(Q36960492)

English

Cellular uptake and intracellular release are major obstacles to the therapeutic application of siRNA: novel options by phosphorothioate-stimulated delivery

scientific article published on October 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

1 reference

Europe PubMed Central

Cellular uptake and intracellular release are major obstacles to the therapeutic application of siRNA: novel options by phosphorothioate-stimulated delivery (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

author name string

Alessandra Mescalchin

1

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Anke Detzer

2

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Maria Wecke

3

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Marita Overhoff

4

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Winfried Wünsche

5

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Georg Sczakiel

6

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

language of work or name

0 references

publication date

1 October 2007

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Expert Opinion on Biological Therapy

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Europe PubMed Central

PubMed publication ID

17 August 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

1531-1538

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Illuminating the silence: understanding the structure and function of small RNAs

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RNA interference

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Ribo-gnome: the big world of small RNAs

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RNAi: the nuts and bolts of the RISC machine

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ATP modulates siRNA interactions with an endogenous human Dicer complex

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ATP requirements and small interfering RNA structure in the RNA interference pathway

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Lentiviral-mediated delivery of siRNAs for antiviral therapy

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Approaches for chemically synthesized siRNA and vector-mediated RNAi

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RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

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Tuning silence: conditional systems for RNA interference

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Expressing short hairpin RNAs in vivo

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shRNA libraries and their use in cancer genetics

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Therapeutic short hairpin RNA expression in the liver: viral targets and vectors

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Unlocking the potential of the human genome with RNA interference

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Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting

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The silent treatment: siRNAs as small molecule drugs

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RNAi therapeutics: a potential new class of pharmaceutical drugs

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A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium

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Delivery of RNA interference

1 reference

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siRNAs: applications in functional genomics and potential as therapeutics

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Strategies for silencing human disease using RNA interference

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Ligand-targeted delivery of therapeutic siRNA.

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RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

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21 January 2018

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo

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Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

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21 January 2018

The therapeutic potential of RNA interference

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Nucleic-acid therapeutics: basic principles and recent applications

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Non-viral gene delivery: from the needle to the nucleus

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Programmed drug delivery: nanosystems for tumor targeting

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Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: quantitative analysis of uptake and biological effect

1 reference

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Phosphorothioate-stimulated uptake of short interfering RNA by human cells

1 reference

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21 January 2018

Regulated portals of entry into the cell

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siRNA in human cells selectively localizes to target RNA sites

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Assembly and trafficking of caveolar domains in the cell: caveolae as stable, cargo-triggered, vesicular transporters

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Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms

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Defining and assaying RNAi in mammalian cells

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Transfection of "naked" siRNA results in endosomal uptake and metabolic impairment in cultured neurons

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Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells.

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Efficient delivery of RNA interference effectors via in vitro-packaged SV40 pseudovirions

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A bi-functional siRNA construct induces RNA interference and also primes PCR amplification for its own quantification

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Quantitative detection of siRNA and single-stranded oligonucleotides: relationship between uptake and biological activity of siRNA.

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Analysis of gene function in somatic mammalian cells using small interfering RNAs

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum

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Caveolar endocytosis of simian virus 40 is followed by brefeldin A-sensitive transport to the endoplasmic reticulum, where the virus disassembles

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Specific and potent RNAi in the nucleus of human cells

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Identification and partial purification of human double strand RNase activity. A novel terminating mechanism for oligoribonucleotide antisense drugs

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The subcellular localization and length of hammerhead ribozymes determine efficacy in human cells

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Regulation of NF-kappaB signaling by decoy oligodeoxynucleotides

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Visualizing a Correlation between siRNA Localization, Cellular Uptake, and RNAi in Living Cells

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Caveolin-Stabilized Membrane Domains as Multifunctional Transport and Sorting Devices in Endocytic Membrane Traffic

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Identifiers

10.1517/14712598.7.10.1531

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

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