(Q37008841)

17 August 2017

1 reference

title

Expanding the repertoire of RNA interference screens for developing new anticancer drug targets (English)

1 reference

17 August 2017

1 reference

Steven A Haney

1

1 reference

PubMed ID

18028008

17 August 2017

language of work or name

English

0 references

publication date

1 November 2007

1 reference

Expert Opinion on Therapeutic Targets

17 August 2017

1 reference

17 August 2017

11

1 reference

17 August 2017

11

1 reference

17 August 2017

1429-1441

1 reference

High-throughput RNAi screening in cultured cells: a user's guide.

17 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Building mammalian signalling pathways with RNAi screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Oncology studies using siRNA libraries: the dawn of RNAi-based genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

shRNA libraries and their use in cancer genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Delivery of RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Increasing the robustness and validity of RNAi screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

What are the reasons for negative phase III trials of molecular-target-based drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Anticancer drug development incorporating high-content screening and RNAi: synergistic approaches to improve target identification and validation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

High-content screening moves to the front of the line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

High-content screening with siRNA optimizes a cell biological approach to drug discovery: defining the role of P53 activation in the cellular response to anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

High-content screening and profiling of drug activity in an automated centrosome-duplication assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

High-content profiling of drug-drug interactions: cellular targets involved in the modulation of microtubule drug action by the antifungal ketoconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Analysis of cell-based RNAi screens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Defining and assaying RNAi in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Lessons from phase III clinical trials on anti-VEGF therapy for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Drug-like properties and the causes of poor solubility and poor permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Detection and classification of threat agents via high-content assays of mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Inflammatory pathway analysis using a high content screening platform

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Ligand-selective signaling and high-content screening for GPCR drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Multidimensional drug profiling by automated microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Genome-scale loss-of-function screening with a lentiviral RNAi library

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

RNAi and HTS: exploring cancer by systematic loss-of-function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Quantitative morphological signatures define local signaling networks regulating cell morphology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Why is cancer drug discovery so difficult?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

New approaches in systemic treatment of advanced colorectal cancer: the molecular targets era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Interpreting clinical trials in lung cancer: impact of methodology and endpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Rethinking clinical trials for cytostatic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

New science-based endpoints to accelerate oncology drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Drug development in oncology: classical cytotoxics and molecularly targeted agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Clinical cardiac tolerability of trastuzumab

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Putting the brakes on cylindromatosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

A resource for large-scale RNA-interference-based screens in mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

A functional approach to questions about life, death, and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Cellular imaging in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Synthetic lethal screen identification of chemosensitizer loci in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Systematic genome-wide screens of gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Genome-wide RNAi analysis of growth and viability in Drosophila cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Identification of JAK/STAT signalling components by genome-wide RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Functional genomic analysis of the Wnt-wingless signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Genes required for mitotic spindle assembly in Drosophila S2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Chromosome segregation and genomic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Patterns of somatic mutation in human cancer genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Identification of pancreatic cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Stem cells in prostate cancer initiation and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Lineage dependency and lineage-survival oncogenes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Complex networks orchestrate epithelial-mesenchymal transitions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

The fallacy of epithelial mesenchymal transition in neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Exploring a new twist on tumor metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Notch signaling in development and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

A computerized cellular imaging system for high content analysis in Monastrol suppressor screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Compound classification using image-based cellular phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Stromal fibroblasts in cancer initiation and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

The role of the microenvironment and intercellular cross-talk in tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

A genetic screen for candidate tumor suppressors identifies REST

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

A loss-of-function RNA interference screen for molecular targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

A high-throughput loss-of-function screening identifies novel p53 regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

Minimizing the risk of reporting false positives in large-scale RNAi screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1429

10.1517/14728222.11.11.1429

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference

PubMed ID

18028008