(Q36477475)

14 August 2017

1 reference

title

Recent medicinal chemistry of the histamine H3 receptor (English)

1 reference

14 August 2017

Michael A Letavic

1

1 reference

14 August 2017

Ann J Barbier

series ordinal

2

1 reference

14 August 2017

Curt A Dvorak

series ordinal

3

1 reference

14 August 2017

Nicholas I Carruthers

series ordinal

4

1 reference

14 August 2017

publication date

1 January 2006

1 reference

Progress in medicinal chemistry

14 August 2017

published in

1 reference

14 August 2017

volume

44

1 reference

14 August 2017

page(s)

181-206

1 reference

Genetic and pharmacological aspects of histamine H3 receptor heterogeneity

14 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Perspectives on cognitive domains, H3 receptor ligands and neurological disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Selective histamine H3 receptor antagonists for treatment of cognitive deficiencies and other disorders of the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Presynaptic H3 autoreceptors modulate histamine synthesis through cAMP pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

The physiology of brain histamine.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Involvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the cat.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Sleep and waking during acute histamine H3 agonist BP 2.94 or H3 antagonist carboperamide (MR 16155) administration in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Histamine H(3) receptors mediate inhibition of noradrenaline release from intestinal sympathetic nerves

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Histamine H3 receptor activation inhibits glutamate release from rat striatal synaptosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Histamine H3-receptors inhibit cholinergic neurotransmission in guinea-pig airways

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Histamine H3-receptor isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Identification of rat H3 receptor isoforms with different brain expression and signaling properties.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H(3) receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Alternative splicing of the histamine H(3) receptor mRNA at the third cytoplasmic loop is not detectable in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Molecular and pharmacological characterization of the mouse histamine H3 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A).

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Histamine H3-receptor-mediated [35S]GTP gamma[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

High constitutive activity of native H3 receptors regulates histamine neurons in brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Protean agonism at histamine H3 receptors in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Inverse, protean, and ligand-selective agonism: matters of receptor conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Functional identification of histamine H3-receptors in the human heart

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Activation of histamine H3-receptors inhibits carrier-mediated norepinephrine release during protracted myocardial ischemia. Comparison with adenosine A1-receptors and alpha2-adrenoceptors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Increased severity of reperfusion arrhythmias in mouse hearts lacking histamine H3-receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Aminopyridine inhibition and voltage dependence of K+ currents in smooth muscle cells from cerebral arteries

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

The H3 receptor is involved in cholecystokinin inhibition of food intake in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Effects of intracerebroventricularly infused histamine and selective H1, H2 and H3 agonists on food and water intake and urine flow in Wistar rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Effect of an inhaled histamine H3-receptor agonist on airway responses to sodium metabisulphite in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Nalpha-methylhistamine safety and efficacy in migraine prophylaxis: phase I and phase II studies

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Activation of spinal histamine H3 receptors inhibits mechanical nociception

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Rodent antinociception following acute treatment with different histamine receptor agonists and antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Pruritus-associated response mediated by cutaneous histamine H3 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Involvement of histamine H3 receptors in scratching behaviour in mast cell-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Pharmacological aspects of human and canine narcolepsy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Enhancement of prepulse inhibition of startle in mice by the H3 receptor antagonists thioperamide and ciproxifan

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Increased brain histamine in an alcohol-preferring rat line and modulation of ethanol consumption by H(3) receptor mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Behavioral characterization of mice lacking histamine H(3) receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Pharmacological evaluation of an in vivo model of vestibular dysfunction in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Effect of thioperamide, a histamine H3 receptor antagonist, on electrically induced convulsions in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

The histamine H3 receptor: from gene cloning to H3 receptor drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

An efficient multigram synthesis of the potent histamine H3 antagonist GT-2331 and the reassessment of the absolute configuration

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687).

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

4-Chlorobenzyl sulfonamide and sulfamide derivatives of histamine homologues: the design of potent histamine H3 receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

From histamine to imidazolylalkyl-sulfonamides: the design of a novel series of histamine H3-receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Design, synthesis, and structure-activity relationships of novel non-imidazole histamine H(3) receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

omega-(Imidazol-4-yl)alkane-1-sulfonamides: a new series of potent histamine H(3) receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Novel H3 receptor antagonists. Sulfonamide homologs of histamine.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Piperidino-hydrocarbon compounds as novel non-imidazole histamine H(3)-receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 2: binding preference for D-amino acids motifs

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Synthesis and evaluation of potent pyrrolidine H(3) antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

A new class of histamine H(3)-receptor antagonists: synthesis and structure-activity relationships of 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolines

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

1 reference

7 January 2021

Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Novel human histamine H(3) receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Non-imidazole heterocyclic histamine H3 receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

4-phenoxypiperidines: potent, conformationally restricted, non-imidazole histamine H3 antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

A scalable synthesis of a histamine H3 receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

1-alkyl-4-acylpiperazines as a new class of imidazole-free histamine H(3) receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Cinnamic amides of (S)-2-(aminomethyl)pyrrolidines are potent H3 antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Non-imidazole histamine H3 ligands. Part III. New 4-n-propylpiperazines as non-imidazole histamine H3-antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Search for histamine H(3) receptor ligands with combined inhibitory potency at histamine N-methyltransferase: omega-piperidinoalkanamine derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Histamine H3 receptor agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Cyclopropane-Based Conformational Restriction of Histamine. (1S,2S)-2-(2-Aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a Highly Selective Agonist for the Histamine H3 Receptor, Having a cis-Cyclopropane Structure

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

The histamine H3 receptor and its ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2805%2944405-7

7 January 2021

10.1016/S0079-6468(05)44405-7

Identifiers

DOI

1 reference

14 August 2017

1 reference