(Q35763155)

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Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes.

scientific article published on 12 December 2011

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18 January 2020

Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes (English)

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18 January 2020

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Scott H Kaufmann

7

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18 January 2020

Jennifer S McDonald

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Jennifer S McDonald

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18 January 2020

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Anand G Patel

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18 January 2020

Karen S Flatten

2

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18 January 2020

Paula A Schneider

3

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18 January 2020

Nga T Dai

4

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18 January 2020

Guy G Poirier

6

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18 January 2020

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12 December 2011

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18 January 2020

Journal of Biological Chemistry

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18 January 2020

287

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18 January 2020

6

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18 January 2020

4198-4210

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18 January 2020

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Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells.

1 reference

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Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

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Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies

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Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

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Overcoming S-phase checkpoint-mediated resistance: sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines

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PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites

1 reference

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ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models

1 reference

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Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.

1 reference

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Topoisomerase I inhibitors: camptothecins and beyond

1 reference

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Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy

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SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

1 reference

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Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

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The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons

1 reference

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PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli

1 reference

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Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.

1 reference

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Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein

1 reference

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RNA interference directed against Poly(ADP-Ribose) polymerase 1 efficiently suppresses human immunodeficiency virus type 1 replication in human cells

1 reference

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Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

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Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme

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S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function

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DNA topoisomerase poisons as antitumor drugs

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12 July 2018

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25 September 2018

The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks.

1 reference

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25 September 2018

Poly(ADP-ribose) polymerase-1 could facilitate the religation of topoisomerase I-linked DNA inhibited by camptothecin

1 reference

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25 September 2018

Poly(ADP-ribosyl)ation as a DNA damage-induced post-translational modification regulating poly(ADP-ribose) polymerase-1-topoisomerase I interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281688

25 September 2018

Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281688

25 September 2018

Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281688

25 September 2018

Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281688

25 September 2018

Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281688

25 September 2018

X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281688

25 September 2018

Molecular interactions between poly(ADP-ribose) polymerase (PARP I) and topoisomerase I (Topo I): identification of topology of binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281688

25 September 2018

Random mutagenesis of the poly(ADP-ribose) polymerase catalytic domain reveals amino acids involved in polymer branching.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281688

25 September 2018

Reutilization of Immunoblots after Chemiluminescent Detection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.296475

21 January 2018

Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281688

23 October 2018

Altered formation of topotecan-stabilized topoisomerase I-DNA adducts in human leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281688

23 October 2018

Additional members of the rat liver lamin polypeptide family. Structural and immunological characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281688

23 October 2018

Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: evidence for increased tumor cell apoptosis in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22158865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of topoisomerase I by poly [ADP-ribose] polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22158865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human bone marrow colony growth in agar-gel

1 reference

https://pubmed.ncbi.nlm.nih.gov/22158865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of eukaryotic topoisomerase I reactivity with DNA. Preferential cleavage of supercoiled DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/22158865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/22158865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/22158865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22158865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoelectron microscopical distribution of poly(ADP-ribose)polymerase in the mammalian cell nucleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22158865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22158865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Embryonic stem cells deficient for Brca2 or Blm exhibit divergent genotoxic profiles that support opposing activities during homologous recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/22158865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.296475

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158865%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158865%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158865%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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