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Current status of treatment of spinal and bulbar muscular atrophy (English)

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Fumiaki Tanaka

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Gen Sobue

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases

2 October 2017

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2 October 2017

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Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait

2 October 2017

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Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

2 October 2017

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Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein

2 October 2017

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Transforming growth factor-betas in neurodegenerative disease

2 October 2017

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Toxic and non-toxic aggregates from the SBMA and normal forms of androgen receptor have distinct oligomeric structures.

11 July 2018

1 reference

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Molecular pathophysiology and disease-modifying therapies for spinal and bulbar muscular atrophy.

23 September 2018

1 reference

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Difference in chronological changes of outcome measures between untreated and placebo-treated patients of spinal and bulbar muscular atrophy.

23 September 2018

1 reference

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Autophagy and access: understanding the role of androgen receptor subcellular localization in SBMA.

23 September 2018

1 reference

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17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse

23 September 2018

1 reference

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CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model.

23 September 2018

1 reference

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Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration.

23 September 2018

1 reference

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Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376774

Five year follow up of a patient with spinal and bulbar muscular atrophy treated with leuprorelin

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376774

Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376774

Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

23 September 2018

1 reference

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Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

23 September 2018

1 reference

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Mutant dynactin in motor neuron disease.

23 September 2018

1 reference

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Late onset of obesity in male androgen receptor-deficient (AR KO) mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376774

Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

23 September 2018

1 reference

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Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

23 September 2018

1 reference

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Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

23 September 2018

1 reference

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Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

23 September 2018

1 reference

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Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy

23 September 2018

1 reference

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A Comprehensive Endocrine Description of Kennedy's Disease Revealing Androgen Insensitivity Linked to CAG Repeat Length

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2012%2F369284

Androgen Receptor (AR) Coregulators: An Overview

21 January 2018

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Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity

21 January 2018

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Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

21 January 2018

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12 December 2020

Polyglutamine and CBP: fatal attraction?

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12 December 2020

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

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12 December 2020

Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy

1 reference

12 December 2020

Differential pattern in tissue-specific somatic mosaicism of expanded CAG trinucleotide repeats in dentatorubral-pallidoluysian atrophy, Machado-Joseph disease, and X-linked recessive spinal and bulbar muscular atrophy

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12 December 2020

Founder effect in spinal and bulbar muscular atrophy (SBMA)

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12 December 2020

Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance

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12 December 2020

Dutasteride for spinal and bulbar muscular atrophy

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12 December 2020

Activation Function 2 in the Human Androgen Receptor Ligand Binding Domain Mediates Interdomain Communication with the NH2-terminal Domain

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12 December 2020

Identifiers

DOI

10.1155/2012/369284

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22720173%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22720173%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

22720173

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22720173%20AND%20SRC:MED&resulttype=core&format=json