(Q36076741)

12 August 2017

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title

Gene-targeting technologies for the study of neurological disorders (English)

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12 August 2017

Vassilios Beglopoulos

series ordinal

1

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12 August 2017

Jie Shen

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2

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12 August 2017

language of work or name

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1 January 2004

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12 August 2017

NeuroMolecular Medicine

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12 August 2017

6

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12 August 2017

1

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12 August 2017

13-30

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https://scigraph.springernature.com/pub.10.1385/nmm:6:1:013

12 August 2017

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cites work

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

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12 December 2020

Lessons from animal models of Huntington's disease

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12 December 2020

Ligand-activated site-specific recombination in mice

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12 December 2020

Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination

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12 December 2020

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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12 December 2020

Emerging insights into the genesis of epilepsy

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12 December 2020

Conditional control of gene expression in the mouse

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12 December 2020

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

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12 December 2020

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

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12 December 2020

Inducible site-specific recombination in the brain.

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12 December 2020

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

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12 December 2020

NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation.

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12 December 2020

Using conditional mutagenesis to study the brain.

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12 December 2020

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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12 December 2020

Knockout mice: simple solutions to the problems of genetic background and flanking genes

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12 December 2020

Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS

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12 December 2020

Heterogeneous populations of ES cells in the generation of a floxed Presenilin-1 allele

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12 December 2020

Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1

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12 December 2020

Gene targeting and behaviour: a genetic problem requires a genetic solution

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12 December 2020

mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo

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12 December 2020

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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12 December 2020

The presenilins and Alzheimer's disease

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12 December 2020

Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4.

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12 December 2020

Timing the doxycycline yields different patterns of genomic recombination in brain neurons with a new inducible Cre transgene

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12 December 2020

When reverse genetics meets physiology: the use of site-specific recombinases in mice

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12 December 2020

A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice

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12 December 2020

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

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12 December 2020

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

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12 December 2020

Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins

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12 December 2020

Temporally controlled targeted somatic mutagenesis in the mouse brain

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12 December 2020

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

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12 December 2020

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

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12 December 2020

Mice with reduced NMDA receptor expression display behaviors related to schizophrenia

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12 December 2020

Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice

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12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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12 December 2020

Increased seizure susceptibility and cortical malformation in beta-catenin mutant mice

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12 December 2020

Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory

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12 December 2020

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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12 December 2020

Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin.

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12 December 2020

Calcineurin: form and function

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12 December 2020

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

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12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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12 December 2020

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

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12 December 2020

Skeletal and CNS defects in Presenilin-1-deficient mice

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12 December 2020

Transcriptional activation by tetracyclines in mammalian cells

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12 December 2020

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

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12 December 2020

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

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12 December 2020

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

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12 December 2020

Loss of normal huntingtin function: new developments in Huntington's disease research

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12 December 2020

Initial sequencing and comparative analysis of the mouse genome

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12 December 2020

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

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12 December 2020

Loss of locus coeruleus neurons and reduced startle in parkin null mice

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12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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12 December 2020

Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice

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12 December 2020

Changing colors in mice: an inducible system that delivers

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12 December 2020

CB1 cannabinoid receptors and on-demand defense against excitotoxicity

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12 December 2020

Genetics of Parkinsonism: a review

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12 December 2020

Engineering the mouse genome by site-specific recombination

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12 December 2020

Chemical probe and missing nucleoside analysis of Flp recombinase bound to the recombination target sequence

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12 December 2020

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

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12 December 2020

The biology of epilepsy genes

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12 December 2020

A molecular investigation of true dominance in Huntington's disease

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12 December 2020

Lack of beta-catenin affects mouse development at gastrulation

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12 December 2020

Mouse models of Huntington's disease

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12 December 2020

Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model.

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12 December 2020

Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit

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12 December 2020

Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice

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12 December 2020

Chronic electroconvulsive seizure up-regulates beta-catenin expression in rat hippocampus: role in adult neurogenesis

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12 December 2020

Disruption of CREB function in brain leads to neurodegeneration

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12 December 2020

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

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12 December 2020

Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia

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12 December 2020

Inducible gene targeting in mice

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12 December 2020

Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia

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12 December 2020

Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

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12 December 2020

Inactivation of the mouse Huntington's disease gene homolog Hdh

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12 December 2020

Parkinson's disease. First of two parts

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12 December 2020

Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory.

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12 December 2020

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures.

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12 December 2020

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

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12 December 2020

HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

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12 December 2020

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

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12 December 2020

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

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12 December 2020

Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites

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12 December 2020

Control of memory formation through regulated expression of a CaMKII transgene

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12 December 2020

Identifiers

DOI

10.1385/NMM:6:1:013

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Dimensions Publication ID

12 August 2017

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