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Isocitrate dehydrogenase mutations in gliomas
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Europe PubMed Central
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4677412
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188014%20AND%20SRC:MED&resulttype=core&format=json
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19 February 2020
review article
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Europe PubMed Central
title
Isocitrate dehydrogenase mutations in gliomas
(English)
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Europe PubMed Central
PMC publication ID
4677412
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188014%20AND%20SRC:MED&resulttype=core&format=json
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19 February 2020
author
Bill H Diplas
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2
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Europe PubMed Central
PMC publication ID
4677412
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19 February 2020
author name string
Matthew S Waitkus
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1
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Europe PubMed Central
PMC publication ID
4677412
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188014%20AND%20SRC:MED&resulttype=core&format=json
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19 February 2020
Hai Yan
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3
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19 February 2020
publication date
16 July 2015
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19 February 2020
published in
Neuro-Oncology
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Europe PubMed Central
PMC publication ID
4677412
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19 February 2020
volume
18
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Europe PubMed Central
PMC publication ID
4677412
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188014%20AND%20SRC:MED&resulttype=core&format=json
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19 February 2020
issue
1
1 reference
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Europe PubMed Central
PMC publication ID
4677412
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retrieved
19 February 2020
page(s)
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19 February 2020
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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
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Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome
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30 September 2017
Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.
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30 September 2017
Mutations in CIC and FUBP1 contribute to human oligodendroglioma
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30 September 2017
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
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2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations
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30 September 2017
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
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30 September 2017
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
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30 September 2017
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.
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IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain
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30 September 2017
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
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30 September 2017
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
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30 September 2017
The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma
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PubMed Central
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30 September 2017
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
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30 September 2017
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
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PubMed Central
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30 September 2017
IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
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30 September 2017
IDH1 and IDH2 mutations in gliomas
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
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30 September 2017
IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
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30 September 2017
Role of cytosolic NADP+-dependent isocitrate dehydrogenase in ischemia-reperfusion injury in mouse kidney
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PubMed Central
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30 September 2017
Analysis of the IDH1 codon 132 mutation in brain tumors
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retrieved
30 September 2017
Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
30 September 2017
An integrated genomic analysis of human glioblastoma multiforme
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
30 September 2017
A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
30 September 2017
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
30 September 2017
MGMT gene silencing and benefit from temozolomide in glioblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
30 September 2017
Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
30 September 2017
Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
30 September 2017
Cellular defense against singlet oxygen-induced oxidative damage by cytosolic NADP+-dependent isocitrate dehydrogenase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
30 September 2017
Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
30 September 2017
Cellular defense against UVB-induced phototoxicity by cytosolic NADP(+)-dependent isocitrate dehydrogenase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
30 September 2017
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
30 September 2017
Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
30 September 2017
IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
28 June 2018
Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
28 June 2018
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
28 June 2018
TP53 Gene Mutations and 17p Deletions in Human Astrocytomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
27 July 2018
A vaccine targeting mutant IDH1 induces antitumour immunity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
The prognostic value of IDH mutations and MGMT promoter status in secondary high-grade gliomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic gliomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
Regulation of replicative senescence by NADP+ -dependent isocitrate dehydrogenase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
Reverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
Alterations of the TP53 gene in human gliomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677412
retrieved
21 September 2018
IL-6 and Akt are involved in muscular pathogenesis in myasthenia gravis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FNEUONC%2FNOV136
retrieved
21 January 2018
Protective role of cytosolic NADP(+)-dependent isocitrate dehydrogenase, IDH1, in ischemic pre-conditioned kidney in mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26188014
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Multiple NADPH-producing pathways control glutathione (GSH) content in retina
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26188014
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1093/NEUONC/NOV136
1 reference
stated in
Europe PubMed Central
PMC publication ID
4677412
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188014%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
PMC publication ID
4677412
1 reference
stated in
Europe PubMed Central
PMC publication ID
4677412
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188014%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
PubMed publication ID
26188014
1 reference
stated in
Europe PubMed Central
PMC publication ID
4677412
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188014%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
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