(Q36975842)

17 August 2017

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title

Processing of nonconventional DNA strand break ends (English)

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17 August 2017

David M Wilson

1

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17 August 2017

1 December 2007

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Environmental and Molecular Mutagenesis

17 August 2017

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17 August 2017

48

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17 August 2017

9

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17 August 2017

772-782

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Incorporated bromodeoxyuridine enhances the sister-chromatid exchange and chromosomal aberration frequencies in an EMS-sensitive Chinese hamster cell line

17 August 2017

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Induction of chromosomal aberrations in the CHO mutant EM9 and its parental line AA8 by EcoRI restriction endonuclease: electroporation experiments

21 January 2018

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Pathways for mitotic homologous recombination in mammalian cells

21 January 2018

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DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes

21 January 2018

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XRCC1 keeps DNA from getting stranded

21 January 2018

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Molecular mechanisms of sister-chromatid exchange

21 January 2018

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The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

21 January 2018

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7 January 2021

Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

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7 January 2021

Studies on chromosome aberration induction: what can they tell us about DNA repair?

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7 January 2021

Exonucleolytic proofreading by p53 protein

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7 January 2021

5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro

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7 January 2021

DNA strand breaks produced by oxidative stress in mammalian cells exhibit 3'-phosphoglycolate termini.

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7 January 2021

XRCC1 is required for DNA single-strand break repair in human cells

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7 January 2021

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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7 January 2021

Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs

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7 January 2021

Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate.

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7 January 2021

Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining

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7 January 2021

An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA

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7 January 2021

A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA.

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7 January 2021

Repair of DNA covalently linked to protein.

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7 January 2021

Acid DNases and their interest among apoptotic endonucleases

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7 January 2021

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

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7 January 2021

Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone

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7 January 2021

Repair of oxidative damage to DNA: enzymology and biology

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7 January 2021

Multiple endonucleases function to repair covalent topoisomerase I complexes in Saccharomyces cerevisiae

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7 January 2021

Free radical-induced damage to DNA: mechanisms and measurement

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7 January 2021

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

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7 January 2021

XRCC1 co-localizes and physically interacts with PCNA

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7 January 2021

XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells.

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7 January 2021

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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7 January 2021

Nucleoside analogues and nucleobases in cancer treatment.

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7 January 2021

Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair

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7 January 2021

Deoxyribophosphate lyase activity of mammalian endonuclease VIII-like proteins.

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7 January 2021

Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae

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7 January 2021

Requirement of yeast Rad1-Rad10 nuclease for the removal of 3'-blocked termini from DNA strand breaks induced by reactive oxygen species

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7 January 2021

The DNA 3′‐phosphatase and 5′‐hydroxyl kinase of rat liver chromatin

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7 January 2021

Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III.

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7 January 2021

A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair

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7 January 2021

The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta

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7 January 2021

WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups

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7 January 2021

DNA double-strand break repair: from mechanistic understanding to cancer treatment

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7 January 2021

Genome maintenance mechanisms for preventing cancer

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7 January 2021

A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein

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7 January 2021

Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein

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7 January 2021

Characterization of the human and mouse WRN 3'-->5' exonuclease

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7 January 2021

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

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7 January 2021

Resistance of 3'-phosphoglycolate DNA ends to digestion by mammalian DNase III.

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7 January 2021

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

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7 January 2021

Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage

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7 January 2021

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

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7 January 2021

Repair of DNA strand gaps and nicks containing 3'-phosphate and 5'-hydroxyl termini by purified mammalian enzymes

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7 January 2021

Molecular characterization of a human DNA kinase

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7 January 2021

The role of yeast DNA 3'-phosphatase Tpp1 and rad1/Rad10 endonuclease in processing spontaneous and induced base lesions

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7 January 2021

Single-stranded breaks in DNA but not oxidative DNA base damages block transcriptional elongation by RNA polymerase II in HeLa cell nuclear extracts.

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7 January 2021

Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation

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7 January 2021

Cross-linking of 2-deoxyribonolactone and its beta-elimination product by base excision repair enzymes

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7 January 2021

Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (

1 reference

7 January 2021

Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides.

1 reference

7 January 2021

The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities

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7 January 2021

A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus

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7 January 2021

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

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7 January 2021

Instability and decay of the primary structure of DNA

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7 January 2021

Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.

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7 January 2021

Template strand gap bypass is a general property of prokaryotic RNA polymerases: implications for elongation mechanisms.

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7 January 2021

Flap endonuclease 1: a central component of DNA metabolism

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7 January 2021

Transcription - guarding the genome by sensing DNA damage

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7 January 2021

Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

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7 January 2021

Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases

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7 January 2021

A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents

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7 January 2021

Cellular response to etoposide treatment.

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7 January 2021

Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner

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7 January 2021

Evidence that camptothecin-induced aberrations in the G2 phase of cell cycle of Chinese hamster ovary (CHO) cell lines is associated with transcription

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7 January 2021

Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

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7 January 2021

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

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7 January 2021

Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage

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7 January 2021

Translocation of XRCC1 and DNA ligase IIIalpha from centrosomes to chromosomes in response to DNA damage in mitotic human cells

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7 January 2021

Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins

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7 January 2021

APE1-dependent repair of DNA single-strand breaks containing 3'-end 8-oxoguanine

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7 January 2021

APE1 is the major 3'-phosphoglycolate activity in human cell extracts

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7 January 2021

DNA polymerase delta-dependent repair of DNA single strand breaks containing 3'-end proximal lesions

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7 January 2021

Exonucleases and the incorporation of aranucleotides into DNA.

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7 January 2021

3′-Phosphatase activity of the DNA kinase from rat liver

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7 January 2021

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes

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7 January 2021

Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks

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7 January 2021

Processing of 3'-phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease

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7 January 2021

Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents

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7 January 2021

C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

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7 January 2021

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks

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7 January 2021

RNA polymerase encounters with DNA damage: transcription-coupled repair or transcriptional mutagenesis?

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7 January 2021

The 3' 5' exonucleases

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7 January 2021

Substrate specificity of the p53-associated 3'-5' exonuclease

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7 January 2021

The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity

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7 January 2021

A mechanistic perspective on the chemistry of DNA repair glycosylases

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7 January 2021

Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta

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7 January 2021

3'-phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends

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7 January 2021

Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends

1 reference

7 January 2021

Pathways to motor incoordination: the inherited ataxias

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7 January 2021

A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair

1 reference

7 January 2021

Polynucleotide Kinase from Rat-Liver Nuclei. Purification and Properties

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7 January 2021

Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatases

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7 January 2021

Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage

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7 January 2021

XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions

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7 January 2021

Cellular roles of dna topoisomerases: a molecular perspective

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7 January 2021

DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability

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7 January 2021

Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination

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7 January 2021

XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair

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7 January 2021

AP endonuclease-independent DNA base excision repair in human cells

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7 January 2021

Properties of and substrate determinants for the exonuclease activity of human apurinic endonuclease Ape1.

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7 January 2021

Neurodegeneration: nicked to death

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7 January 2021

Mammalian base excision repair and DNA polymerase beta

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7 January 2021

Human HeLa cell enzymes that remove phosphoglycolate 3'-end groups from DNA

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7 January 2021

Removal of 3'-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1

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7 January 2021

Environmental and chemical carcinogenesis

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7 January 2021

DNA double-strand break repair: all's well that ends well

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7 January 2021

Effects of abasic sites and DNA single-strand breaks on prokaryotic RNA polymerases

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7 January 2021

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

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7 January 2021

Identifiers

DOI

10.1002/EM.20346

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17 August 2017

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PubMed ID

17948279