(Q36012104)

11 August 2017

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title

Pathological proteins in Parkinson's disease: focus on the proteasome (English)

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11 August 2017

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1

Heather Snyder

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11 August 2017

Benjamin Wolozin

2

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PubMed ID

15655264

11 August 2017

language of work or name

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1 January 2004

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Journal of Molecular Neuroscience

11 August 2017

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11 August 2017

24

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11 August 2017

3

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11 August 2017

425-442

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https://scigraph.springernature.com/pub.10.1385/jmn:24:3:425

11 August 2017

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cites work

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12 December 2020

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

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Impact of ageing on proteasome structure and function in human lymphocytes

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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Genetic analysis of Nurr1 haplotypes in Parkinson's disease

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12 December 2020

Dying back type axonal degeneration of sensory nerve terminals in muscle spindles of the gracile axonal dystrophy (GAD) mutant mouse

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Chaperone-like activity of synucleins

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DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras

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The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

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12 December 2020

Exclusion of the Nurr1 gene in autosomal recessive Parkinson's disease

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12 December 2020

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

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12 December 2020

Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease

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12 December 2020

Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes

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12 December 2020

Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle

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12 December 2020

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12 December 2020

Altered proteasomal function in sporadic Parkinson's disease

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12 December 2020

Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease

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12 December 2020

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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12 December 2020

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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12 December 2020

Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies

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12 December 2020

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

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12 December 2020

NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits.

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12 December 2020

Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss.

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12 December 2020

Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice

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12 December 2020

Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat

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12 December 2020

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

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12 December 2020

Proteasomal function is impaired in substantia nigra in Parkinson's disease

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12 December 2020

The ubiquitin-mediated proteolytic pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins.

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12 December 2020

A role for alpha-synuclein in the regulation of dopamine biosynthesis

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12 December 2020

New mutation (R42P) of the parkin gene in the ubiquitinlike domain associated with parkinsonism

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12 December 2020

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12 December 2020

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

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12 December 2020

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

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12 December 2020

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

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12 December 2020

Paralysis agitans of early onset with marked diurnal fluctuation of symptoms

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12 December 2020

Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease

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12 December 2020

A common NURR1 polymorphism associated with Parkinson disease and diffuse Lewy body disease.

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12 December 2020

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

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12 December 2020

Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

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12 December 2020

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

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12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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12 December 2020

A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

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12 December 2020

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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12 December 2020

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

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12 December 2020

Yeast cells provide insight into alpha-synuclein biology and pathobiology

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12 December 2020

Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions

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12 December 2020

Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary

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12 December 2020

Impairment of the ubiquitin-proteasome system by protein aggregation

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12 December 2020

Beta-synuclein gene alterations in dementia with Lewy bodies

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12 December 2020

Antizyme, a mediator of ubiquitin-independent proteasomal degradation

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12 December 2020

The aetiology of idiopathic Parkinson's disease

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12 December 2020

Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide.

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12 December 2020

SEPT5_v2 is a parkin-binding protein

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12 December 2020

Reciprocal accumulation of β-synuclein in α-synuclein lesions in multiple system atrophy

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12 December 2020

The proteasome: paradigm of a self-compartmentalizing protease

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12 December 2020

Copper(II)-induced self-oligomerization of alpha-synuclein.

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12 December 2020

Progressive degeneration of motor nerve terminals in GAD mutant mouse with hereditary sensory axonopathy

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12 December 2020

Development of a new treatment for Alzheimer's disease and Parkinson's disease using anti-aggregatory beta-synuclein-derived peptides

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12 December 2020

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

1 reference

12 December 2020

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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12 December 2020

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

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12 December 2020

Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells

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12 December 2020

Dopamine neuron agenesis in Nurr1-deficient mice

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12 December 2020

Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins

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12 December 2020

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

12 December 2020

Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease

1 reference

12 December 2020

ACT and UCH-L1 polymorphisms in Parkinson's disease and age of onset.

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12 December 2020

Proteasomes: structure and biology

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12 December 2020

Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination

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12 December 2020

The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase

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12 December 2020

Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

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12 December 2020

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

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12 December 2020

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

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12 December 2020

The multicatalytic and 26 S proteases

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12 December 2020

Alpha-synuclein in Lewy bodies

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12 December 2020

alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

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12 December 2020

The role of pathogenic DJ-1 mutations in Parkinson's disease.

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12 December 2020

Neuropathology in mice expressing human alpha-synuclein

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12 December 2020

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

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12 December 2020

Molecular biology of the proteasome.

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12 December 2020

A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population

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12 December 2020

Alpha-synuclein immunoreactivity is present in axonal swellings in neuroaxonal dystrophy and acute traumatic brain injury

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12 December 2020

DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin

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12 December 2020

Natural substrates of the ubiquitin proteolytic pathway

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12 December 2020

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12 December 2020

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

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12 December 2020

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

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12 December 2020

Mechanism of toxicity in rotenone models of Parkinson's disease

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12 December 2020

Ubiquitin-protein conjugates in Alzheimer's lesions

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12 December 2020

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

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12 December 2020

Autosomal recessive juvenile parkinsonism

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12 December 2020

Synoretin--A new protein belonging to the synuclein family

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12 December 2020

Association of homozygous 7048G7049 variant in the intron six of Nurr1 gene with Parkinson's disease

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12 December 2020

Organization, expression and polymorphism of the human persyn gene

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1385/JMN:24:3:425

1 reference

PubMed ID

15655264

Dimensions Publication ID

11 August 2017

0 references

1 reference

PubMed ID

15655264