of PKR protein kinase in aging B6D2F1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.2.97

21 January 2018

Identifiers

DOI

10.1093/JNEN/63.2.97

1 reference

9 August 2017

1 reference

PubMed ID

14989595