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Nurr1-Based Therapies for Parkinson's Disease.
scientific article published on 25 March 2016
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scholarly article
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Europe PubMed Central
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4833611
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27012974%20AND%20SRC:MED&resulttype=core&format=json
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31 March 2020
title
Nurr1-Based Therapies for Parkinson's Disease
(English)
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stated in
Europe PubMed Central
PMCID
4833611
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27012974%20AND%20SRC:MED&resulttype=core&format=json
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31 March 2020
main subject
Parkinson's disease
1 reference
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inferred from title
author
Song Li
series ordinal
2
1 reference
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Europe PubMed Central
PMCID
4833611
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27012974%20AND%20SRC:MED&resulttype=core&format=json
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31 March 2020
Huaibin Cai
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4
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Europe PubMed Central
PMCID
4833611
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27012974%20AND%20SRC:MED&resulttype=core&format=json
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31 March 2020
author name string
Jie Dong
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1
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4833611
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27012974%20AND%20SRC:MED&resulttype=core&format=json
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31 March 2020
Jing-Lin Mo
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3
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4833611
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31 March 2020
Wei-Dong Le
series ordinal
5
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Europe PubMed Central
PMCID
4833611
reference URL
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31 March 2020
publication date
25 March 2016
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Europe PubMed Central
PMCID
4833611
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31 March 2020
published in
CNS Neuroscience & Therapeutics
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Europe PubMed Central
PMCID
4833611
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31 March 2020
volume
22
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4833611
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31 March 2020
issue
5
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Europe PubMed Central
PMCID
4833611
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31 March 2020
page(s)
351-359
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Europe PubMed Central
PMCID
4833611
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27012974%20AND%20SRC:MED&resulttype=core&format=json
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31 March 2020
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Treatment of Parkinson disease with C17.2 neural stem cells overexpressing NURR1 with a recombined republic-deficit adenovirus containing the NURR1 gene
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Nurr1 in Parkinson's disease and related disorders
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Biological effects of pramipexole on dopaminergic neuron-associated genes: relevance to neuroprotection.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Cabergoline stimulates synthesis and secretion of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor by mouse astrocytes in primary culture
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Identification of the Antineoplastic Agent 6-Mercaptopurine as an Activator of the Orphan Nuclear Hormone Receptor Nurr1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Function and regulation of CREB family transcription factors in the nervous system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Orphan nuclear receptors: from gene to function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Mechanical agitation induces gene expression of NOR-1 and its closely related orphan nuclear receptors in leukemic cell lines
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Dopamine neuron agenesis in Nurr1-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
1,25-Dihydroxyvitamin D3, an inducer of glial cell line-derived neurotrophic factor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
29 September 2017
Retinoids induce Nur77-dependent apoptosis in mouse thymocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
27 June 2018
Wnt/β-catenin signaling is required to rescue midbrain dopaminergic progenitors and promote neurorepair in ageing mouse model of Parkinson's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
27 June 2018
Nurr1 protein is required for N-methyl-D-aspartic acid (NMDA) receptor-mediated neuronal survival
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
27 June 2018
Three related brain nuclear receptors, NGFI-B, Nurr1, and NOR-1, as transcriptional activators
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
27 June 2018
Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Analysis of clinical evaluation of response to treatment of Parkinson's disease with integrated Chinese and Western medicine therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Transplantation of neural stem cells co-transfected with Nurr1 and Brn4 for treatment of Parkinsonian rats.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Ginkgo biloba extract (EGb 761) modulates the expression of dopamine-related genes in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Anti-parkinsonian effects of Nurr1 activator in ubiquitin-proteasome system impairment induced animal model of Parkinson's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Docosahexaenoic acid promotes dopaminergic differentiation in induced pluripotent stem cells and inhibits teratoma formation in rats with Parkinson-like pathology.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
VEGF stimulates PKD-mediated CREB-dependent orphan nuclear receptor Nurr1 expression: role in VEGF-induced angiogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Generation of functional dopamine neurons from neural precursor cells isolated from the subventricular zone and white matter of the adult rat brain using Nurr1 overexpression.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Analysis of alpha-synuclein, dopamine and parkin pathways in neuropathologically confirmed parkinsonian nigra.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Acquisition of in vitro and in vivo functionality of Nurr1-induced dopamine neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Identification of a series of highly potent activators of the Nurr1 signaling pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Age-dependent dopaminergic dysfunction in Nurr1 knockout mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Dopamine and serotonin interactions in the modulation of the expression of the immediate-early transcription factor, nerve growth factor-inducible B, in the striatum.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4833611
retrieved
5 September 2018
Proteasomal inhibition as a treatment strategy for Parkinson's disease: the impact of α-synuclein on Nurr1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27012974
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Intrastriatal transplantation of microcarrier-bound human retinal pigment epithelial cells versus sham surgery in patients with advanced Parkinson's disease: a double-blind, randomised, controlled trial
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27012974
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A high-efficiency induction of dopaminergic cells from human umbilical mesenchymal stem cells for the treatment of hemiparkinsonian rats
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27012974
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27012974
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Characterization of the Nurr1 ligand-binding domain co-activator interaction surface
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27012974
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Pathogenesis of Parkinson's disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27012974
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
MicroRNAs in Parkinson's disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27012974
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Effect of Bushen Huoxue Decoction on the orphan receptor and tyrosine hydroxylase in the brain of rats with Parkinson's disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27012974
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1111/CNS.12536
1 reference
stated in
Europe PubMed Central
PMCID
4833611
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27012974%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
PMCID
4833611
1 reference
stated in
Europe PubMed Central
PMCID
4833611
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27012974%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
PubMed ID
27012974
1 reference
stated in
Europe PubMed Central
PMCID
4833611
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27012974%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
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