(Q36917461)

17 August 2017

1 reference

title

Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1. (English)

1 reference

polycystic kidney disease

17 August 2017

0 references

1 reference

Thomas Weimbs

1

1 reference

17 August 2017

publication date

22 August 2007

1 reference

American Journal of Physiology - Renal Physiology

17 August 2017

published in

1 reference

17 August 2017

volume

293

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17 August 2017

issue

5

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17 August 2017

page(s)

F1423-32

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Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors

17 August 2017

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1 reference

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Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2

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PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

21 January 2018

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21 January 2018

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Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells

21 January 2018

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Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy.

21 January 2018

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Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure

21 January 2018

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Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene

21 January 2018

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Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease--a contiguous gene syndrome

21 January 2018

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Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat.

21 January 2018

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More than colocalizing with polycystin-1, polycystin-L is in the centrosome

21 January 2018

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Persistent renal and extrarenal immune changes after severe ischemic injury

21 January 2018

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Role of matrix metalloproteinases in renal pathophysiologies

21 January 2018

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Autosomal dominant polycystic kidney disease: time for a change?

21 January 2018

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Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

21 January 2018

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Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy

21 January 2018

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VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells

21 January 2018

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Galectin-3 associates with the primary cilium and modulates cyst growth in congenital polycystic kidney disease

21 January 2018

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Positional cloning of jcpk/bpk locus of the mouse

21 January 2018

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Update on mechanisms of ischemic acute kidney injury

21 January 2018

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Defective planar cell polarity in polycystic kidney disease

21 January 2018

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Progressive segregation of unmyelinated axons in peripheral nerves, myelin alterations in the CNS, and cyst formation in the kidneys of myelin and lymphocyte protein-overexpressing mice

21 January 2018

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The versatile nature of the calcium-permeable cation channel TRPP2

21 January 2018

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Characteristics of glomerulotubular balance

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Understanding pathogenic mechanisms in polycystic kidney disease provides clues for therapy

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Signaling mechanisms, interaction partners, and target genes of STAT6.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Tuberous sclerosis and the kidney: from mesenchyme to epithelium, and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Urinary clusterin levels in the rat correlate with the severity of tubular damage and may help to differentiate between glomerular and tubular injuries

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

An interleukin-4-induced transcription factor: IL-4 Stat

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Genetics and pathogenesis of polycystic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Dysregulation of the TSC-mTOR pathway in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Interleukin 13 gene transfer in liver ischemia and reperfusion injury: role of Stat6 and TLR4 pathways in cytoprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Interaction between RGS7 and polycystin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

The polycystic kidney disease 1 gene product modulates Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Siah-1 interacts with the intracellular region of polycystin-1 and affects its stability via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin 1 is required for the structural integrity of blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Membrane trafficking of angiotensin receptor type-1 and mechanochemical signal transduction in proximal tubule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Kidney injury molecule-1 expression in murine polycystic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Got RIP? Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

TSC2: filling the GAP in the mTOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Annexin A5 interacts with polycystin-1 and interferes with the polycystin-1 stimulated recruitment of E-cadherin into adherens junctions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

MAL regulates clathrin-mediated endocytosis at the apical surface of Madin-Darby canine kidney cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Sirolimus Prolongs Recovery from Delayed Graft Function After Cadaveric Renal Transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Up-regulation of galectin-3 in acute renal failure of the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

A possible role for metalloproteinases in renal cyst development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Molecular pathogenesis of ADPKD: the polycystin complex gets complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Tuberous sclerosis complex: from Drosophila to human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

C-type lectin-like domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Bending the MDCK cell primary cilium increases intracellular calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Removal of the MDCK cell primary cilium abolishes flow sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

The renal cell primary cilium functions as a flow sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

PKD1 interacts with PKD2 through a probable coiled-coil domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

"Mistakes happen": somatic mutation and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Role of immunocompetent cells in nonimmune renal diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Renal cystic disease in tuberous sclerosis: role of the polycystic kidney disease 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystic kidney disease: cell division without a c(l)ue?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Addition of sirolimus to cyclosporine delays the recovery from delayed graft function but does not affect 1-year graft function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin-1 can interact with homer 1/Vesl-1 in postnatal hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Overexpression of PKD1 causes polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystic kidney disease: genes, proteins, animal models, disease mechanisms and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Autosomal dominant polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Xenopus Bicaudal-C is required for the differentiation of the amphibian pronephros.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Characterization of cis-autoproteolysis of polycystin-1, the product of human polycystic kidney disease 1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Regulation of mTOR by polycystin-1: is polycystic kidney disease a case of futile repair?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Identification and expression of the mammalian homologue of Bicaudal-C

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

The polycystin-1 C-type lectin domain binds carbohydrate in a calcium-dependent manner, and interacts with extracellular matrix proteins in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Polycystin-1 interacts with intermediate filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Role of primary cilia in the pathogenesis of polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Molecular pathogenesis of autosomal dominant polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

IL-13 activates STAT6 and inhibits liver injury induced by ischemia/reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

T cells as mediators in renal ischemia/reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

The C-terminal tail of the polycystin-1 protein interacts with the Na,K-ATPase alpha-subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

Cystic kidney diseases: all roads lead to the cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00275.2007

10.1152/AJPRENAL.00275.2007

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference