(Q36016840)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514270%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Characterization of conformational changes and protein-protein interactions of rod photoreceptor phosphodiesterase (PDE6) (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514270%20AND%20SRC:MED&resulttype=core&format=json

protein-protein interaction

29 January 2020

main subject

photoreceptor protein

0 references

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514270%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

author name string

Suzanne L Matte

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514270%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Thomas M Laue

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514270%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

language of work or name

English

0 references

publication date

18 April 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514270%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

29 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514270%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

volume

287

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514270%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

issue

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514270%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

page(s)

20111-20121

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514270%20AND%20SRC:MED&resulttype=core&format=json

Phosphodiesterase 6D, cGMP-specific rod delta.

29 January 2020

cites work

1 reference

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2 October 2017

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Activation of PDE10 and PDE11 phosphodiesterases

2 October 2017

1 reference

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Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions

2 October 2017

1 reference

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Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation

2 October 2017

1 reference

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Structural characterization of the rod cGMP phosphodiesterase 6.

2 October 2017

1 reference

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Lessons from photoreceptors: turning off g-protein signaling in living cells

2 October 2017

1 reference

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Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights

2 October 2017

1 reference

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Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Membrane protein assembly into Nanodiscs

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Probing the catalytic sites and activation mechanism of photoreceptor phosphodiesterase using radiolabeled phosphodiesterase inhibitors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Naturally occurring animal models with outer retina phenotypes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

The implementation of SOMO (SOlution MOdeller) in the UltraScan analytical ultracentrifugation data analysis suite: enhanced capabilities allow the reliable hydrodynamic modeling of virtually any kind of biomacromolecule

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

The retinal cGMP phosphodiesterase gamma-subunit - a chameleon

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: INSIGHTS INTO NUCLEOTIDE SPECIFICITY, DIMERIZATION, AND cGMP-DEPENDENT CONFORMATIONAL CHANGE

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Signal transducing membrane complexes of photoreceptor outer segments

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Intrinsically disordered -subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structure

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

A model for transport of membrane-associated phototransduction polypeptides in rod and cone photoreceptor inner segments

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Analytical ultracentrifugation for the study of protein association and assembly

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Beyond counting photons: trials and trends in vertebrate visual transduction

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Evaluation of the 17-kDa prenyl-binding protein as a regulatory protein for phototransduction in retinal photoreceptors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Fluorescence detection for the XLI analytical ultracentrifuge

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

The complex of Arl2-GTP and PDE delta: from structure to function

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

G proteins and phototransduction.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

cGMP binding sites on photoreceptor phosphodiesterase: role in feedback regulation of visual transduction.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Reciprocal effects of an inhibitory factor on catalytic activity and noncatalytic cGMP binding sites of rod phosphodiesterase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Measurement of protein using bicinchoninic acid

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Regulation of photoreceptor phosphodiesterase catalysis by its non-catalytic cGMP-binding sites

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Real time conformational changes in the retinal phosphodiesterase gamma subunit monitored by resonance energy transfer.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

An effector site that stimulates G-protein GTPase in photoreceptors.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Reciprocal control of retinal rod cyclic GMP phosphodiesterase by its gamma subunit and transducin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Interactions between the subunits of transducin and cyclic GMP phosphodiesterase in Rana catesbiana rod photoreceptors.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits. A putative regulatory mechanism of the rod photoresponse

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Molecular organization of bovine rod cGMP-phosphodiesterase 6.

11 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

Three-dimensional structure of non-activated cGMP phosphodiesterase 6 and comparison of its image with those of activated forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

The catalytic and GAF domains of the rod cGMP phosphodiesterase (PDE6) heterodimer are regulated by distinct regions of its inhibitory gamma subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

NUTS and BOLTS: applications of fluorescence-detected sedimentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

[3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

SOMO (SOlution MOdeler) differences between X-Ray- and NMR-derived bead models suggest a role for side chain flexibility in protein hydrodynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

Effect of zinc and temperature on the conformation of the gamma subunit of retinal phosphodiesterase: a natively unfolded protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

Phosphorylation of isolated human phosphodiesterase-5 regulatory domain induces an apparent conformational change and increases cGMP binding affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

Allosteric-site and catalytic-site ligand effects on PDE5 functions are associated with distinct changes in physical form of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

Ligand-induced conformational changes in cyclic nucleotide phosphodiesterases and cyclic nucleotide-dependent protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

Direct interaction of the inhibitory gamma-subunit of Rod cGMP phosphodiesterase (PDE6) with the PDE6 GAFa domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

The inhibitory gamma subunit of the rod cGMP phosphodiesterase binds the catalytic subunits in an extended linear structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

A conformational switch in the inhibitory gamma-subunit of PDE6 upon enzyme activation by transducin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354647

Purification, reconstitution on lipid vesicles, and assays of PDE6 and its activator G protein, transducin

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Cyclic guanosine 5'-monophosphate binding to regulatory GAF domains of photoreceptor phosphodiesterase

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Purification of PDE6 isozymes from mammalian retina

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370194

Fluorescence-detected sedimentation in dilute and highly concentrated solutions

23 September 2018

1 reference

12 December 2020

Resolution of transducin subunits by chromatography on blue sepharose

1 reference

12 December 2020

Characterization of the tandem GAF domain of human phosphodiesterase 5 using a cyanobacterial adenylyl cyclase as a reporter enzyme

1 reference

12 December 2020

Kinetics and regulation of cGMP binding to noncatalytic binding sites on photoreceptor phosphodiesterase

1 reference

12 December 2020

Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits

1 reference

12 December 2020

The light-activated GTP-dependent cyclic GMP phosphodiesterase complex of bovine retinal rod outer segments. Dark resolution of the catalytic and regulatory proteins

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M112.354647

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514270%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514270%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

22514270

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22514270%20AND%20SRC:MED&resulttype=core&format=json