(Q36947975)

English

Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) Ligands

scientific article published on 05 May 2016

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scholarly article

1 reference

Europe PubMed Central

17 August 2017

Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) Ligands (English)

1 reference

Europe PubMed Central

17 August 2017

Aubrie A Harland

object named as

Aubrie A Harland

1

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author name string

Aaron M Bender

2

1 reference

Europe PubMed Central

17 August 2017

Nicholas W Griggs

3

1 reference

Europe PubMed Central

17 August 2017

Chao Gao

4

1 reference

Europe PubMed Central

17 August 2017

Jessica P Anand

5

1 reference

Europe PubMed Central

17 August 2017

Irina D Pogozheva

6

1 reference

Europe PubMed Central

17 August 2017

John R Traynor

7

1 reference

Europe PubMed Central

17 August 2017

Emily M Jutkiewicz

8

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Europe PubMed Central

17 August 2017

Henry I Mosberg

9

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Europe PubMed Central

17 August 2017

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publication date

5 May 2016

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Europe PubMed Central

17 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

17 August 2017

59

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Europe PubMed Central

17 August 2017

10

1 reference

Europe PubMed Central

17 August 2017

4985-4998

1 reference

Europe PubMed Central

17 August 2017

Further Optimization and Evaluation of Bioavailable, Mixed-Efficacy μ-Opioid Receptor (MOR) Agonists/δ-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Structural insights into µ-opioid receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Asymmetric synthesis and in vitro and in vivo activity of tetrahydroquinolines featuring a diverse set of polar substitutions at the 6 position as mixed-efficacy μ opioid receptor/δ opioid receptor ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers

1 reference

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29 September 2017

Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Molecular control of δ-opioid receptor signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Eluxadoline benefits patients with irritable bowel syndrome with diarrhea in a phase 2 study

1 reference

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29 September 2017

Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models

1 reference

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Structure of the human κ-opioid receptor in complex with JDTic

1 reference

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29 September 2017

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

μ-Opioid receptor coupling to Gα(o) plays an important role in opioid antinociception

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Bi- or multifunctional opioid peptide drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Multi-target-directed ligands to combat neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Reversal of diastereofacial selectivity in hydride reductions of N-tert-butanesulfinyl imines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Homology modeling of opioid receptor-ligand complexes using experimental constraints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Designed multiple ligands. An emerging drug discovery paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

BU74, a complex oripavine derivative with potent kappa opioid receptor agonism and delayed opioid antagonism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

29 September 2017

Differential binding properties of oripavines at cloned mu- and delta-opioid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

27 June 2018

Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

27 June 2018

Modulation of the potency and efficacy of mu-mediated antinociception by delta agonists in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885601

27 June 2018

One-pot asymmetric synthesis of either diastereomer of tert-butanesulfinyl-protected amines from ketones

1 reference

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4 September 2018

Complex of an active mu-opioid receptor with a cyclic peptide agonist modeled from experimental constraints

1 reference

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4 September 2018

Attenuation of morphine tolerance and dependence with the highly selective delta-opioid receptor antagonist TIPP[psi].

1 reference

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1 reference

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1 reference

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12 December 2020

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Identifiers

10.1021/ACS.JMEDCHEM.6B00308

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

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