(Q35705510)

25953765

9 August 2017

title

Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold (English)

1 reference

9 August 2017

0 references

1

1 reference

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11 June 2020

Marc Hafner

2

1 reference

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11 June 2020

Peter K. Sorger

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25953765%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Samuel Bandara

3

1 reference

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11 June 2020

Joshua J Sims

4

1 reference

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11 June 2020

Hannah Hudson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25953765%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Diana Chai

6

1 reference

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11 June 2020

publication date

7 May 2015

1 reference

25953765

Molecular Systems Biology

9 August 2017

published in

1 reference

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11 June 2020

volume

11

1 reference

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11 June 2020

issue

5

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11 June 2020

page(s)

803

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25953765%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

11 June 2020

HeLa ICRP

0 references

HeLa ICRP Bcl-2-mCherry

0 references

HeLa ICRP Bcl-XL-mCherry

0 references

HeLa ICRP FLIP-L-mCherry

0 references

HeLa ICRP FLIP-S-mCherry

0 references

cites work

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Death receptor agonist therapies for cancer, which is the right TRAIL?

27 July 2018

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Metrics other than potency reveal systematic variation in responses to cancer drugs.

27 July 2018

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Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes

27 July 2018

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27 July 2018

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On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

27 July 2018

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Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis

27 July 2018

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Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor necrosis factor-related apoptosis inducing ligand (TRAIL) signaling.

27 July 2018

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Measuring and modeling apoptosis in single cells

27 July 2018

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Targeting c-FLIP in cancer

27 July 2018

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Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL.

27 July 2018

1 reference

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New insights into apoptosis signaling by Apo2L/TRAIL.

27 July 2018

1 reference

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Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

27 July 2018

1 reference

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27 July 2018

The BCL-2 family reunion

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Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer

27 July 2018

1 reference

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Determinism and divergence of apoptosis susceptibility in mammalian cells

27 July 2018

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Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

27 July 2018

1 reference

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Quantitative analysis of pathways controlling extrinsic apoptosis in single cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Proteasome inhibition blocks caspase-8 degradation and sensitizes prostate cancer cells to death receptor-mediated apoptosis

27 July 2018

1 reference

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Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.

27 July 2018

1 reference

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BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

27 July 2018

1 reference

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TRAIL signalling: decisions between life and death.

27 July 2018

1 reference

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The apoptosome: signalling platform of cell death

27 July 2018

1 reference

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Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

27 July 2018

1 reference

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The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

27 July 2018

1 reference

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Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail

27 July 2018

1 reference

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HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo

27 July 2018

1 reference

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N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Interdimer processing mechanism of procaspase-8 activation.

27 July 2018

1 reference

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NF-kappa B as a therapeutic target in multiple myeloma

27 July 2018

1 reference

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Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

The role of c-FLIP in modulation of CD95-induced apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

An induced proximity model for caspase-8 activation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

X-linked IAP is a direct inhibitor of cell-death proteases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Regulating cell death at, on, and in membranes.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Bortezomib and TRAIL: a perfect match for apoptotic elimination of tumour cells?

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

A 71-gene signature of TRAIL sensitivity in cancer cells.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Apomab, a fully human agonistic antibody to DR5, exhibits potent antitumor activity against primary and metastatic breast cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Dynamics of outer mitochondrial membrane permeabilization during apoptosis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Modeling a snap-action, variable-delay switch controlling extrinsic cell death

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

The CD95 type I/type II model

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Two CD95 tumor classes with different sensitivities to antitumor drugs

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461398

Phase 1b Study of Dulanermin (recombinant human Apo2L/TRAIL) in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Patients With Advanced Non-Squamous Non–Small-Cell Lung Cancer

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25953765

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.15252/MSB.20145584

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25953765%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25953765%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

25953765

1 reference