(Q35998774)

11 August 2017

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title

Drosophila, the golden bug, emerges as a tool for human genetics (English)

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11 August 2017

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Ethan Bier

1

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11 August 2017

publication date

1 January 2005

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11 August 2017

published in

Nature Reviews Genetics

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11 August 2017

volume

6

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11 August 2017

issue

1

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11 August 2017

page(s)

9-23

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https://scigraph.springernature.com/pub.10.1038/nrg1503

11 August 2017

exact match

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cites work

A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster

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Homophila: human disease gene cognates in Drosophila

21 January 2018

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The genome sequence of Drosophila melanogaster

21 January 2018

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A survey of human disease gene counterparts in the Drosophila genome

21 January 2018

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Molecular and comparative genetics of mental retardation

21 January 2018

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Dorsal-ventral signaling in limb development

21 January 2018

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Fringe: defining borders by regulating the notch pathway

21 January 2018

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The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries

21 January 2018

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lunatic fringe is an essential mediator of somite segmentation and patterning

21 January 2018

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Defects in somite formation in lunatic fringe-deficient mice

21 January 2018

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Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

21 January 2018

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Mutations in the human Jagged1 gene are responsible for Alagille syndrome

21 January 2018

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Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis

21 January 2018

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Human neurodegenerative disease modeling using Drosophila.

21 January 2018

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Dying for a cause: invertebrate genetics takes on human neurodegeneration

21 January 2018

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Modelling neurodegenerative diseases in Drosophila: a fruitful approach?

21 January 2018

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From fruit fly to bedside: translating lessons from Drosophila models of neurodegenerative disease

21 January 2018

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Lessons from animal models of Huntington's disease

21 January 2018

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Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases

21 January 2018

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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

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Genetic suppression of polyglutamine toxicity in Drosophila

21 January 2018

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Identification of genes that modify ataxin-1-induced neurodegeneration.

21 January 2018

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

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Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

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Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

21 January 2018

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The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila.

21 January 2018

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Pharmacological prevention of Parkinson disease in Drosophila.

21 January 2018

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Alpha-synuclein in Lewy bodies

21 January 2018

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A Drosophila model of Parkinson's disease

21 January 2018

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

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Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

21 January 2018

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Parkin counteracts symptoms in a Drosophila model of Parkinson's disease

21 January 2018

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Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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A common enzyme connects notch signaling and Alzheimer's disease

21 January 2018

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

21 January 2018

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

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A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

21 January 2018

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

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The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

21 January 2018

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The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

21 January 2018

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

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Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

21 January 2018

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Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

21 January 2018

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Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

21 January 2018

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

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Drosophila nicastrin is essential for the intramembranous cleavage of notch

21 January 2018

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Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

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Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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RNA interference: a new mechanism by which FMRP acts in the normal brain? What can Drosophila teach us?

21 January 2018

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Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function

21 January 2018

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Control of dendritic development by theDrosophila fragile X-relatedgene involves the small GTPase Rac1

21 January 2018

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A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

21 January 2018

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Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway

21 January 2018

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RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila

21 January 2018

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Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

21 January 2018

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let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

21 January 2018

1 reference

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

21 January 2018

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The gene lin-3 encodes an inductive signal for vulval development in C. elegans

21 January 2018

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C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.

21 January 2018

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The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development

21 January 2018

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Tuberous sclerosis complex: from Drosophila to human disease.

21 January 2018

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TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

21 January 2018

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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

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The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

21 January 2018

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Body building: regulation of shape and size by PI3K/TOR signaling during development

21 January 2018

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Why size matters: altering cell size

21 January 2018

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Tumour suppressors--a fly's perspective

21 January 2018

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salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

21 January 2018

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

21 January 2018

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Genes that drive invasion and migration in Drosophila

21 January 2018

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A Genetic Screen in Drosophila for Metastatic Behavior

21 January 2018

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scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila

21 January 2018

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The spectrum of mutations in UBE3A causing Angelman syndrome

21 January 2018

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UBE3A/E6-AP mutations cause Angelman syndrome

21 January 2018

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De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome

21 January 2018

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Removal of hydrogen peroxide by thiol-specific antioxidant enzyme (TSA) is involved with its antioxidant properties. TSA possesses thiol peroxidase activity.

21 January 2018

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Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG

21 January 2018

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Mutations in CYP1B1, the gene for cytochrome P4501B1, are the predominant cause of primary congenital glaucoma in Saudi Arabia

21 January 2018

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Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21

21 January 2018

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The International HapMap Project

21 January 2018

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Congenital disorders of glycosylation: genetic model systems lead the way.

21 January 2018

1 reference

A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic

21 January 2018

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Deficiency of the first mannosylation step in the N-glycosylation pathway causes congenital disorder of glycosylation type Ik.

21 January 2018

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A frequent mild mutation in ALG6 may exacerbate the clinical severity of patients with congenital disorder of glycosylation Ia (CDG-Ia) caused by phosphomannomutase deficiency

21 January 2018

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Heart development in Drosophila and its relationship to vertebrates.

21 January 2018

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Multiplex detection of RNA expression in Drosophila embryos

21 January 2018

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Tissue-specific expression of dominant negative mutant Drosophila HSC70 causes developmental defects and lethality

21 January 2018

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Defective glia in the Drosophila brain degeneration mutant drop-dead

21 January 2018

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Drosophila drop-dead mutations accelerate the time course of age-related markers

21 January 2018

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Extended life-span and stress resistance in the Drosophila mutant methuselah

21 January 2018

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A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

21 January 2018

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The endocrine regulation of aging by insulin-like signals

21 January 2018

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

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Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta

21 January 2018

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Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

21 January 2018

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The making of the somite: molecular events in vertebrate segmentation

21 January 2018

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Segmentation in vertebrates: clock and gradient finally joined

21 January 2018

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Oscillations, clocks and segmentation

21 January 2018

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Modulation of signalling by Sprouty: a developing story

21 January 2018

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Genomic structure of HOXD13 gene: a nine polyalanine duplication causes synpolydactyly in two unrelated families

21 January 2018

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Synpolydactyly phenotypes correlate with size of expansions in HOXD13 polyalanine tract

21 January 2018

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Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster

21 January 2018

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Deletions in HOXD13 segregate with an identical, novel foot malformation in two unrelated families

21 January 2018

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Novel HOXA13 mutations and the phenotypic spectrum of hand-foot-genital syndrome

21 January 2018

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Mutation of HOXA13 in hand-foot-genital syndrome

21 January 2018

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The molecular basis of hypodactyly (Hd): a deletion in Hoxa 13 leads to arrest of digital arch formation

21 January 2018

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Haploinsufficiency of the HOXA gene cluster, in a patient with hand-foot-genital syndrome, velopharyngeal insufficiency, and persistent patent Ductus botalli

21 January 2018

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twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development

21 January 2018

1 reference

SALL1 mutations in Townes-Brocks syndrome and related disorders

21 January 2018

1 reference

Study of the specific heat of a CeCoAl4 single crystal in high magnetic fields

21 January 2018

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GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

21 January 2018

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Gata factor Pannier is required to establish competence for heart progenitor formation

21 January 2018

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The GATA family (vertebrates and invertebrates).

21 January 2018

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Drosophila Tbx6-related gene, Dorsocross, mediates high levels of Dpp and Scw signal required for the development of amnioserosa and wing disc primordium

21 January 2018

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The T-box-encoding Dorsocross genes function in amnioserosa development and the patterning of the dorsolateral germ band downstream of Dpp.

21 January 2018

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Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2

21 January 2018

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Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

21 January 2018

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Fly models of Huntington's disease

21 January 2018

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Experimental therapeutics in Huntington's disease: are models useful for therapeutic trials?

21 January 2018

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Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

21 January 2018

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Tau neurotoxicity without the lesions: a fly challenges a tangled web.

21 January 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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Understanding fragile X syndrome: insights from animal models

21 January 2018

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Human disorders of ubiquitination and proteasomal degradation

21 January 2018

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Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38

21 January 2018

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Tuberous sclerosis complex: genetics to pathogenesis

21 January 2018

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Modeling transformation and metastasis in Drosophila

21 January 2018

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Mutations of the TWIST gene in the Saethre-Chotzen syndrome

21 January 2018

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The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos

21 January 2018

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Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo

31 March 2020

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twist and snail as positive and negative regulators during Drosophila mesoderm development.

31 March 2020

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Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation

31 March 2020

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Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages

31 March 2020

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heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo

31 March 2020

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Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity

31 March 2020

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dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo

31 March 2020

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Altered protein acetylation in polyglutamine diseases.

31 March 2020

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Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

31 March 2020

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A familial Alzheimer's disease locus on chromosome 1.

31 March 2020

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A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

31 March 2020

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Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.

31 March 2020

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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

31 March 2020

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Removals of hydrogen peroxide and hydroxyl radical by thiol-specific antioxidant protein as a possible role in vivo

31 March 2020

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Deficiency of dolichol-phosphate-mannose synthase-1 causes congenital disorder of glycosylation type Ie

31 March 2020

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Screening assays for heart function mutants in Drosophila.

31 March 2020

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Insulin regulation of heart function in aging fruit flies

31 March 2020

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Paralysis and early death in cysteine string protein mutants of Drosophila

31 March 2020

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The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila.

31 March 2020

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Unearthing Loci that influence life span

31 March 2020

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Inside insulin signaling, communication is key to long life

31 March 2020

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There's a problem in the furnace

31 March 2020

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Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13

31 March 2020

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Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans

31 March 2020

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Congenital heart disease caused by mutations in the transcription factor NKX2-5

31 March 2020

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Understanding the biological underpinnings of fragile X syndrome

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1503

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11 August 2017

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