(Q36090362)

12 August 2017

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title

Searching sequence space: two different approaches to dihydrofolate reductase catalysis (English)

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12 August 2017

1

Elizabeth E Howell

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12 August 2017

1 April 2005

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12 August 2017

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12 August 2017

6

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12 August 2017

590-600

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12 August 2017

4

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Current status of the aadA and dfr gene cassette families

12 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

A perspective on enzyme catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Preorganization and protein dynamics in enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Stretching exercises--flexibility in dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

NMR Studies of Ligand Binding to Dihydrofolate Reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Structure, dynamics, and catalytic function of dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Network of coupled promoting motions in enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

X-ray Diffraction Study of Binding of 2,3-Diphosphoglycerate to Human Deoxyhaemoglobin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Crystal structure of a novel trimethoprim-resistant dihydrofolate reductase specified in Escherichia coli by R-plasmid R67.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Dynamics of a flexible loop in dihydrofolate reductase from Escherichia coli and its implication for catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Unusual binding stoichiometries and cooperativity are observed during binary and ternary complex formation in the single active pore of R67 dihydrofolate reductase, a D2 symmetric protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Interligand Overhauser effects in type II dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

NMR studies of the interaction of a type II dihydrofolate reductase with pyridine nucleotides reveal unexpected phosphatase and reductase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Matching chemistry and shape in molecular docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Conformation of NADP+ bound to a type II dihydrofolate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Alpha-pyridine nucleotides as substrates for a plasmid-specified dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Functional role of aspartic acid-27 in dihydrofolate reductase revealed by mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Site directed mutagenesis: a tool for enzyme mechanism dissection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Mechanistic studies of R67 dihydrofolate reductase. Effects of pH and an H62C mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Role of ionic interactions in ligand binding and catalysis of R67 dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Effects of single-tryptophan mutations on R67 dihydrofolate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Complementation between dimeric mutants as a probe of dimer-dimer interactions in tetrameric dihydrofolate reductase encoded by R67 plasmid of E. coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Role of S65, Q67, I68, and Y69 residues in homotetrameric R67 dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Breaking symmetry: mutations engineered into R67 dihydrofolate reductase, a D2 symmetric homotetramer possessing a single active site pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Defining the binding site of homotetrameric R67 dihydrofolate reductase and correlating binding enthalpy with catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Role of Lys-32 residues in R67 dihydrofolate reductase probed by asymmetric mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

"Catch 222," the effects of symmetry on ligand binding and catalysis in R67 dihydrofolate reductase as determined by mutations at Tyr-69.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Structural symmetry and protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

On the nature of the multivalency effect: a thermodynamic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

How do mutations at phenylalanine-153 and isoleucine-155 partially suppress the effects of the aspartate-27-->serine mutation in Escherichia coli dihydrofolate reductase?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

A second-site mutation at phenylalanine-137 that increases catalytic efficiency in the mutant aspartate-27----serine Escherichia coli dihydrofolate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Implications for enzymic catalysis from free-energy reaction coordinate profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Evolution of enzyme function and the development of catalytic efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate bound to dihydrofolate reductase: mechanistic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

How dihydrofolate reductase facilitates protonation of dihydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Energetically most likely substrate and active-site protonation sites and pathways in the catalytic mechanism of dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Mechanism of the reaction catalyzed by dihydrofolate reductase from Escherichia coli: pH and deuterium isotope effects with NADPH as the variable substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Role of water in the catalytic cycle of E. coli dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

The electrostatic potential of Escherichia coli dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Changes in the electron density of the cofactor NADPH on binding to E. coli dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Theoretical studies on the dihydrofolate reductase mechanism: electronic polarization of bound substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Electron redistribution on binding of a substrate to an enzyme: folate and dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Binding sites in Escherichia coli dihydrofolate reductase communicate by modulating the conformational ensemble

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Reaction-path energetics and kinetics of the hydride transfer reaction catalyzed by dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Vibrational structure of dihydrofolate bound to R67 dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

An enthalpic component in cooperativity: the relationship between enthalpy, entropy, and noncovalent structure in weak associations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Ligand binding energy and catalytic efficiency from improved packing within receptors and enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Chemical basis for enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

A view at the millennium: the efficiency of enzymatic catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

The depth of chemical time and the power of enzymes as catalysts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

How important are entropic contributions to enzyme catalysis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Ion effects on ligand-nucleic acid interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Quantitative analysis of the effect of salt concentration on enzymatic catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Probing the functional role of phenylalanine-31 of Escherichia coli dihydrofolate reductase by site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Electrostatic origin of the catalytic power of enzymes and the role of preorganized active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Theoretical insights in enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Half-site reactivity, negative cooperativity, and positive cooperativity: quantitative considerations of a plausible model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Symmetry, stability, and dynamics of multidomain and multicomponent protein systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Characterization and stereochemistry of cofactor oxidation by a type II dihydrofolate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Anatomy of protein pockets and cavities: measurement of binding site geometry and implications for ligand design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

The Purification and Properties of the Trimethoprim-Resistant Dihydrofolate Reductase Mediated by the R-Factor, R 388

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Construction of a synthetic gene for an R-plasmid-encoded dihydrofolate reductase and studies on the role of the N-terminus in the protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Dissociation constants for dihydrofolic acid and dihydrobiopterin and implications for mechanistic models for dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

A glutamine 67--> histidine mutation in homotetrameric R67 dihydrofolate reductase results in four mutations per single active site pore and causes substantial substrate and cofactor inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

Direct Measurement of the pKaof Aspartic Acid 26 inLactobacillus caseiDihydrofolate Reductase: Implications for the Catalytic Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400237

21 January 2018

Identifiers

DOI

10.1002/CBIC.200400237

1 reference

12 August 2017

1 reference

PubMed ID

15812782