(Q35998861)

11 August 2017

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title

The telomerase cycle: normal and pathological aspects (English)

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11 August 2017

Michele Brunori

1

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11 August 2017

Pierre Luciano

series ordinal

2

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11 August 2017

Eric Gilson

series ordinal

3

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11 August 2017

Vincent Géli

series ordinal

4

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11 August 2017

4 January 2005

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Journal of Molecular Medicine

11 August 2017

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11 August 2017

83

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11 August 2017

244-257

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11 August 2017

4

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https://scigraph.springernature.com/pub.10.1007/s00109-004-0616-2

11 August 2017

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cites work

The yeast telomere length counting machinery is sensitive to sequences at the telomere-nontelomere junction.

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Crossref

https://api.crossref.org/works/10.1007%2FS00109-004-0616-2

Gene expression for suppressors of telomerase activity (telomeric-repeat binding factors) in breast cancer

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FS00109-004-0616-2

The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities

21 January 2018

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12 December 2020

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

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12 December 2020

Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo.

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12 December 2020

Tethering on the brink: the evolutionarily conserved Mre11-Rad50 complex

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12 December 2020

The paradoxical relationship between NHEJ and telomeric fusion

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12 December 2020

RPA regulates telomerase action by providing Est1p access to chromosome ends

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12 December 2020

Clues to catastrophic telomere loss in mammals from yeast telomere rapid deletion

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12 December 2020

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

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12 December 2020

Human POT1 facilitates telomere elongation by telomerase

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12 December 2020

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

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12 December 2020

Yeast telomerase appears to frequently copy the entire template in vivo.

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12 December 2020

TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

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12 December 2020

TIN2, a new regulator of telomere length in human cells

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12 December 2020

PTOP interacts with POT1 and regulates its localization to telomeres

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12 December 2020

The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation

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12 December 2020

Functional interaction between Ku and the werner syndrome protein in DNA end processing

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12 December 2020

The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.

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12 December 2020

The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance

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12 December 2020

Reverse transcriptase motifs in the catalytic subunit of telomerase

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12 December 2020

The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast

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12 December 2020

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae

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12 December 2020

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

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12 December 2020

Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas

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12 December 2020

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

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12 December 2020

Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance

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12 December 2020

Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends

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12 December 2020

Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment

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12 December 2020

spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast.

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12 December 2020

Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint

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12 December 2020

The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo

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12 December 2020

The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex

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12 December 2020

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

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12 December 2020

Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13

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12 December 2020

Yeast Ku as a regulator of chromosomal DNA end structure

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12 December 2020

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12 December 2020

Telomere-binding and Stn1p-interacting activities are required for the essential function of Saccharomyces cerevisiae Cdc13p

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12 December 2020

Telomere dysfunction alters the chemotherapeutic profile of transformed cells

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12 December 2020

Ku complex interacts with and stimulates the Werner protein

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12 December 2020

The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeres

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12 December 2020

Homologous DNA pairing by human recombination factors Rad51 and Rad54

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12 December 2020

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

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12 December 2020

Erosion of the telomeric single-strand overhang at replicative senescence

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12 December 2020

Control of telomere length by the human telomeric protein TRF1

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12 December 2020

TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.

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12 December 2020

Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1

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12 December 2020

A bulged stem tethers Est1p to telomerase RNA in budding yeast

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12 December 2020

Est1 and Cdc13 as comediators of telomerase access

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12 December 2020

Expression of mRNAs for telomeric repeat binding factor (TRF)-1 and TRF2 in atypical adenomatous hyperplasia and adenocarcinoma of the lung.

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12 December 2020

DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2

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12 December 2020

Ku acts in a unique way at the mammalian telomere to prevent end joining

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12 December 2020

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres

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12 December 2020

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

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12 December 2020

Multiple tumor suppressor pathways negatively regulate telomerase

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12 December 2020

Telomerase maintains telomere structure in normal human cells.

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12 December 2020

Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development

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12 December 2020

The Est3 protein is a subunit of yeast telomerase

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12 December 2020

Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining

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12 December 2020

Telomeres and their control

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12 December 2020

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

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12 December 2020

Sudden telomere lengthening triggers a Rad53-dependent checkpoint in Saccharomyces cerevisiae

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12 December 2020

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

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12 December 2020

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

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12 December 2020

Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.

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12 December 2020

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

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12 December 2020

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

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12 December 2020

Getting to the end: telomerase access in yeast and humans

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12 December 2020

TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex

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12 December 2020

Chromosomal instability in ulcerative colitis is related to telomere shortening

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12 December 2020

Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase

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12 December 2020

DNA ends: maintenance of chromosome termini versus repair of double strand breaks

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12 December 2020

Cell cycle localization, dimerization, and binding domain architecture of the telomere protein cPot1.

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12 December 2020

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

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12 December 2020

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

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12 December 2020

Telomeric localization of TRF2, a novel human telobox protein

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12 December 2020

Est1p as a cell cycle-regulated activator of telomere-bound telomerase

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12 December 2020

Fission yeast Rap1 homolog is a telomere-specific silencing factor and interacts with Taz1p.

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12 December 2020

Targeted deletion reveals an essential function for the telomere length regulator Trf1.

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12 December 2020

Telomerase modulates expression of growth-controlling genes and enhances cell proliferation

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12 December 2020

Telomerase activity in human renal cell carcinoma.

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12 December 2020

The function of DNA polymerase alpha at telomeric G tails is important for telomere homeostasis

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12 December 2020

Importance of TRF1 for Functional Telomere Structure

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12 December 2020

TLC1: template RNA component of Saccharomyces cerevisiae telomerase

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12 December 2020

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

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12 December 2020

The Saccharomyces cerevisiae mre11(ts) allele confers a separation of DNA repair and telomere maintenance functions

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12 December 2020

Telomerase: what are the Est proteins doing?

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12 December 2020

DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites

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12 December 2020

Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.

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12 December 2020

A DNA damage checkpoint response in telomere-initiated senescence

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12 December 2020

DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA

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12 December 2020

Cdc13 both positively and negatively regulates telomere replication

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12 December 2020

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

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12 December 2020

Creation of human tumour cells with defined genetic elements

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12 December 2020

Identification of human Rap1: implications for telomere evolution

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12 December 2020

Immortalization and transformation of primary human airway epithelial cells by gene transfer.

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12 December 2020

Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere

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12 December 2020

Chromosome instability in cancer: how, when, and why?

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12 December 2020

Pot1, the putative telomere end-binding protein in fission yeast and humans

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12 December 2020

Progressive cis-inhibition of telomerase upon telomere elongation.

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12 December 2020

RAP1: a protean regulator in yeast.

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12 December 2020

A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2

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12 December 2020

Impaired telomere regulation mechanism by TRF1 (telomere-binding protein), but not TRF2 expression, in acute leukemia cells

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12 December 2020

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance

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12 December 2020

The MRN complex: coordinating and mediating the response to broken chromosomes

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12 December 2020

Altering telomere structure allows telomerase to act in yeast lacking ATM kinases

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12 December 2020

Correlation between telomerase activity and telomeric-repeat binding factors in gastric cancer

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12 December 2020

Processing of telomeric DNA ends requires the passage of a replication fork

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12 December 2020

Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma.

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12 December 2020

Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

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12 December 2020

The terminal DNA structure of mammalian chromosomes

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12 December 2020

Rap1 affects the length and heterogeneity of human telomeres

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12 December 2020

Different telomere damage signaling pathways in human and mouse cells

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12 December 2020

Tankyrase promotes telomere elongation in human cells

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12 December 2020

A survey of telomerase activity in human cancer

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12 December 2020

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.

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12 December 2020

Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.

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12 December 2020

A critical role for telomeres in suppressing and facilitating carcinogenesis

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12 December 2020

Telomerase beyond telomeres

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12 December 2020

Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1

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12 December 2020

Pif1p helicase, a catalytic inhibitor of telomerase in yeast

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12 December 2020

The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro

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12 December 2020

Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication

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12 December 2020

Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?

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12 December 2020

Telomere maintenance is dependent on activities required for end repair of double-strand breaks.

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12 December 2020

Transformation of normal human cells in the absence of telomerase activation.

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12 December 2020

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

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12 December 2020

TRF2 Protects Human Telomeres from End-to-End Fusions

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12 December 2020

Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae

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12 December 2020

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

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12 December 2020

Telomere formation by rap1p binding site arrays reveals end-specific length regulation requirements and active telomeric recombination

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12 December 2020

Cdc13 subcomplexes regulate multiple telomere functions

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12 December 2020

Telomerase in human development and cancer

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12 December 2020

Cdc13 delivers separate complexes to the telomere for end protection and replication

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12 December 2020

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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12 December 2020

Composition and conservation of the telomeric complex

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12 December 2020

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12 December 2020

Inactivation of hTERT transcription by Tax.

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12 December 2020

Involvement of replicative polymerases, Tel1p, Mec1p, Cdc13p, and the Ku complex in telomere-telomere recombination.

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12 December 2020

DNA damage foci at dysfunctional telomeres

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12 December 2020

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

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12 December 2020

POT1 as a terminal transducer of TRF1 telomere length control

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12 December 2020

The telomerase reverse transcriptase: components and regulation

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12 December 2020

Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

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12 December 2020

Immunohistochemical TRF1 expression in human primary intracranial tumors

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12 December 2020

Identification of telomere-dependent "senescence-like" arrest in mouse embryonic fibroblasts

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12 December 2020

A protein-counting mechanism for telomere length regulation in yeast.

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12 December 2020

Differential processing of leading- and lagging-strand ends at Saccharomyces cerevisiae telomeres revealed by the absence of Rad27p nuclease

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12 December 2020

Switching and signaling at the telomere

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12 December 2020

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells.

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12 December 2020

Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation

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12 December 2020

The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor

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12 December 2020

Regulation of telomere length and function by a Myb-domain protein in fission yeast

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12 December 2020

The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanisms

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12 December 2020

Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2

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12 December 2020

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

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12 December 2020

An in vitro assay for Saccharomyces telomerase requires EST1.

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12 December 2020

Cell cycle restriction of telomere elongation

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12 December 2020

Inhibition of telomerase limits the growth of human cancer cells.

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12 December 2020

Protecting the terminus: t-loops and telomere end-binding proteins

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12 December 2020

Control of human telomere length by TRF1 and TRF2

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12 December 2020

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

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12 December 2020

CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis

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12 December 2020

The human Rap1 protein complex and modulation of telomere length

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12 December 2020

T-loops and the origin of telomeres

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12 December 2020

Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body

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12 December 2020

Telomere states and cell fates

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12 December 2020

Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein

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12 December 2020

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

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12 December 2020

Saccharomyces telomeres assume a non-nucleosomal chromatin structure

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12 December 2020

Telomere maintenance and DNA replication: how closely are these two connected?

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12 December 2020

TIN2 mediates functions of TRF2 at human telomeres

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12 December 2020

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

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12 December 2020

The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein

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12 December 2020

Mammalian telomeres end in a large duplex loop

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12 December 2020

Telomere maintenance requires the RAD51D recombination/repair protein

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12 December 2020

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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12 December 2020

A conserved sequence motif within the exceptionally diverse telomeric sequences of budding yeasts

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12 December 2020

Role of mammalian Rad54 in telomere length maintenance

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12 December 2020

Indecent exposure: when telomeres become uncapped

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12 December 2020

10.1007/S00109-004-0616-2

Identifiers

DOI

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11 August 2017

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