(Q37302745)

19 August 2017

1 reference

title

IAP-targeted therapies for cancer (English)

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19 August 2017

E C LaCasse

1

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19 August 2017

D J Mahoney

2

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19 August 2017

H H Cheung

3

1 reference

19 August 2017

S Plenchette

4

1 reference

19 August 2017

S Baird

5

1 reference

19 August 2017

R G Korneluk

6

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19 August 2017

language of work or name

English

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publication date

1 October 2008

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19 August 2017

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19 August 2017

27

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19 August 2017

6252-6275

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19 August 2017

48

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https://scigraph.springernature.com/pub.10.1038/onc.2008.302

19 August 2017

0 references

cites work

Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2

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The molecular basis and potential role of survivin in cancer diagnosis and therapy

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Survivin, cancer networks and pathway-directed drug discovery.

21 January 2018

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A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

21 January 2018

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Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.302

Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Selective Expansion of Marginal Zone B Cells in Eμ-API2-MALT1 Mice Is Linked to Enhanced IκB Kinase γ Polyubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.302

Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.302

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Nuclear and cytoplasmic cellular distribution of survivin as survival predictor in resected non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.302

XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.302

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.302

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Tetra-O-methyl nordihydroguaiaretic acid induces growth arrest and cellular apoptosis by inhibiting Cdc2 and survivin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

A human IAP-family gene, apollon, expressed in human brain cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

X-linked inhibitor of apoptosis antagonism: strategies in cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: a role for the IAPs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The RING domain of cIAP1 mediates the degradation of RING-bearing inhibitor of apoptosis proteins by distinct pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Isoform-specific silencing of the Livin gene by RNA interference defines Livin beta as key mediator of apoptosis inhibition in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

IAPs as a target for anticancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Novel therapeutic targets in lung cancer: Inhibitor of apoptosis proteins from laboratory to clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

X-linked IAP is a direct inhibitor of cell-death proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

An IAP-IAP complex inhibits apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

MALT lymphoma : recent advances in aetiology and molecular genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The mitochondrial death squad: hardened killers or innocent bystanders?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Homodimerization antagonizes nuclear export of survivin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Nuclear factor-kappa B regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Proliferation, cell cycle and apoptosis in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Regulation of survivin function by Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Smac3, a Novel Smac/DIABLO Splicing Variant, Attenuates the Stability and Apoptosis-inhibiting Activity of X-linked Inhibitor of Apoptosis Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Survivin, a cancer target with an emerging role in normal adult tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Antisense oligonucleotides as therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Antisense therapy: current status in prostate cancer and other malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The proapoptotic protein Smac/DIABLO dimer has the highest stability as measured by pressure and urea denaturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Inhibition of melanoma tumor growth in vivo by survivin targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

AICAR inhibits proliferation and induced S-phase arrest, and promotes apoptosis in CaSki cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Lingering mysteries of ubiquitin-chain assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Involvement of two NF-kappa B binding elements in tumor necrosis factor alpha -, CD40-, and epstein-barr virus latent membrane protein 1-mediated induction of the cellular inhibitor of apoptosis protein 2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Anti-apoptotic action of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Terminally differentiated neutrophils predominantly express Survivin-2 alpha, a dominant-negative isoform of survivin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Survivin-dependent and -independent pathways and the induction of cancer cell death by tetra-O-methyl nordihydroguaiaretic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The inhibitors of apoptosis (IAPs) as cancer targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The age of crosstalk: phosphorylation, ubiquitination, and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Antisense therapy for cancer--the time of truth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Participation of Survivin in mitotic and apoptotic activities of normal and tumor-derived cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Intracellular NOD-like receptors in host defense and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The effects of knockdown of wild-type survivin, survivin-2B or survivin-delta3 on the radiosensitization in a soft tissue sarcoma cells in vitro under different oxygen conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Livin, a novel inhibitor of apoptosis protein family member

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

LKB1 and AMPK and the regulation of skeletal muscle metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Application of XIAP antisense to cancer and other proliferative disorders: development of AEG35156/ GEM640

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Genomic organization of the X-linked inhibitor of apoptosis and identification of a novel testis-specific transcript

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The inhibitors of apoptosis: there is more to life than Bcl2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

XIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

A dual role for the API2 moiety in API2-MALT1-dependent NF-kappaB activation: heterotypic oligomerization and TRAF2 recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Transfection of Smac/DIABLO sensitizes drug-resistant tumor cells to TRAIL or paclitaxel-induced apoptosis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Cancer gene therapy using a survivin mutant adenovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Exonization of Alu-generated splice variants in the survivin gene of human and non-human primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Splice variants of mIAP1 have an enhanced ability to inhibit apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Manipulation of NK cytotoxicity by the IAP family member Livin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Protein-protein recognition as a first step towards the inhibition of XIAP and Survivin anti-apoptotic proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Translocation of the inhibitor of apoptosis protein c-IAP1 from the nucleus to the Golgi in hematopoietic cells undergoing differentiation: a nuclear export signal-mediated event

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Rational design of shepherdin, a novel anticancer agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Final stages of cytokinesis and midbody ring formation are controlled by BRUCE

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Potent antitumor efficacy of XAF1 delivered by conditionally replicative adenovirus vector via caspase-independent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

XIAP expression is an independent prognostic marker in clear-cell renal carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Incidence and subtype specificity of API2-MALT1 fusion translocations in extranodal, nodal, and splenic marginal zone lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Chromosomal passengers: conducting cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Antigen-receptor signaling to nuclear factor kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Survivin inhibition induces human neural tumor cell death through caspase-independent and -dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

ASD: a bioinformatics resource on alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

NLRs at the intersection of cell death and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

IAPs, RINGs and ubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The inhibitor of apoptosis proteins as therapeutic targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

HSF1 down-regulates XAF1 through transcriptional regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

All-trans retinoic acid induces XAF1 expression through an interferon regulatory factor-1 element in colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

TNF-alpha induces two distinct caspase-8 activation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

CARD-Bcl10-Malt1 signalosomes: missing link to NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Caspase-3 and inhibitor of apoptosis protein(s) interactions in Saccharomyces cerevisiae and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Structural basis of IAP recognition by Smac/DIABLO

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Expression of IAP family proteins in myelodysplastic syndromes transforming to overt leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Disturbed balance of expression between XIAP and Smac/DIABLO during tumour progression in renal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Cell division and cell survival in the absence of survivin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

AMPK activation with AICAR provokes an acute fall in plasma [K+].

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Small-Molecule Targeting of Heat Shock Protein 90 Chaperone Function: Rational Identification of a New Anticancer Lead

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Activated intrinsic apoptosis pathway is a key related prognostic parameter in acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

CIAP2 inhibits anigen receptor signaling by targeting Bcl10 for degredation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Role of survivin, whose gene is mapped to 17q25, in human neuroblastoma and identification of a novel dominant-negative isoform, survivin-beta/2B

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Nuclear expression of survivin is associated with improved survival in metastatic ovarian carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Role of survivin and its splice variants in tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Dealing the CARDs between life and death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Non-peptidic small molecule inhibitors of XIAP

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Nuclear survivin is associated with disease recurrence and poor survival in patients with cutaneous malignant melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Do the survivin (BIRC5) splice variants modulate or add to the prognostic value of total survivin in breast cancer?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Marginal-zone B-cell lymphoma of extranodal mucosa-associated lymphoid tissue type: molecular genetics provides new insights into pathogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Immunocytochemical detection of XIAP in body cavity effusions and washes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Survivin nuclear labeling index: a superior biomarker in superficial urothelial carcinoma of human urinary bladder.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.302

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/ONC.2008.302

1 reference

19 August 2017

1 reference