(Q35695799)

English

Successful inhibition of intracranial human glioblastoma multiforme xenograft growth via systemic adenoviral delivery of soluble endostatin and soluble vascular endothelial growth factor receptor-2: laboratory investigation

scientific article published on May 2008

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 August 2017

Successful inhibition of intracranial human glioblastoma multiforme xenograft growth via systemic adenoviral delivery of soluble endostatin and soluble vascular endothelial growth factor receptor-2: laboratory investigation (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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Judah Folkman

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9 August 2017

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Oszkar Szentirmai

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9 August 2017

Cheryl H Baker

2

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9 August 2017

Szofia S Bullain

3

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9 August 2017

Ning Lin

4

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9 August 2017

Masaya Takahashi

5

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9 August 2017

Richard C Mulligan

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Bob S Carter

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9 August 2017

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1 May 2008

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Journal of Neurosurgery

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9 August 2017

108

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9 August 2017

5

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9 August 2017

979-988

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9 August 2017

Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Current strategies and future directions for eluding adenoviral vector immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Mechanisms of angiogenesis in gliomas

1 reference

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12 July 2018

Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and antiangiogenic treatment effect

1 reference

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12 July 2018

Endostatin therapy reveals a U-shaped curve for antitumor activity

1 reference

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12 July 2018

Angiogenesis in gliomas: biology and molecular pathophysiology

1 reference

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12 July 2018

Plasminogen kringle 5-engineered glioma cells block migration of tumor-associated macrophages and suppress tumor vascularization and progression

1 reference

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12 July 2018

Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein

1 reference

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12 July 2018

Inhibitory effect of adeno-associated virus-mediated gene transfer of human endostatin on hepatocellular carcinoma

1 reference

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12 July 2018

Endogenous inhibitors of angiogenesis in malignant gliomas: nature's antiangiogenic therapy

1 reference

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

1 reference

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12 July 2018

Combined endostatin/sFlt-1 antiangiogenic gene therapy is highly effective in a rat model of HCC.

1 reference

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12 July 2018

Therapy of hematogenous melanoma brain metastases with endostatin.

1 reference

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12 July 2018

Gene therapy of brain tumor with endostatin.

1 reference

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12 July 2018

Anti-angiogenic effects of SN38 (active metabolite of irinotecan): inhibition of hypoxia-inducible factor 1 alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) expression of glioma and growth of endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Identification of human brain tumour initiating cells

1 reference

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12 July 2018

Antiangiogenic therapy by local intracerebral microinfusion improves treatment efficiency and survival in an orthotopic human glioblastoma model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Combined therapy with direct and indirect angiogenesis inhibition results in enhanced antiangiogenic and antitumor effects

1 reference

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12 July 2018

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Cell therapy using encapsulated cells producing endostatin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Time course of bioluminescent signal in orthotopic and heterotopic brain tumors in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Inhibition of metastatic brain tumor growth by intramuscular administration of the endostatin gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Therapeutic anti-angiogenesis for malignant brain tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Optimization for the blockade of epidermal growth factor receptor signaling for therapy of human pancreatic carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Antiangiogenesis -- therapeutic strategies and clinical implications for brain tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Local anti-angiogenic brain tumor therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Angiogenesis, metastasis, and endogenous inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Continuous release of endostatin from microencapsulated engineered cells for tumor therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Local endostatin treatment of gliomas administered by microencapsulated producer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Glioblastoma multiforme: the terminator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Simplified production of a recombinant human angiostatin derivative that suppresses intracerebral glial tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Vascular endothelial growth factor (VEGF) and its receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Regulation of angiogenesis in malignant gliomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

How tumors become angiogenic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Angiogenesis in malignant gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Vascular morphology and angiogenesis in glial tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Intratumor microvessel density as a prognostic factor in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

12 July 2018

Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis

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12 July 2018

Microvascular injury in pathogenesis of interferon-induced necrosis of subcutaneous tumors in mice.

1 reference

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12 July 2018

Brain tumors. Part 1.

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1 reference

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Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma

1 reference

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Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

25 September 2018

Inhibition of human nasopharyngeal carcinoma growth and metastasis in mice by adenovirus-associated virus-mediated expression of human endostatin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

25 September 2018

Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

25 September 2018

Antitumor efficacy improved by local delivery of species-specific endostatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

25 September 2018

Combinatorial antiangiogenic gene therapy by nonviral gene transfer using the sleeping beauty transposon causes tumor regression and improves survival in mice bearing intracranial human glioblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

25 September 2018

Angiogenesis and antiangiogenic therapy for malignant gliomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

25 September 2018

Intra-arterial delivery of endostatin gene to brain tumors prolongs survival and alters tumor vessel ultrastructure

1 reference

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1 reference

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25 September 2018

Antiangiogenic therapy against experimental glioblastoma using genetically engineered cells producing interferon-alpha, angiostatin, or endostatin

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

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Vascular patterns in glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins: evidence for distinct angiogenic subtypes.

1 reference

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1 reference

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1 reference

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25 September 2018

Increased levels of tissue endostatin in human malignant gliomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

25 September 2018

Antiangiogenic activity of endostatin inhibits C6 glioma growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

25 September 2018

Angiostatin K(1-3) gene for treatment of human gliomas: an experimental study.

1 reference

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25 September 2018

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25 September 2018

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1 reference

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25 September 2018

Localization of endostatin in rat and human gliomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

25 September 2018

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1 reference

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25 September 2018

Angiostatin suppresses malignant glioma growth in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

25 September 2018

Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

25 September 2018

Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459889

25 September 2018

Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. III. Inhibition of growth and necrosis of tumors implanted subcutaneously.

1 reference

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25 September 2018

PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization

1 reference

https://pubmed.ncbi.nlm.nih.gov/18447716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18447716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma

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https://pubmed.ncbi.nlm.nih.gov/18447716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous administration of endostatin by intraperitoneally implanted osmotic pump improves the efficacy and potency of therapy in a mouse xenograft tumor model

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https://pubmed.ncbi.nlm.nih.gov/18447716

12 December 2020

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inferred from PubMed ID database lookup

Correlation of vascular endothelial cell proliferation with microvessel density and expression of vascular endothelial growth factor and basic fibroblast growth factor in hepatocellular carcinoma

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https://pubmed.ncbi.nlm.nih.gov/18447716

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Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells

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https://pubmed.ncbi.nlm.nih.gov/18447716

12 December 2020

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Endostatin: are we waiting for Godot?

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https://pubmed.ncbi.nlm.nih.gov/18447716

12 December 2020

based on heuristic

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The polypeptides of adenovirus. II. Soluble proteins, cores, top components and the structure of the virion

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https://pubmed.ncbi.nlm.nih.gov/18447716

12 December 2020

based on heuristic

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Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18447716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12

1 reference

https://pubmed.ncbi.nlm.nih.gov/18447716

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3171/JNS/2008/108/5/0979

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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