(Q36750717)

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Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant

scientific article published on 10 December 2015

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2 March 2020

Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant (English)

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2 March 2020

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Brett W Stringer

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2 March 2020

Annette T. Byrne

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2 March 2020

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2 March 2020

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Z Zakaria

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2 March 2020

A Tivnan

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2 March 2020

L Flanagan

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2 March 2020

D W Murray

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2 March 2020

M Salvucci

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2 March 2020

B W Day

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2 March 2020

A W Boyd

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2 March 2020

D Kögel

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2 March 2020

M Rehm

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2 March 2020

D F O'Brien

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2 March 2020

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10 December 2015

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2 March 2020

British Journal of Cancer

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2 March 2020

114

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2 March 2020

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2 March 2020

188-198

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2 March 2020

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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International

10 December 2015

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April 2022 Public Data File from Crossref

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https://scigraph.springernature.com/pub.10.1038/bjc.2015.420

0 references

PEITC induces apoptosis of Human Brain Glioblastoma GBM8401 Cells through the extrinsic- and intrinsic -signaling pathways

1 reference

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29 September 2017

Combination effects of SMAC mimetic birinapant with TNFα, TRAIL, and docetaxel in preclinical models of HNSCC.

1 reference

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29 September 2017

Small-molecule SMAC mimetics as new cancer therapeutics

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Micro-environment causes reversible changes in DNA methylation and mRNA expression profiles in patient-derived glioma stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4815807

29 September 2017

Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4815807

29 September 2017

Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents

1 reference

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29 September 2017

Molecular pathways: targeting inhibitor of apoptosis proteins in cancer--from molecular mechanism to therapeutic application

1 reference

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29 September 2017

The tumor suppressor microRNA, miR-124a, is regulated by epigenetic silencing and by the transcriptional factor, REST in glioblastoma

1 reference

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29 September 2017

Temozolomide down-regulates P-glycoprotein in human blood-brain barrier cells by disrupting Wnt3 signaling

1 reference

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Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach

1 reference

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29 September 2017

The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells

1 reference

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29 September 2017

Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.

1 reference

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29 September 2017

DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis

1 reference

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29 September 2017

Standard of care therapy for malignant glioma and its effect on tumor and stromal cells

1 reference

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The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

1 reference

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Targeting IAPs as an approach to anti-cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4815807

29 September 2017

Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4815807

29 September 2017

Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma

1 reference

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29 September 2017

Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens

1 reference

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The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma

1 reference

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29 September 2017

Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

1 reference

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1 reference

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29 September 2017

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

1 reference

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

1 reference

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Prognostic factors for survival in 676 consecutive patients with newly diagnosed primary glioblastoma

1 reference

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Pharmacological inhibition of Bcl-2 family members reactivates TRAIL-induced apoptosis in malignant glioma

1 reference

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The 2007 WHO classification of tumours of the central nervous system

1 reference

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1 reference

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1 reference

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1 reference

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Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/26657652

12 December 2020

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10.1038/BJC.2015.420

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26657652%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26657652%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26657652%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

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