(Q35586717)

9 August 2017

1 reference

title

Body building: regulation of shape and size by PI3K/TOR signaling during development (English)

1 reference

9 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14623438

developmental gene expression regulation

3 April 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14623438

3 April 2024

autophagy

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14623438

3 April 2024

1

Thomas P. Neufeld

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14623438

3 April 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14623438

3 April 2024

publication date

1 November 2003

1 reference

full work available at URL

9 August 2017

https://doi.org/10.1016/j.mod.2003.07.003

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14623438

https://api.elsevier.com/content/article/PII:S0925477303002041?httpAccept=text/xml

3 April 2024

1 reference

https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

https://api.elsevier.com/content/article/PII:S0925477303002041?httpAccept=text/plain

3 April 2024

1 reference

https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Mechanisms of Development

3 April 2024

published in

1 reference

9 August 2017

volume

120

1 reference

9 August 2017

issue

11

1 reference

9 August 2017

page(s)

1283-1296

1 reference

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

9 August 2017

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1 reference

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Identification and characterization of two distinct intracellular GLUT4 pools in rat skeletal muscle: evidence for an endosomal and an insulin-sensitive GLUT4 compartment

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Forkhead transcription factors contribute to execution of the mitotic programme in mammals

3 April 2024

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The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway

3 April 2024

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An Essay on leaf shape

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S6 phosphorylation-independent pathways regulate translation of 5'-terminal oligopyrimidine tract-containing mRNAs in differentiating hematopoietic cells

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Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast

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Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity

3 April 2024

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Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

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The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes

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Autophagic proteolysis: control and specificity

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Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrations

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Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

3 April 2024

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Growth regulation in Hydra: relationship between epithelial cell cycle length and growth rate

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Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions.

3 April 2024

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

3 April 2024

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

3 April 2024

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Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

3 April 2024

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Regulated transport of the glucose transporter GLUT4

3 April 2024

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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Patterning mechanisms controlling vertebrate limb development

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The TOR signaling cascade regulates gene expression in response to nutrients

3 April 2024

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Regulation of cell death protease caspase-9 by phosphorylation

3 April 2024

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Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

3 April 2024

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Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.

3 April 2024

27

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Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

3 April 2024

28

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Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner

3 April 2024

29

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Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner.

3 April 2024

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Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

3 April 2024

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Faster synthesis and slower degradation of liver protein during developmental growth

3 April 2024

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Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression

3 April 2024

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Extracellular control of cell size

3 April 2024

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Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae.

3 April 2024

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

3 April 2024

36

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The Drosophila cyclin D-Cdk4 complex promotes cellular growth

3 April 2024

38

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

3 April 2024

39

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Studies on insulin-like growth factor-I and insulin in chick limb morphogenesis

3 April 2024

40

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Mammalian TOR: a homeostatic ATP sensor

3 April 2024

41

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Studies on the mechanisms of autophagy: formation of the autophagic vacuole

3 April 2024

42

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Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

3 April 2024

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The development and evolution of exaggerated morphologies in insects

3 April 2024

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Inhibition of autophagy in mitotic animal cells

3 April 2024

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TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

3 April 2024

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Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

3 April 2024

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Mechanisms of spindle positioning: focus on flies and worms

3 April 2024

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A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.

3 April 2024

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Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression

3 April 2024

52

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Interaction of synthetic polynucleotides with small rat liver ribosomal subunits possessing low and highly phosphorylated protein S6

3 April 2024

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Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells

3 April 2024

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Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

3 April 2024

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

3 April 2024

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Normal activation of p70 S6 kinase by insulin in cells overexpressing dominant negative 85kD subunit of phosphoinositide 3-kinase

3 April 2024

58

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

3 April 2024

59

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

3 April 2024

60

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

3 April 2024

61

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

3 April 2024

62

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Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

3 April 2024

63

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Dominant negative mutants of the Cdc2 kinase uncouple cell division from iterative plant development.

3 April 2024

64

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Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila

3 April 2024

65

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Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein

3 April 2024

66

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Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)

3 April 2024

67

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Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes

3 April 2024

68

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Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells

3 April 2024

69

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Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation

3 April 2024

70

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

3 April 2024

71

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Tor signalling in bugs, brain and brawn

3 April 2024

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Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

3 April 2024

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Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

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Drosophila myc regulates cellular growth during development.

3 April 2024

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Tor-mediated induction of autophagy via an Apg1 protein kinase complex

3 April 2024

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Shaping the vertebrate body plan by polarized embryonic cell movements

3 April 2024

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

3 April 2024

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Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells.

3 April 2024

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The shaping of pharyngeal cartilages during early development of the zebrafish.

3 April 2024

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Formation process of autophagosome is traced with Apg8/Aut7p in yeast

3 April 2024

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Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation

3 April 2024

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Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors

3 April 2024

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Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.

3 April 2024

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Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors

3 April 2024

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Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin

3 April 2024

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Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.

3 April 2024

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Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

3 April 2024

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Essential role of PDK1 in regulating cell size and development in mice

3 April 2024

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The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts

3 April 2024

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Role of PI3-kinase in Bcl-X induction and apoptosis inhibition mediated by IL-3 or IGF-1 in Baf-3 cells

3 April 2024

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Induction of autophagy and inhibition of tumorigenesis by beclin 1

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

3 April 2024

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Rapamycin resistance tied to defective regulation of p27Kip1.

3 April 2024

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Modulation of transcription of rRNA genes by rapamycin

3 April 2024

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Regulation of System A amino acid transport in L6 rat skeletal muscle cells by insulin, chemical and hyperthermic stress

3 April 2024

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TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

3 April 2024

97

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

3 April 2024

98

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Cell cycling and patterned cell proliferation in the Drosophila wing during metamorphosis

3 April 2024

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Cell cycling and patterned cell proliferation in the wing primordium of Drosophila.

3 April 2024

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The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

3 April 2024

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Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?

3 April 2024

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Drosophila S6 kinase: a regulator of cell size

3 April 2024

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Minutes: Mutants of Drosophila autonomously affecting cell division rate

3 April 2024

105

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Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway

3 April 2024

106

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Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

3 April 2024

107

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Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

3 April 2024

109

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The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes

3 April 2024

110

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Amino Acids Regulate Hepatocyte Proliferation through Modulation of Cyclin D1 Expression

3 April 2024

111

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Coordination of growth and cell division in the Drosophila wing

3 April 2024

113

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Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

3 April 2024

114

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Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

3 April 2024

116

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Differences in the rates of protein degradation in untransformed and transformed cell lines

3 April 2024

117

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Protein turnover and cellular autophagy in growing and growth-inhibited 3T3 cells

3 April 2024

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A Restriction Point for Control of Normal Animal Cell Proliferation

3 April 2024

119

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The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

3 April 2024

120

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Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

3 April 2024

121

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Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy

3 April 2024

122

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A morphometric study of the inhibition of autophagic degradation during restorative growth of liver cells in rats re-fed after starvation

3 April 2024

124

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast

3 April 2024

125

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

3 April 2024

126

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Akt regulates growth by directly phosphorylating Tsc2

3 April 2024

127

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Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae

3 April 2024

128

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Ras1 promotes cellular growth in the Drosophila wing

3 April 2024

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Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing

3 April 2024

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Regulation of mammalian translation factors by nutrients

3 April 2024

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Interplay between insulin and nutrients in the regulation of translation factors

3 April 2024

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dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

3 April 2024

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Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

3 April 2024

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Determining the role of patterned cell proliferation in the shape and size of the Drosophila wing

3 April 2024

135

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PDK1 regulates growth through Akt and S6K in Drosophila

3 April 2024

136

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

The role of C/EBP in nutrient and hormonal regulation of gene expression

3 April 2024

137

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation

3 April 2024

138

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Growth dynamics underlying petal shape and asymmetry

3 April 2024

139

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

3 April 2024

140

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Differential tissue growth and patterns of cell death in mouse limb autopod morphogenesis

3 April 2024

141

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Rheb promotes cell growth as a component of the insulin/TOR signalling network

3 April 2024

142

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease

3 April 2024

143

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

3 April 2024

144

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

3 April 2024

145

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

3 April 2024

146

1 reference

https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

3 April 2024

147

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

3 April 2024

148

1 reference

https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins

3 April 2024

149

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

3 April 2024

150

1 reference

https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

3 April 2024

151

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Akt/protein kinase B promotes organ growth in transgenic mice

3 April 2024

152

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Parameters of cell competition in the compartments of the wing disc of Drosophila

3 April 2024

153

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

The tangled-1 mutation alters cell division orientations throughout maize leaf development without altering leaf shape

3 April 2024

154

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A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation

3 April 2024

155

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

The mRNA 5' cap-binding protein eIF4E and control of cell growth

3 April 2024

156

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The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

3 April 2024

157

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Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

3 April 2024

158

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Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

3 April 2024

159

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Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

3 April 2024

160

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

3 April 2024

161

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Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

3 April 2024

162

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

3 April 2024

163

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Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

3 April 2024

164

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An encore for ribosome biogenesis in the control of cell proliferation

3 April 2024

165

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Cellular signaling: pivoting around PDK-1.

3 April 2024

166

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Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

3 April 2024

168

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Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

3 April 2024

169

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Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

3 April 2024

170

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Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor

3 April 2024

172

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Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

3 April 2024

173

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Multiple independent inputs are required for activation of the p70 S6 kinase

3 April 2024

174

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Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

3 April 2024

175

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https://api.crossref.org/works/10.1016/J.MOD.2003.07.003

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

3 April 2024

176

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

3 April 2024

177

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3 April 2024

Identifiers

1 reference

9 August 2017

1 reference