(Q36321691)

13 August 2017

1 reference

title

Ubiquitin protein modification and signal transduction: implications for inflammatory bowel diseases (English)

1 reference

inflammatory bowel diseases

13 August 2017

0 references

author name string

Cormac Taylor

series ordinal

1

1 reference

PubMed ID

16306773

13 August 2017

Christian Jobin

series ordinal

2

1 reference

13 August 2017

1 December 2005

1 reference

Inflammatory Bowel Diseases

13 August 2017

1 reference

13 August 2017

11

1 reference

13 August 2017

12

1 reference

13 August 2017

1097-1107

1 reference

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes

13 August 2017

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Back to the future with ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Mechanisms underlying ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Orchestrating nuclear functions: ubiquitin sets the rhythm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Mechanism and function of deubiquitinating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Role of NF-kappaB in immune and inflammatory responses in the gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

NF-kappaB: a key role in inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

The regulation and roles of Rel/NF-kappa B transcription factors during lymphocyte activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

NF-kappaB signaling proteins as therapeutic targets for inflammatory bowel diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Biologic therapy of inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

A beginner's guide to NF-kappaB signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

The role of HIF-1alpha in myeloid cell inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

HIF-1alpha is essential for myeloid cell-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Review: hypoxia-inducible factor-1 (HIF-1): a novel transcription factor in immune reactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Proline hydroxylation and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

HIF-dependent induction of apical CD55 coordinates epithelial clearance of neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Hypoxia inducible factor 1alpha and 2alpha overexpression in inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Oxygen sensing by HIF hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

When hypoxia signalling meets the ubiquitin-proteasomal pathway, new targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

The I kappa B proteins: members of a multifunctional family

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

The NF-kappa B and I kappa B proteins: new discoveries and insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Identification and characterization of an IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

NF-kappaB and the innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

The RIP kinases: crucial integrators of cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

MyD88, an adapter protein involved in interleukin-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

TRAF6 is a signal transducer for interleukin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

IRAK: a kinase associated with the interleukin-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Regulation of Toll-like receptor 4 signalling by A20 zinc finger protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

SUMO protein modification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

SUMO: a history of modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Protein modification by SUMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Hypoxia-responsive transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Cytokines and the regulation of hypoxia-inducible factor (HIF)-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Function of the Yersinia effector YopJ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Drug discovery in the ubiquitin regulatory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000187577.26043.E5

10.1097/01.MIB.0000187577.26043.E5

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16306773