(Q36991032)

17 August 2017

Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes (English)

1 reference

17 August 2017

Richard Chahwan

2

0 references

Sergio Roa

object named as

Sergio Roa

4

0 references

Thomas A Kunkel

object named as

Thomas A Kunkel

9

0 references

Matthew D Scharff

10

object named as

Matthew D Scharff

1 reference

17 August 2017

Sonja Schaetzlein

1

1 reference

17 August 2017

Elena Avdievich

3

1 reference

17 August 2017

Kaichun Wei

5

1 reference

17 August 2017

Robert L Eoff

6

1 reference

17 August 2017

Rani S Sellers

7

1 reference

17 August 2017

Alan B Clark

8

1 reference

17 August 2017

Winfried Edelmann

11

1 reference

17 August 2017

language of work or name

English

0 references

publication date

10 June 2013

1 reference

Proceedings of the National Academy of Sciences of the United States of America

17 August 2017

1 reference

17 August 2017

110

1 reference

17 August 2017

27

1 reference

17 August 2017

E2470-9

1 reference

describes a project that uses

17 August 2017

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/3704034

inferred from PubMed Central ID database lookup

cites work

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Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents

29 September 2017

1 reference

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Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.

29 September 2017

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Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

29 September 2017

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Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

29 September 2017

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BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

29 September 2017

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Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions

29 September 2017

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29 September 2017

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29 September 2017

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PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance

29 September 2017

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A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair

29 September 2017

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Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents

29 September 2017

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MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites

29 September 2017

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29 September 2017

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Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry

29 September 2017

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Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA

29 September 2017

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The DNA-damage response in human biology and disease

29 September 2017

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Mechanisms of double-strand break repair in somatic mammalian cells

29 September 2017

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Comprehensive molecular analysis of mismatch repair gene defects in suspected Lynch syndrome (hereditary nonpolyposis colorectal cancer) cases

29 September 2017

1 reference

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DNA end resection: many nucleases make light work

29 September 2017

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A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair

29 September 2017

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29 September 2017

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Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

29 September 2017

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Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

29 September 2017

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Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

29 September 2017

1 reference

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Structural and functional relationships of the XPF/MUS81 family of proteins

29 September 2017

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A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiae

29 September 2017

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The biochemistry of somatic hypermutation

29 September 2017

1 reference

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Comparative analysis of meiotic progression in female mice bearing mutations in genes of the DNA mismatch repair pathway

29 September 2017

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Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice

29 September 2017

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A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.

29 September 2017

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Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2

29 September 2017

1 reference

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Mechanisms in eukaryotic mismatch repair

29 September 2017

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DNA mismatch repair: functions and mechanisms

29 September 2017

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Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse

29 September 2017

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Circular binary segmentation for the analysis of array-based DNA copy number data

29 September 2017

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Analysis of array CGH data: from signal ratio to gain and loss of DNA regions

29 September 2017

1 reference

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Is hEXO1 a cancer predisposing gene?

29 September 2017

1 reference

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Mismatch repair and DNA damage signalling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Role of DNA mismatch repair defects in the pathogenesis of human cancer

29 September 2017

1 reference

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Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Meiotic arrest and aneuploidy in MLH3-deficient mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Human exonuclease I is required for 5' and 3' mismatch repair

29 September 2017

1 reference

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Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism

29 September 2017

1 reference

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The selection for mismatch repair defects in hereditary nonpolyposis colorectal cancer: revising the mutator hypothesis.

29 September 2017

1 reference

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exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Decreased meiotic intergenic recombination and increased meiosis I nondisjunction in exo1 mutants of Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Human exonuclease I interacts with the mismatch repair protein hMSH2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Female embryonic lethality in mice nullizygous for both Msh2 and p53

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Meiotic pachytene arrest in MLH1-deficient mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Tumor spectrum analysis in p53-mutant mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

A DNA exonuclease induced during meiosis of Schizosaccharomyces pombe.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Separable roles for Exonuclease I in meiotic DNA double-strand break repair.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

The associated contributions of p53 and the DNA mismatch repair protein Msh6 to spontaneous tumorigenesis.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Mechanisms of tolerance to DNA damaging therapeutic drugs

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Structure of the human MLH1 locus and analysis of a large hereditary nonpolyposis colorectal carcinoma kindred for mlh1 mutations.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

The use of shuttle vectors for mutation analysis in transgenic mice and rats.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704034

Genetic analysis of the mouse brain proteome

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1308512110

Genomic instability and apoptosis are frequent in p53 deficient young mice

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23754438

12 December 2020

inferred from PubMed ID database lookup

Construction of MMR plasmid substrates and analysis of MMR error correction and excision

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23754438

12 December 2020

inferred from PubMed ID database lookup

A role for Mlh3 in somatic hypermutation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23754438

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1308512110

1 reference

17 August 2017

0 references

1 reference

17 August 2017

PubMed publication ID

23754438

1 reference