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The Hedgehog signalling pathway regulates autophagy.
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Europe PubMed Central
PMC publication ID
3514496
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23149744%20AND%20SRC:MED&resulttype=core&format=json
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17 February 2020
title
The Hedgehog signalling pathway regulates autophagy
(English)
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stated in
Europe PubMed Central
PMC publication ID
3514496
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23149744%20AND%20SRC:MED&resulttype=core&format=json
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17 February 2020
main subject
autophagy
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author
Maria Jimenez-Sanchez
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1
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Europe PubMed Central
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3514496
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23149744%20AND%20SRC:MED&resulttype=core&format=json
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17 February 2020
author name string
Fiona M Menzies
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2
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Europe PubMed Central
PMC publication ID
3514496
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23149744%20AND%20SRC:MED&resulttype=core&format=json
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17 February 2020
Yu-Yun Chang
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3
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17 February 2020
Nikol Simecek
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4
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17 February 2020
Thomas P Neufeld
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5
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Europe PubMed Central
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3514496
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17 February 2020
David C Rubinsztein
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6
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3514496
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17 February 2020
language of work or name
English
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publication date
1 January 2012
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Europe PubMed Central
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3514496
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17 February 2020
published in
Nature Communications
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3514496
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17 February 2020
volume
3
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Europe PubMed Central
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17 February 2020
page(s)
1200
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17 February 2020
copyright license
Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
start time
1 January 2012
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https://scigraph.springernature.com/pub.10.1038/ncomms2212
0 references
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Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
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Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
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Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
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The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner
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Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
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Gli1 can rescue the in vivo function of Gli2
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Translational control is required for the unfolded protein response and in vivo glucose homeostasis
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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
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Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
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30 September 2017
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
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30 September 2017
A molecular investigation of true dominance in Huntington's disease
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Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
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30 September 2017
Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells
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A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
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Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog
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Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling
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21 September 2018
FLIP-mediated autophagy regulation in cell death control
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Monitoring autophagic degradation of p62/SQSTM1.
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Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.
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21 September 2018
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.
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21 September 2018
Medulloblastoma growth inhibition by hedgehog pathway blockade
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Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.
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Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development
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21 September 2018
Identifiers
DOI
10.1038/NCOMMS2212
1 reference
stated in
Europe PubMed Central
PMC publication ID
3514496
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23149744%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 February 2020
ADS bibcode
2012NatCo...3.1200J
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PMC publication ID
3514496
1 reference
stated in
Europe PubMed Central
PMC publication ID
3514496
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23149744%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 February 2020
PubMed publication ID
23149744
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stated in
Europe PubMed Central
PMC publication ID
3514496
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23149744%20AND%20SRC:MED&resulttype=core&format=json
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17 February 2020
ResearchGate publication ID
233411348
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