(Q36201880)

12 August 2017

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title

Apoptosis in amyotrophic lateral sclerosis--what is the evidence? (English)

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amyotrophic lateral sclerosis

12 August 2017

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Pamela J Shaw

2

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author name string

Sivakumar Sathasivam

series ordinal

1

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PubMed ID

16033692

12 August 2017

language of work or name

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1 August 2005

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12 August 2017

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12 August 2017

4

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12 August 2017

8

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12 August 2017

500-509

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Natural history of amyotrophic lateral sclerosis in a database population Validation of a scoring system and a model for survival prediction

12 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Mutant Cu,Zn superoxide dismutases and familial amyotrophic lateral sclerosis: evaluation of oxidative hypotheses

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Protein aggregation in motor neurone disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Mitochondrial involvement in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Defective neurofilament transport in mouse models of amyotrophic lateral sclerosis: a review

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Apoptosis in amyotrophic lateral sclerosis: a review of the evidence.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Programmed cell death in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

An alternative, nonapoptotic form of programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Experimental models of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Neuropathology of ALS: an overview

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Anti-annexin V antibodies in the cerebrospinal fluid and serum of patients with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Neurotrophic effects of annexin V on cultured neurons from embryonic rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Selective vulnerability in amyotrophic lateral sclerosis: no evidence for a contribution of annexins, a family of calcium binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Mechanisms of cell death in neurodegenerative diseases: fashion, fiction, and facts.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Apoptosis in amyotrophic lateral sclerosis is not restricted to motor neurons. Bcl-2 expression is increased in unaffected post-central gyrus

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Motor neuronal death in sporadic amyotrophic lateral sclerosis (ALS) is not apoptotic. A comparative study of ALS and chronic aluminium chloride neurotoxicity in New Zealand white rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

A study of apoptosis in normal and pathologic nervous tissue after in situ end-labeling of DNA strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Lack of apoptosis in mice with ALS

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Apoptotic signaling cascades.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Caspases: killer proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Characterization of the caspase cascade in a cell culture model of SOD1-related familial amyotrophic lateral sclerosis: expression, activation and therapeutic effects of inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Inhibition of ICE slows ALS in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Caspase-1 and -3 mRNAs are differentially upregulated in motor neurons and glial cells in mutant SOD1 transgenic mouse spinal cord: a study using laser microdissection and real-time RT-PCR.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Apoptosis at the time of embryo implantation in mouse and rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Human caspase 12 has acquired deleterious mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Apoptosis signals in sporadic amyotrophic lateral sclerosis: an immunocytochemical study.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Bid acts on the permeability transition pore complex to induce apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Neuroprotective effects of copper/zinc-dependent superoxide dismutase against a wide variety of death-inducing stimuli and proapoptotic effect of familial amyotrophic lateral sclerosis mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Cu,Zn-superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Upregulation of the pro-apoptotic BH3-only peptide harakiri in spinal neurons of amyotrophic lateral sclerosis patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Le(y) antigen expression is correlated with apoptosis (programmed cell death)

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Expression and function of the leucine zipper protein Par-4 in apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Apoptosis by Par-4 in cancer and neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

RNAi knockdown of Par-4 inhibits neurosynaptic degeneration in ALS-linked mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Programmed cell death of embryonic motoneurons triggered through the Fas death receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

In vitro induction of neuronal apoptosis by anti-Fas antibody-containing sera from amyotrophic lateral sclerosis patients.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Serum anti-Fas antibody levels in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

p53-dependent cell death signaling in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Reduction of Purkinje cell pathology in SCA1 transgenic mice by p53 deletion.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Motor neuron cell death in a mouse model of FALS is not mediated by the p53 cell survival regulator.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Minocycline delays disease onset and mortality in a transgenic model of ALS.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Efficient three-drug cocktail for disease induced by mutant superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Controlled trial of nimodipine in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

A clinical trial of verapamil in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

N-methyl-D-aspartate receptor and L-type voltage-gated Ca(2+) channel antagonists suppress the release of cytochrome c and the expression of procaspase-3 in rat hippocampus after global brain ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Amlodipine inhibits doxorubicin-induced apoptosis in neonatal rat cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

An ALS mouse model with a permeable blood-brain barrier benefits from systemic cyclosporine A treatment.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Anti-LFA-1 alpha reduces the dose of cyclosporin A needed to produce immunosuppression in heterotopic cardiac transplanted rats

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Rasagiline alone and in combination with riluzole prolongs survival in an ALS mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

Prospects for antiapoptotic drug therapy of neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970142-3

7 January 2021

10.1016/S1474-4422(05)70142-3

Identifiers

DOI

1 reference

12 August 2017

1 reference

PubMed ID

16033692