(Q35737974)

English

Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways

scientific article published on 16 November 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

8

object named as

Pasi Janne

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Europe PubMed Central

PubMed publication ID

10 August 2017

author name string

Hiu-Fung Yuen

1

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Ka-Kui Chan

2

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Europe PubMed Central

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10 August 2017

Claire Grills

3

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Europe PubMed Central

PubMed publication ID

10 August 2017

James T Murray

4

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Angela Platt-Higgins

5

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Europe PubMed Central

PubMed publication ID

10 August 2017

Osama Sharaf Eldin

6

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Ken O'Byrne

7

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Dean A Fennell

9

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Patrick G Johnston

10

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Philip S Rudland

11

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Europe PubMed Central

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10 August 2017

Mohamed El-Tanani

12

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Europe PubMed Central

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10 August 2017

language of work or name

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publication date

16 November 2011

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Europe PubMed Central

PubMed publication ID

10 August 2017

Clinical Cancer Research

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Europe PubMed Central

PubMed publication ID

10 August 2017

18

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Europe PubMed Central

PubMed publication ID

10 August 2017

2

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Europe PubMed Central

PubMed publication ID

10 August 2017

380-391

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration

1 reference

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Interaction with Vascular Endothelium Enhances Survival in Primary Chronic Lymphocytic Leukemia Cells via NF-κB Activation andDe novoGene Transcription

1 reference

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PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer

1 reference

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Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation

1 reference

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Prostate cancer cells modulate osteoblast mineralisation and osteoclast differentiation through Id-1.

1 reference

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MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines

1 reference

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

1 reference

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Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis

1 reference

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RAN GTPase is an effector of the invasive/metastatic phenotype induced by osteopontin

1 reference

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Cotargeting survival signaling pathways in cancer

1 reference

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A gene signature-based approach identifies mTOR as a regulator of p73.

1 reference

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12 July 2018

Tumor cell dependence on Ran-GTP-directed mitosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

12 July 2018

Nucleocytoplasmic transport of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

12 July 2018

Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

12 July 2018

Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

12 July 2018

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

12 July 2018

Hyperactive Ras in developmental disorders and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

12 July 2018

PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR

1 reference

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12 July 2018

Identification of a tumour suppressor network opposing nuclear Akt function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

12 July 2018

Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

12 July 2018

Akt1 contains a functional leucine-rich nuclear export sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

12 July 2018

Targeting the mitogen-activated protein kinase cascade to treat cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

12 July 2018

Live Cell Imaging of ERK and MEK: simple binding equilibrium explains the regulated nucleocytoplasmic distribution of ERK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

12 July 2018

Ran, a small GTPase gene, encodes cytotoxic T lymphocyte (CTL) epitopes capable of inducing HLA-A33-restricted and tumor-reactive CTLs in cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

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Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

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Nuclear transport and cancer: from mechanism to intervention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

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ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

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Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.

1 reference

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Statistical significance for genomewide studies

1 reference

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Nuclear transport as a target for cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

1 reference

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Cancer. Addiction to oncogenes--the Achilles heal of cancer

1 reference

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The osteopontin-CD44 survival signal involves activation of the phosphatidylinositol 3-kinase/Akt signaling pathway

1 reference

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Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism

1 reference

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The Hallmarks of Cancer

1 reference

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Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

1 reference

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The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

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Dynamic localization of the nuclear import receptor and its interactions with transport factors

1 reference

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Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress.

1 reference

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Survivin, cancer networks and pathway-directed drug discovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

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TOR kinase and Ran are downstream from PI3K/Akt in H2O2-induced mitosis

1 reference

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Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272446

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Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer.

1 reference

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Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/22090358

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based on heuristic

inferred from PubMed ID database lookup

Signaling to nuclear transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/22090358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22090358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22090358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1078-0432.CCR-11-2035

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

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