(Q36897356)

16 August 2017

1 reference

title

Small-molecule modulators of Hh and Wnt signaling pathways (English)

1 reference

16 August 2017

Alex S Kiselyov

1

1 reference

16 August 2017

Sergey E Tkachenko

series ordinal

2

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16 August 2017

Konstantin V Balakin

series ordinal

3

1 reference

16 August 2017

Alexandre V Ivachtchenko

series ordinal

4

1 reference

16 August 2017

language of work or name

English

0 references

publication date

1 August 2007

1 reference

Expert Opinion on Therapeutic Targets

16 August 2017

1 reference

16 August 2017

11

1 reference

16 August 2017

8

1 reference

16 August 2017

1087-1101

1 reference

The Hedgehog and Wnt signalling pathways in cancer

16 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

A genetic screen in Drosophila for identifying novel components of the hedgehog signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Tissue repair and stem cell renewal in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Hedgehog signaling in animal development: paradigms and principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

The role of hedgehog signalling in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Activating Smoothened mutations in sporadic basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

The Wnt signaling pathway in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Wnt signalling in stem cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Wnt/beta-catenin signaling in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Developmental roles and clinical significance of hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

New players and puzzles in the Hedgehog signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Transducing the hedgehog signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Biochemical evidence that patched is the Hedgehog receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Patched acts catalytically to suppress the activity of Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Regulation of Hedgehog signaling: a complex story

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Suppressor of fused regulates Gli activity through a dual binding mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Gli and hedgehog in cancer: tumours, embryos and stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Cholesterol modification of hedgehog signaling proteins in animal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Identification of a palmitic acid-modified form of human Sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Megalin functions as an endocytic sonic hedgehog receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Hedgehog signaling: new targets for GPCRs coupled to cAMP and protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Wnts as ligands: processing, secretion and reception

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

An LDL-receptor-related protein mediates Wnt signalling in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

A new member of the frizzled family from Drosophila functions as a Wingless receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Linking colorectal cancer to Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Mechanisms of Wnt signaling in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Functional interaction of beta-catenin with the transcription factor LEF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Glycogen synthase kinase 3: a drug target for CNS therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

GSK3 inhibitors: development and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Teratogen-mediated inhibition of target tissue response to Shh signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Small molecule modulation of Smoothened activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Myc and Mad bHLHZ domains possess identical DNA-binding specificities but only partially overlapping functions in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Mining the Wnt pathway for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Novel etodolac analog SDX-308 (CEP-18082) induces cytotoxicity in multiple myeloma cells associated with inhibition of beta-catenin/TCF pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

A small-molecule agonist of the Wnt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Dishevelled-1 regulates microtubule stability: a new function mediated by glycogen synthase kinase-3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Identification of a specific inhibitor of the dishevelled PDZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

A chemical and genetic approach to the mode of action of fumagillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

A noncanonical path to mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Mechanism-based target identification and drug discovery in cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Wnt proteins are lipid-modified and can act as stem cell growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

Inhibition of protein-protein interactions: The discovery of druglike β-catenin inhibitors by combining virtual and biophysical screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1087

10.1517/14728222.11.8.1087

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference