(Q35830402)

10 August 2017

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title

The bounty of RAGs: recombination signal complexes and reaction outcomes (English)

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10 August 2017

Patrick C Swanson

1

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10 August 2017

publication date

1 August 2004

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10 August 2017

published in

Immunological Reviews

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10 August 2017

volume

200

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10 August 2017

page(s)

90-114

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The mechanism and regulation of chromosomal V(D)J recombination

10 August 2017

cites work

1 reference

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

21 January 2018

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V(D)J recombination: RAG proteins, repair factors, and regulation

21 January 2018

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The RAG proteins in V(D)J recombination: more than just a nuclease

21 January 2018

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Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

21 January 2018

1 reference

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The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire

21 January 2018

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Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage

21 January 2018

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The V(D)J recombination activating gene, RAG-1.

21 January 2018

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The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

21 January 2018

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HMG1 and 2, and related 'architectural' DNA-binding proteins

21 January 2018

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Revised nomenclature for high mobility group (HMG) chromosomal proteins

21 January 2018

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Stimulation of V(D)J cleavage by high mobility group proteins

21 January 2018

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V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins

21 January 2018

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

21 January 2018

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Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

21 January 2018

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Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

21 January 2018

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Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination?

21 January 2018

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Mechanism and regulation of human non-homologous DNA end-joining

21 January 2018

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Evolution of antigen binding receptors

21 January 2018

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A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals

21 January 2018

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RAG-1 and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution

21 January 2018

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V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.

21 January 2018

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RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Self-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

GST-Induced dimerization of DNA-binding domains alters characteristics of their interaction with DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Partial V(D)J recombination activity leads to Omenn syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

The C-terminal portion of RAG2 protects against transposition in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Initiation of V(D)J recombination in vitro obeying the 12/23 rule

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

RAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Definition of minimal domains of interaction within the recombination-activating genes 1 and 2 recombinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

The effect of Me2+ cofactors at the initial stages of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Footprint analysis of recombination signal sequences in the 12/23 synaptic complex of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Identification of basic residues in RAG2 critical for DNA binding by the RAG1-RAG2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

RAG1-DNA binding in V(D)J recombination. Specificity and DNA-induced conformational changes revealed by fluorescence and CD spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Functional organization of single and paired V(D)J cleavage complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Assembly of the RAG1/RAG2 synaptic complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Ordered assembly of the V(D)J synaptic complex ensures accurate recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Mechanism for specificity by HMG-1 in enhanceosome assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

The DNA architectural protein HMGB1 displays two distinct modes of action that promote enhanceosome assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

RAG2 is down-regulated by cytoplasmic sequestration and ubiquitin-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Tn5 as a model for understanding DNA transposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Determinants for hairpin formation in Tn10 transposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Integrating DNA: transposases and retroviral integrases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Trans catalysis in Tn5 transposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Three-dimensional structure of the Tn5 synaptic complex transposition intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Factors that influence formation of B cell repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Sequence of the spacer in the recombination signal sequence affects V(D)J rearrangement frequency and correlates with nonrandom Vkappa usage in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Why PLoS became a publisher

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

V(D)J Recombination Frequencies Can Be Profoundly Affected by Changes in the Spacer Sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Rejoining of DNA by the RAG1 and RAG2 proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

In vivo transposition mediated by V(D)J recombinase in human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Inverse transposition by the RAG1 and RAG2 proteins: role reversal of donor and target DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

DNA hairpin opening mediated by the RAG1 and RAG2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

RAG transposase can capture and commit to target DNA before or after donor cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Postcleavage sequence specificity in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

The RAG1 N-terminal domain is an E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

Cell-free V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00159.X

10.1111/J.0105-2896.2004.00159.X

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference