(Q37004729)

17 August 2017

1 reference

title

The parkin protein as a therapeutic target in Parkinson's disease (English)

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17 August 2017

1 reference

Konstanze F Winklhofer

series ordinal

1

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language of work or name

English

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publication date

1 December 2007

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Expert Opinion on Therapeutic Targets

17 August 2017

1 reference

17 August 2017

11

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17 August 2017

12

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17 August 2017

1543-1552

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Alpha-synuclein in Lewy bodies

17 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Stages in the development of Parkinson's disease-related pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Toxin-induced models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Genetic mouse models of parkinsonism: strengths and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Parkinson's disease: a rethink of rodent models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Parkin genetics: one model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Genetics of parkin-linked disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

How much phenotypic variation can be attributed to parkin genotype?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Lewy bodies and parkinsonism in families with parkin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

G2019S LRRK2 mutation causing Parkinson's disease without Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Biochemical and pathological characterization of Lrrk2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Drosophila models pioneer a new approach to drug discovery for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Polyubiquitin chains: polymeric protein signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Modification of proteins by ubiquitin and ubiquitin-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Parkin: a multifaceted ubiquitin ligase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Identification of far upstream element-binding protein-1 as an authentic Parkin substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Impaired transcriptional upregulation of Parkin promoter variant under oxidative stress and proteasomal inhibition: clinical association

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Ubiquitin signalling in the NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Ubiquitylation and cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

DJ-1 and Parkin Modulate Dopamine-dependent Behavior and Inhibit MPTP-induced Nigral Dopamine Neuron Loss in Mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Neuronal specificity of alpha-synuclein toxicity and effect of Parkin co-expression in primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Pathogenic mutations inactivate parkin by distinct mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Dopamine covalently modifies and functionally inactivates parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

The C289G and C418R missense mutations cause rapid sequestration of human Parkin into insoluble aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

RING finger 1 mutations in Parkin produce altered localization of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Differential effects of Parkin and its mutants on protein aggregation, the ubiquitin-proteasome system, and neuronal cell death in human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Neuroprotective effect of vitamin E on the early model of Parkinson's disease in rat: behavioral and histochemical evidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Activators and target genes of Rel/NF-kappaB transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

21 January 2018

Signaling to NF-kappaB

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Analysis of alpha-synuclein, dopamine and parkin pathways in neuropathologically confirmed parkinsonian nigra.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

NF-kappa B as a therapeutic target in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Physiological functions for brain NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Linking JNK signaling to NF-kappaB: a key to survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Signal transduction by the JNK group of MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

The role of c-Jun N-terminal kinase (JNK) in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Neurodegenerative and physiological actions of c-Jun N-terminal kinases in the mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1543

10.1517/14728222.11.12.1543

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference

PubMed ID

18020977