(Q35745139)

10 August 2017

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title

Role of the CDK inhibitor p27 (Kip1) in mammary development and carcinogenesis: insights from knockout mice (English)

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10 August 2017

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Christopher J Ormandy

series ordinal

3

object named as

Christopher J Ormandy

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10 August 2017

Elizabeth A Musgrove

1

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PubMed ID

15082918

10 August 2017

Elizabeth A Davison

series ordinal

2

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10 August 2017

1 January 2004

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Journal of Mammary Gland Biology and Neoplasia

10 August 2017

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10 August 2017

9

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10 August 2017

55-66

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10 August 2017

1

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https://scigraph.springernature.com/pub.10.1023/b:jomg.0000023588.55733.84

10 August 2017

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cites work

Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis

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12 December 2020

Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice

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12 December 2020

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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12 December 2020

Suppression of Neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin E.

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12 December 2020

Regulation of the cdk inhibitor p27 and its deregulation in cancer

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12 December 2020

Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland.

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12 December 2020

Cancer susceptibility and the functions of BRCA1 and BRCA2

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12 December 2020

ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth

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12 December 2020

Inhibin and p27 interact to regulate gonadal tumorigenesis.

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12 December 2020

Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

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12 December 2020

p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis

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12 December 2020

Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer.

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12 December 2020

Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice

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12 December 2020

Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice

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12 December 2020

Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

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12 December 2020

Impaired mammary gland development in Cyl-1(-/-) mice during pregnancy and lactation is epithelial cell autonomous

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12 December 2020

Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice

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12 December 2020

New functional activities for the p21 family of CDK inhibitors

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12 December 2020

ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells

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12 December 2020

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

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12 December 2020

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

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12 December 2020

ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

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12 December 2020

BRCA1 expression status in relation to DNA methylation of the BRCA1 promoter region in sporadic breast cancers.

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12 December 2020

Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice

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12 December 2020

Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function

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12 December 2020

ErbB-2-induced mammary tumor growth: the role of cyclin D1 and p27Kip1.

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12 December 2020

Correlation of p27 protein expression with HER-2/neu expression in breast cancer.

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12 December 2020

The ErbB receptors and their role in cancer progression.

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12 December 2020

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

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12 December 2020

Functional microarray analysis of mammary organogenesis reveals a developmental role in adaptive thermogenesis.

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12 December 2020

p27 deregulation in breast cancer: prognostic significance and implications for therapy

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12 December 2020

Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

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12 December 2020

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

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12 December 2020

p27(Kip1) induces quiescence and growth factor insensitivity in tamoxifen-treated breast cancer cells

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12 December 2020

CDK inhibitors: positive and negative regulators of G1-phase progression

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12 December 2020

The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa->luteal transition

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12 December 2020

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

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12 December 2020

Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions

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12 December 2020

To cycle or not to cycle: a critical decision in cancer.

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12 December 2020

Mammary tumor formation in p53- and BRCA1-deficient mice

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12 December 2020

Untangling the ErbB signalling network

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12 December 2020

p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras Activation

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12 December 2020

Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

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12 December 2020

New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

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12 December 2020

Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis

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12 December 2020

Mechanisms of cyclin-dependent kinase inactivation by progestins

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12 December 2020

Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis

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12 December 2020

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

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12 December 2020

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

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12 December 2020

Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models

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12 December 2020

Specific protection against breast cancers by cyclin D1 ablation

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12 December 2020

Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity

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12 December 2020

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

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12 December 2020

Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and with benefit from one course of perioperative chemotherapy in patients with negative lymph node status: results

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12 December 2020

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

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12 December 2020

Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1

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12 December 2020

Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

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12 December 2020

BRCA-associated breast cancer: absence of a characteristic immunophenotype

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12 December 2020

The cyclin-dependent kinase inhibitor p27 (Kip1) regulates both DNA synthesis and apoptosis in mammary epithelium but is not required for its functional development during pregnancy

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12 December 2020

BRCA1 transactivates the cyclin-dependent kinase inhibitor p27(Kip1)

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12 December 2020

p27Kip1 and p21Cip1 Are Not Required for the Formation of Active D Cyclin-cdk4 Complexes

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12 December 2020

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

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12 December 2020

Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells

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12 December 2020

ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways

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12 December 2020

p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.

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12 December 2020

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

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12 December 2020

Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet.

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12 December 2020

Functional analysis of cyclin D2 and p27(Kip1) in cyclin D2 transgenic mouse mammary gland during development

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12 December 2020

ErbBs in mammary development

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12 December 2020

BRCA1-associated tumorigenesis: what have we learned from knockout mice?

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12 December 2020

p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.

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12 December 2020

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

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12 December 2020

High p27Kip1 Expression Predicts Superior Relapse-Free and Overall Survival for Premenopausal Women With Early-Stage Breast Cancer Receiving Adjuvant Treatment With Tamoxifen Plus Goserelin

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12 December 2020

10.1023/B:JOMG.0000023588.55733.84

Identifiers

DOI

1 reference

PubMed ID

15082918

Dimensions Publication ID

10 August 2017

0 references

1 reference

PubMed ID

15082918