(Q35745141)

10 August 2017

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title

p27 deregulation in breast cancer: prognostic significance and implications for therapy (English)

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10 August 2017

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Alkarain A

1

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10 August 2017

Jordan R

series ordinal

2

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10 August 2017

Slingerland J

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3

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10 August 2017

1 January 2004

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Journal of Mammary Gland Biology and Neoplasia

10 August 2017

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10 August 2017

9

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10 August 2017

67-80

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10 August 2017

1

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https://scigraph.springernature.com/pub.10.1023/b:jomg.0000023589.00994.5e

10 August 2017

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cites work

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas

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12 December 2020

Translational control of p27Kip1 accumulation during the cell cycle

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12 December 2020

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

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12 December 2020

Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.

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12 December 2020

The Clinical Significance of Epidermal Growth Factor Receptor (EGF-R) in Human Breast Cancer: A Review on 5232 Patients*

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12 December 2020

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein

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12 December 2020

Skp2 is oncogenic and overexpressed in human cancers

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12 December 2020

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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12 December 2020

c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer

1 reference

12 December 2020

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

1 reference

12 December 2020

p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors

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12 December 2020

Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.

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12 December 2020

Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer

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12 December 2020

Regulation of the cdk inhibitor p27 and its deregulation in cancer

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12 December 2020

Cyclin E dependent kinase activity in human breast cancer in relation to cyclin E, p27 and p21 expression and retinoblastoma protein phosphorylation

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12 December 2020

Growth signaling: TSC takes its place.

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12 December 2020

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

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12 December 2020

Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

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12 December 2020

Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents

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12 December 2020

Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer.

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12 December 2020

Immunohistochemical analysis of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: its correlation to histologic findings in 43 cases

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12 December 2020

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

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12 December 2020

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

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12 December 2020

Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

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12 December 2020

Regulation of the cell cycle machinery by oncogenic ras.

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12 December 2020

Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma

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12 December 2020

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

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12 December 2020

BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway

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12 December 2020

High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers

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12 December 2020

Prognostic impact of cyclin-dependent kinase inhibitor p27kip1 in node-positive breast cancer

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12 December 2020

Third annual William L. McGuire Memorial Lecture. "Studies on the estrogen receptor in breast cancer"--20 years as a target for the treatment and prevention of cancer

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12 December 2020

Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization

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12 December 2020

New functional activities for the p21 family of CDK inhibitors

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12 December 2020

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

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12 December 2020

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

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12 December 2020

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

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12 December 2020

Cell cycle proteins do not predict outcome in grade I infiltrating ductal carcinoma of the breast

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12 December 2020

Prognostic role of p27Kip1 and apoptosis in human breast cancer

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12 December 2020

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

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12 December 2020

Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action

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12 December 2020

Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas.

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12 December 2020

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

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12 December 2020

TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

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12 December 2020

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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12 December 2020

Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway.

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12 December 2020

p27 expression correlates with short-term, but not with long-term prognosis in breast cancer

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12 December 2020

Increased expression levels of cyclin-dependent kinase inhibitor p27 correlate with good responses to platinum-based chemotherapy in non-small cell lung cancer

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12 December 2020

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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12 December 2020

ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

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12 December 2020

Up-regulation of p27Kip1, p21WAF1/Cip1 and p16Ink4a is associated with, but not sufficient for, induction of squamous differentiation

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12 December 2020

ACTH promotion of p27(Kip1) induction in mouse Y1 adrenocortical tumor cells is dependent on both PKA activation and Akt/PKB inactivation.

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12 December 2020

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

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12 December 2020

Role of cell shape in growth control

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12 December 2020

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

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12 December 2020

Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor

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12 December 2020

A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells

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12 December 2020

Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells

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12 December 2020

Correlation of p27 protein expression with HER-2/neu expression in breast cancer.

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12 December 2020

Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells

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12 December 2020

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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12 December 2020

Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis

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12 December 2020

Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORF

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12 December 2020

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

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12 December 2020

G1 phase progression: cycling on cue

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12 December 2020

Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors

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12 December 2020

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

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12 December 2020

Cyclin E-CDK2 is a regulator of p27Kip1.

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12 December 2020

Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60.

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12 December 2020

Integration of signal transduction inhibitors with endocrine therapy: an approach to overcoming hormone resistance in breast cancer

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12 December 2020

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

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12 December 2020

CDK inhibitors: positive and negative regulators of G1-phase progression

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12 December 2020

High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas

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12 December 2020

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

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12 December 2020

Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells

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12 December 2020

Dependence of cyclin E-CDK2 kinase activity on cell anchorage.

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12 December 2020

p27kip1 expression in breast carcinomas: An immunohistochemical study on 512 patients with long-term follow-up

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12 December 2020

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

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12 December 2020

Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state

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12 December 2020

Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma

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12 December 2020

Prognostic factors in breast cancer: current and new predictors of metastasis

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12 December 2020

E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.

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12 December 2020

G1 control in mammalian cells.

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12 December 2020

Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27(Kip1)

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12 December 2020

Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2

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12 December 2020

Breast cancer banishes p27 from nucleus

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12 December 2020

A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.

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12 December 2020

Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions

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12 December 2020

p21WAF1 immunohistochemical expression in breast carcinoma: correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival

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12 December 2020

Inhibitors of mammalian G1 cyclin-dependent kinases

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12 December 2020

Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression

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12 December 2020

Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27

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12 December 2020

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

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12 December 2020

Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest

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12 December 2020

p27/kip1 expression in normal epithelium, benign and neoplastic breast lesions

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12 December 2020

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

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12 December 2020

Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer.

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12 December 2020

p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras Activation

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12 December 2020

Expression of p27 and p53 in cervical squamous cell carcinoma patients treated with radiotherapy alone: radiotherapeutic effect and prognosis

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12 December 2020

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

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12 December 2020

Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export

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12 December 2020

Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

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12 December 2020

Role of the F-box protein Skp2 in lymphomagenesis

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12 December 2020

Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization

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12 December 2020

Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma

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12 December 2020

Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes

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12 December 2020

Anchorage-dependent cell cycle progression

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12 December 2020

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

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12 December 2020

Prognostic implications of expression of the cell cycle inhibitor protein p27Kip1.

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12 December 2020

Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis

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12 December 2020

Prediction of recurrence for advanced breast cancer. Traditional and contemporary pathologic and molecular markers.

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12 December 2020

Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma

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12 December 2020

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

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12 December 2020

HER-2/neu as a predictive marker of response to breast cancer therapy

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12 December 2020

Elevated levels of p27, p21 and cyclin D1 correlate with positive oestrogen and progesterone receptor status in node-negative breast carcinoma patients

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12 December 2020

Cyclin-dependent kinase inhibitor p27Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma

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12 December 2020

Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts

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12 December 2020

The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts

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12 December 2020

PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

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12 December 2020

Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and with benefit from one course of perioperative chemotherapy in patients with negative lymph node status: results

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12 December 2020

Nuclear localization of beta-catenin by interaction with transcription factor LEF-1

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12 December 2020

The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas

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12 December 2020

Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest.

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12 December 2020

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

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12 December 2020

Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation.

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12 December 2020

Low p27 expression predicts poor disease-free survival in patients with prostate cancer

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12 December 2020

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

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12 December 2020

RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity

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12 December 2020

Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells.

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12 December 2020

ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.

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12 December 2020

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

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12 December 2020

Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation.

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12 December 2020

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

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12 December 2020

Functional interaction of beta-catenin with the transcription factor LEF-1

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12 December 2020

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

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12 December 2020

Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1.

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12 December 2020

The role of p27kip1 in the in vitro differentiation of murine keratinocytes

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12 December 2020

Prognostic value of the type I growth factor receptors in a large series of human primary breast cancers quantified with a real-time reverse transcription-polymerase chain reaction assay

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12 December 2020

A cell cycle-regulated inhibitor of cyclin-dependent kinases

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12 December 2020

Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation

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12 December 2020

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

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12 December 2020

Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells

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12 December 2020

Clinical trial design and end points for epidermal growth factor receptor-targeted therapies: implications for drug development and practice

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12 December 2020

ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways

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12 December 2020

Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies

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12 December 2020

Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells

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12 December 2020

Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.

1 reference

12 December 2020

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)

1 reference

12 December 2020

Tamoxifen in cancer therapy: minireview

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12 December 2020

A comparison of cell cycle markers in well-differentiated lobular and ductal carcinomas

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12 December 2020

Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias

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12 December 2020

10.1023/B:JOMG.0000023589.00994.5E

Identifiers

DOI

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Dimensions Publication ID

10 August 2017

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