(Q36832450)

16 August 2017

1 reference

title

Paclitaxel and docetaxel resistance: molecular mechanisms and development of new generation taxanes (English)

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16 August 2017

1 reference

1 reference

4

Maurizio Botta

1 reference

16 August 2017

Elena Galletti

1

1 reference

16 August 2017

Matteo Magnani

series ordinal

2

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16 August 2017

Michela L Renzulli

series ordinal

3

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16 August 2017

language of work or name

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1 July 2007

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16 August 2017

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16 August 2017

volume

2

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16 August 2017

issue

7

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16 August 2017

page(s)

920-942

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Recent progress in structure activity relationship and mechanistic studies of taxol analogues

16 August 2017

cites work

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Mutations of oncoprotein 18/stathmin identify tubulin-directed regulatory activities distinct from tubulin association

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Characterization of a taxol-resistant human small-cell lung cancer cell line

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Mechanism of action of taxol

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7 January 2021

Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

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7 January 2021

Mechanisms of Taxol resistance related to microtubules.

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7 January 2021

Mechanisms of drug resistance in cancer chemotherapy

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7 January 2021

Paclitaxel resistance: molecular mechanisms and pharmacologic manipulation

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7 January 2021

Molecular mechanisms of resistance to taxanes and therapeutic implications

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7 January 2021

Multidrug resistance in cancer: role of ATP-dependent transporters

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7 January 2021

An inventory of the human ABC proteins

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7 January 2021

The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research

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7 January 2021

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

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7 January 2021

Breast cancer resistance protein (BCRP/ABCG2) is expressed by progenitor cells/reactive ductules and hepatocytes and its expression pattern is influenced by disease etiology and species type: possible functional consequences

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7 January 2021

Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.

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7 January 2021

Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen

1 reference

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7 January 2021

Amplification of the mdr1-gene is uncommon in recurrent ovarian carcinomas.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Altered expression of M beta 2, the class II beta-tubulin isotype, in a murine J774.2 cell line with a high level of taxol resistance

1 reference

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7 January 2021

The Role of ABC Transporters in Clinical Practice

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7 January 2021

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

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https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Anticancer multidrug resistance mediated by MRP1: recent advances in the discovery of reversal agents

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

MRP gene overexpression in a human doxorubicin-resistant SCLC cell line: alterations in cellular pharmacokinetics and in pattern of cross-resistance.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Role of the breast cancer resistance protein (ABCG2) in drug transport

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Targeting multidrug resistance in cancer

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Pharmacological strategies for overcoming multidrug resistance

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

The medicinal chemistry of multidrug resistance (MDR) reversing drugs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Transmembrane inhibitors of P-glycoprotein, an ABC transporter

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

An update on overcoming MDR1-mediated multidrug resistance in cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Reversal of cancer multidrug resistance by green tea polyphenols

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Recent developments in the chemical biology of epothilones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Targeting cancer cells by exploiting their resistance

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Biological activity and chemistry of taxoids from the Japanese yew, Taxus cuspidata.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Neutral taxoids from Taxus cuspidata as modulators of multidrug-resistant tumor cells.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Bioactive taxoids from the Japanese yew Taxus cuspidata.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Effects of taxoids from Taxus cuspidata on microtubule depolymerization and vincristine accumulation in MDR cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Modulation of multidrug resistance by taxuspine C and other taxoids from Japanese yew

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Production of biologically active taxoids by a callus culture of Taxus cuspidata

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

A new taxoid from a callus culture of Taxus cuspidata as an MDR reversal agent

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Taxoids and abietanes from callus cultures of Taxus cuspidata

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthetic studies with 13-deoxybaccatin III.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthesis and biological evaluation of taxinine analogues as orally active multidrug resistance reversal agents in cancer

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Modulation of multidrug resistance in tumor cells by taxinine derivatives.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

14β-Hydroxy-10-deacetylbaccatin III, a new taxane from Himalayan yew (Taxus wallichiana Zucc.)

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Flow cytometric analysis of breast cancer resistance protein expression and function.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthesis of C-ring aromatic taxoids and evaluation of their multi-drug resistance reversing activity.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthesis and evaluation of artificial taxoids with antitumor and multi-drug resistance reversing activities.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Identification of the domains of photoincorporation of the 3'- and 7-benzophenone analogues of taxol in the carboxyl-terminal half of murine mdr1b P-glycoprotein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

A New Paclitaxel Photoaffinity Analog with a 3-(4-Benzoylphenyl)propanoyl Probe for Characterization of Drug-Binding Sites on Tubulin and P-Glycoprotein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthesis and antitumor activity of novel C-7 paclitaxel ethers: discovery of BMS-184476.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Chemical modification of paclitaxel (Taxol) reduces P-glycoprotein interactions and increases permeation across the blood-brain barrier in vitro and in situ

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthesis and biological activity of macrocyclic taxane analogues

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

A common pharmacophore for cytotoxic natural products that stabilize microtubules

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Design, synthesis and biological activity of novel C2-C3' N-Linked macrocyclic taxoids

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthesis and Biological Evaluation of Novel Macrocyclic Paclitaxel Analogues

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Antitumour activity of novel taxanes that act at the same time as cytotoxic agents and P-glycoprotein inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Recent advances in tumor-targeting anticancer drug conjugates.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Semi-synthesis of an O-glycosylated docetaxel analogue

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Syntheses and Structure−Activity Relationships of Novel Nor-seco Taxoids

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthesis and Structure-Activity Relationships of Novel Nor-Seco Analogs of Taxol and Taxotere

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthesis and evaluation of C-seco paclitaxel analogues

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Antitumour and antiangiogenic effects of IDN 5390, a novel C-seco taxane, in a paclitaxel-resistant human ovarian tumour xenograft

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Structure-activity relationships of ring C-secotaxoids. 1. Acylative modifications

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Unexpectedly Facile Hydrolysis of the 2-Benzoate Group of Taxol and Syntheses of Analogs with Increased Activities

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthesis and structure-activity relationships of new second-generation taxoids

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

A Common Pharmacophore for Taxol and the Epothilones Based on the Biological Activity of a Taxane Molecule Lacking a C-13 Side Chain†

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Refined structure of alpha beta-tubulin at 3.5 A resolution

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Design and synthesis of de novo cytotoxic alkaloids through mimicking taxoid skeleton

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Phase I dose-finding study of a new taxane, RPR 109881A, administered as a one-hour intravenous infusion days 1 and 8 to patients with advanced solid tumors.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Syntheses and structure-activity relationships of taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Effects of orally active taxanes on P-glycoprotein modulation and colon and breast carcinoma drug resistance

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

The discovery of BMS-275183: an orally efficacious novel taxane

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Preclinical antitumor activity of two novel taxanes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Preclinical pharmacologic evaluation of MST-997, an orally active taxane with superior in vitro and in vivo efficacy in paclitaxel- and docetaxel-resistant tumor models

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Tubulin and microtubule structure

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Microtubule polymerization dynamics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

https://api.crossref.org/works/10.1002%2FCMDC.200600308

1 reference

7 January 2021

Promotion of microtubule assembly in vitro by taxol

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Substoichiometric binding of taxol suppresses microtubule dynamics.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

A beta-tubulin leucine cluster involved in microtubule assembly and paclitaxel resistance.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Mutations at leucine 215 of beta-tubulin affect paclitaxel sensitivity by two distinct mechanisms

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Taxol-dependent mutants of Chinese hamster ovary cells with alterations in alpha- and beta-tubulin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Do beta-tubulin mutations have a role in resistance to chemotherapy?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Microtubule structure at 8 A resolution

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

High-resolution model of the microtubule

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Intra-allelic suppression of a mutation that stabilizes microtubules and confers resistance to colcemid

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Genetic analysis of the beta-tubulin gene, TUBB, in non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Mutational analysis of the beta-tubulin gene in lung cancer

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Mutation of the class I beta-tubulin gene does not predict response to paclitaxel for breast cancer.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

No significant role for beta tubulin mutations and mismatch repair defects in ovarian cancer resistance to paclitaxel/cisplatin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

The role of beta-tubulin isotypes in resistance to antimitotic drugs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Detection of human betaV-tubulin expression in epithelial cancer cell lines by tubulin proteomics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Microtubule dynamics in vitro are regulated by the tubulin isotype composition

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

A ubiquitous beta-tubulin disrupts microtubule assembly and inhibits cell proliferation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Alterations of beta-tubulin isotypes in breast cancer cells resistant to docetaxel

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

The seco-taxane IDN5390 is able to target class III beta-tubulin and to overcome paclitaxel resistance.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Expression of class III beta-tubulin reduces microtubule assembly and confers resistance to paclitaxel

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Modulation of drug resistance by alpha-tubulin in paclitaxel-resistant human lung cancer cell lines

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Class III beta-tubulin overexpression is a marker of poor clinical outcome in advanced ovarian cancer patients.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Predictive factors for response to docetaxel in human breast cancers

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Biomarkers predictive for clinical efficacy of taxol-based chemotherapy in advanced breast cancer

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Class III beta-tubulin is a marker of paclitaxel resistance in carcinomas of unknown primary site

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Class III beta-tubulin expression in tumor cells predicts response and outcome in patients with non-small cell lung cancer receiving paclitaxel

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

The betaI/betaIII-tubulin isoforms and their complexes with antimitotic agents. Docking and molecular dynamics studies

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Spindle assembly and the art of regulating microtubule dynamics by MAPs and Stathmin/Op18.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Altered levels and regulation of stathmin in paclitaxel-resistant ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Paclitaxel resistance in cells with reduced beta-tubulin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600308

7 January 2021

Identifiers

DOI

10.1002/CMDC.200600308

1 reference

16 August 2017

1 reference