(Q36528609)

14 August 2017

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title

Cellular and molecular mechanisms of Parkinson's disease: neurotoxins, causative genes, and inflammatory cytokines (English)

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14 August 2017

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Toshi Nagatsu

1

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14 August 2017

Makoto Sawada

series ordinal

2

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14 August 2017

publication date

6 July 2006

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Cellular and Molecular Neurobiology

14 August 2017

published in

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14 August 2017

volume

26

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14 August 2017

issue

4-6

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14 August 2017

page(s)

781-802

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https://scigraph.springernature.com/pub.10.1007/s10571-006-9061-9

14 August 2017

exact match

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cites work

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10571-006-9061-9

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10571-006-9061-9

Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.

21 January 2018

1 reference

12 December 2020

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

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12 December 2020

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12 December 2020

Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene

1 reference

12 December 2020

Neurocirculatory abnormalities in Parkinson disease with orthostatic hypotension: independence from levodopa treatment

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12 December 2020

Pathogenesis and preclinical course of Parkinson's disease

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12 December 2020

The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

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12 December 2020

Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

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12 December 2020

1-Methyl-1,2,3,4-tetrahydroisoquinoline, decreasing in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse, prevents parkinsonism-like behavior abnormalities.

1 reference

12 December 2020

Oxidative stress and nitration in neurodegeneration: cause, effect, or association?

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12 December 2020

Molecular biology of catecholamine-related enzymes in relation to Parkinson's disease.

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12 December 2020

Isoquinoline neurotoxins in the brain and Parkinson's disease

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12 December 2020

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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12 December 2020

Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease

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12 December 2020

DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras

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12 December 2020

Dopaminergic neurons degenerate by apoptosis in Parkinson's disease.

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12 December 2020

Regulation of alpha-synuclein expression: implications for Parkinson's disease

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12 December 2020

Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice on interleukin-1beta and nerve growth factor in the striatum

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12 December 2020

Molecular pathogenesis of Parkinson's disease

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12 December 2020

The occurrence, distribution and physiological role of catecholamines in the nervous system

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12 December 2020

Genes in familial parkinsonism and their role in sporadic Parkinson's disease.

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12 December 2020

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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12 December 2020

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

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12 December 2020

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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12 December 2020

Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

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12 December 2020

Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

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12 December 2020

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

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12 December 2020

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

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12 December 2020

Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo.

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12 December 2020

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

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12 December 2020

Mitochondrial dysfunction in Parkinson's disease

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12 December 2020

The physiological disposition of H3-epinephrine and its metabolite metanephrine

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12 December 2020

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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12 December 2020

Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains

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12 December 2020

2-Methyl-1,2,3,4-tetrahydroisoquinoline does dependently reduce the number of tyrosine hydroxylase-immunoreactive cells in the substantia nigra and locus ceruleus of C57BL/6J mice

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12 December 2020

beta-Carbolinium cations, endogenous MPP+ analogs, in the lumbar cerebrospinal fluid of patients with Parkinson's disease

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12 December 2020

Neuroprotection by deprenyl and other propargylamines: glyceraldehyde-3-phosphate dehydrogenase rather than monoamine oxidase B

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12 December 2020

Protein kinases linked to the pathogenesis of Parkinson's disease

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12 December 2020

Dopamine covalently modifies and functionally inactivates parkin

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12 December 2020

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

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12 December 2020

Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism

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12 December 2020

The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease

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12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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12 December 2020

alpha-Synuclein locus triplication causes Parkinson's disease

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12 December 2020

Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies.

1 reference

12 December 2020

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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12 December 2020

TGFbeta1 and TGFbeta2 concentrations are elevated in Parkinson's disease in ventricular cerebrospinal fluid.

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12 December 2020

Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients

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12 December 2020

Identification of a potential nurr1 response element that activates the tyrosine hydroxylase gene promoter in cultured cells

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12 December 2020

Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system

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12 December 2020

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

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12 December 2020

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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12 December 2020

Tyrosine hydroxylase deficiency causes progressive encephalopathy and dopa-nonresponsive dystonia.

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12 December 2020

Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease

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12 December 2020

Presence of methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, derivatives of the neurotoxin isoquinoline, in parkinsonian lumbar CSF.

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12 December 2020

Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry

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12 December 2020

Molecular genetics of dopa-responsive dystonia

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12 December 2020

Mitochondria in the etiology and pathogenesis of Parkinson's disease

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12 December 2020

Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra?

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12 December 2020

Neurotrophins and cytokines in Parkinson's disease.

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12 December 2020

New movement in Parkinson's

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12 December 2020

Neuroscience: while you were sleeping.

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12 December 2020

Changes in cytokines and neurotrophins in Parkinson's disease

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12 December 2020

Upregulation of the anti-apoptotic protein Bcl-2 may be an early event in neurodegeneration: studies on Parkinson's and incidental Lewy body disease

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12 December 2020

Genetic clues to the pathogenesis of Parkinson's disease

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12 December 2020

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

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12 December 2020

Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains

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12 December 2020

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12 December 2020

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

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12 December 2020

Unraveling the pathogenesis of Parkinson's disease--the contribution of monogenic forms

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12 December 2020

1‐Benzyl‐1,2,3,4‐Tetrahydroisoquinoline as a Parkinsonism‐Inducing Agent: A Novel Endogenous Amine in Mouse Brain and Parkinsonian CSF

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12 December 2020

Cytokines in Parkinson's disease

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12 December 2020

Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs

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12 December 2020

The HIV-1 Nef protein and phagocyte NADPH oxidase activation

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12 December 2020

Initiation of neuronal damage by complex I deficiency and oxidative stress in Parkinson's disease.

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12 December 2020

The biochemistry of Parkinson's disease

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12 December 2020

The ubiquitin pathway in Parkinson's disease

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12 December 2020

Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients

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12 December 2020

O-Methylation of Epinephrine and Other Catechols in vitro and in vivo

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12 December 2020

Alpha-synuclein: normal function and role in neurodegenerative diseases.

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12 December 2020

A Drosophila model of Parkinson's disease

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12 December 2020

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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12 December 2020

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

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12 December 2020

New genetic insights into Parkinson's disease

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12 December 2020

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

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12 December 2020

Alpha-synuclein and neurodegenerative diseases

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12 December 2020

An endogenous dopaminergic neurotoxin: implication for Parkinson's disease

1 reference

12 December 2020

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease.

1 reference

12 December 2020

Inflammatory process in Parkinson's disease: role for cytokines

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12 December 2020

Multiple mechanisms of cytokine action in neurodegenerative and psychiatric states: neurochemical and molecular substrates

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12 December 2020

Mutations in NR4A2 associated with familial Parkinson disease

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12 December 2020

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

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12 December 2020

Parkinson's disease: changes in apoptosis-related factors suggesting possible gene therapy

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12 December 2020

Autosomal dominant guanosine triphosphate cyclohydrolase I deficiency (Segawa disease).

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12 December 2020

Altered brain metabolism of iron as a cause of neurodegenerative diseases?

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12 December 2020

Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains.

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12 December 2020

Molecular genetics of tyrosine 3-monooxygenase and inherited diseases

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12 December 2020

Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency

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12 December 2020

ICE-like proteases in apoptosis

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12 December 2020

Staging of brain pathology related to sporadic Parkinson's disease

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12 December 2020

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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12 December 2020

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

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12 December 2020

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12 December 2020

Pharmacological actions of 6-hydroxydopamine

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12 December 2020

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

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12 December 2020

bcl-2 protein is increased in the brain from parkinsonian patients

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12 December 2020

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

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12 December 2020

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

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12 December 2020

Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication

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12 December 2020

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

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12 December 2020

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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12 December 2020

Elevated levels of harman and norharman in cerebrospinal fluid of parkinsonian patients

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12 December 2020

Parkinson's disease: mechanisms and models

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12 December 2020

10.1007/S10571-006-9061-9

Identifiers

DOI

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14 August 2017

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