(Q36897348)

16 August 2017

1 reference

title

Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling (English)

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16 August 2017

Karl J Tronstad

6

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author name string

Hanne Hagland

1

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16 August 2017

Julie Nikolaisen

2

1 reference

16 August 2017

Linn I Hodneland

3

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16 August 2017

Bjøorn T Gjertsen

4

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16 August 2017

Øystein Bruserud

5

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16 August 2017

language of work or name

English

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publication date

1 August 2007

1 reference

Expert Opinion on Therapeutic Targets

16 August 2017

published in

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16 August 2017

volume

11

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16 August 2017

issue

8

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16 August 2017

page(s)

1055-1069

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On the Origin of Cancer Cells

16 August 2017

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Energy metabolism in tumor cells

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Akt-dependent transformation: there is more to growth than just surviving

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Akt stimulates aerobic glycolysis in cancer cells

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Increased cellular hypoxia and reduced proliferation of both normal and leukaemic cells during progression of acute myeloid leukaemia in rats.

21 January 2018

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ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage

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Mitochondrial-targeted fatty acid analog induces apoptosis with selective loss of mitochondrial glutathione in promyelocytic leukemia cells

21 January 2018

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Oxidative stress and cancer: have we moved forward?

21 January 2018

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Mitochondrial mutations in cancer

21 January 2018

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Mitochondrial DNA mutations in human cancer

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Mitochondrial tumour suppressors: a genetic and biochemical update

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Mitochondria as therapeutic targets for cancer chemotherapy

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Mitochondrial hexokinases: guardians of the mitochondria

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Apoptosis-based therapies for hematologic malignancies

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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

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Bcl-2 inhibition of autophagy: a new route to cancer?

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Autophagy as a regulated pathway of cellular degradation

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Role of autophagy in cancer: management of metabolic stress

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

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Uth1p: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death

21 January 2018

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Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival

21 January 2018

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Uth1p is involved in the autophagic degradation of mitochondria

21 January 2018

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Macroautophagy versus mitochondrial autophagy: a question of fate?

21 January 2018

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Mitochondrial-nuclear communications

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Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleus

21 January 2018

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Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis

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Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

21 January 2018

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Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions

21 January 2018

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Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose

21 January 2018

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Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

21 January 2018

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Mitochondrial bound hexokinase activity as a preventive antioxidant defense: steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria.

21 January 2018

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Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer.

21 January 2018

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Fuel feeds function: energy metabolism and the T-cell response

21 January 2018

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ATP citrate lyase is an important component of cell growth and transformation

21 January 2018

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Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

21 January 2018

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A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

21 January 2018

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The Akt-mTOR tango and its relevance to cancer

21 January 2018

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Mammalian target of rapamycin inhibition as therapy for hematologic malignancies

21 January 2018

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ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors

21 January 2018

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The coordinate regulation of the p53 and mTOR pathways in cells

21 January 2018

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FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

21 January 2018

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Nutrient sensor links obesity with diabetes risk

21 January 2018

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Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.

21 January 2018

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AMPK and cell proliferation--AMPK as a therapeutic target for atherosclerosis and cancer

21 January 2018

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LKB1-dependent signaling pathways

21 January 2018

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 January 2018

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Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer

21 January 2018

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Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators

21 January 2018

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Targeting HIF-1 for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling

21 January 2018

1 reference

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Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

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MDM2 inhibitors for cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

p53 regulates mitochondrial respiration

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Monoubiquitylation promotes mitochondrial p53 translocation

21 January 2018

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Mitochondrially targeted p53 has tumor suppressor activities in vivo

21 January 2018

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WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

21 January 2018

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

21 January 2018

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Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

21 January 2018

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Peroxisome proliferator-activated receptors: insight into multiple cellular functions

21 January 2018

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Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans?

21 January 2018

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Modified fatty acids and their possible therapeutic targets in malignant diseases

21 January 2018

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Peroxisome proliferator-activated receptor gamma in malignant diseases.

21 January 2018

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Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model

21 January 2018

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Mitochondriotoxic compounds for cancer therapy

21 January 2018

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c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

21 January 2018

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Mitochondria and cancer: is there a morphological connection?

21 January 2018

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AMP-activated protein kinase as a drug target.

21 January 2018

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The many faces of PPARgamma

21 January 2018

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The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation

21 January 2018

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Protein lysine acetylation in normal and leukaemic haematopoiesis: HDACs as possible therapeutic targets in adult AML.

21 January 2018

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Histone deacetylase inhibitors synergize p300 autoacetylation that regulates its transactivation activity and complex formation

21 January 2018

1 reference

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Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy

21 January 2018

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The Akt/PKB pathway: molecular target for cancer drug discovery

21 January 2018

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Clinical implications of neuroendocrine differentiation in prostate cancer

21 January 2018

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Proapoptotic activity of cell-permeable anti-Akt single-chain antibodies

21 January 2018

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Chemically targeting the PI3K family

21 January 2018

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mTOR and cancer: reason for dancing at the crossroads?

21 January 2018

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Inhibitors of the mammalian target of rapamycin

21 January 2018

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Future directions in the treatment of hormone-sensitive advanced breast cancer: the RAD001 (Everolimus)-letrozole clinical program

21 January 2018

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 January 2018

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Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Mitochondria: a target for cancer therapy

21 January 2018

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Arsenic trioxide and neuroblastoma cytotoxicity.

21 January 2018

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Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism

21 January 2018

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Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins.

21 January 2018

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Paclitaxel affects cytosolic calcium signals by opening the mitochondrial permeability transition pore

21 January 2018

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Antisense and nonantisense effects of antisense Bcl-2 on multiple roles of Bcl-2 as a chemosensitizer in cancer therapy

21 January 2018

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Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X(L).

21 January 2018

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Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

21 January 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437.

21 January 2018

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Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells

21 January 2018

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The AMP-activated protein kinase pathway--new players upstream and downstream.

21 January 2018

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The AMP-activated protein kinase cascade--a unifying system for energy control

21 January 2018

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The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Metabolic catastrophe as a means to cancer cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Peroxisome-proliferator-activated receptors and cancers: complex stories

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Coping with stress: multiple ways to activate p53.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Quantitative Proteomic Comparison of Rat Mitochondria from Muscle, Heart, and Liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1055

10.1517/14728222.11.8.1055

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference