(Q37030878)

17 August 2017

1 reference

title

Aurora kinase inhibitors: identification and preclinical validation of their biomarkers (English)

1 reference

17 August 2017

0 references

Patrizia Carpinelli

1

1 reference

17 August 2017

Jürgen Moll

series ordinal

2

1 reference

17 August 2017

language of work or name

English

0 references

publication date

1 January 2008

1 reference

Expert Opinion on Therapeutic Targets

17 August 2017

published in

1 reference

17 August 2017

volume

12

1 reference

17 August 2017

issue

1

1 reference

17 August 2017

page(s)

69-80

1 reference

Clinical biomarkers in drug discovery and development

17 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Biomarkers in cancer staging, prognosis and treatment selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Recent advances in biomarkers for cancer diagnosis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Validating Aurora B as an anti-cancer drug target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Mitotic kinases: the key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Chromosomal passengers and the (aurora) ABCs of mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Aurora kinases: new targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

The cellular geography of aurora kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Patterns of somatic mutation in human cancer genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Overexpression and amplification of Aurora-A in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Human TPX2 is required for targeting Aurora-A kinase to the spindle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

HEF1-dependent Aurora A activation induces disassembly of the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Live or let die: the cell's response to p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Post-translational modification of p53 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

TACC1-chTOG-Aurora A protein complex in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Searching for biomarkers of Aurora-A kinase activity: identification of in vitro substrates through a modified KESTREL approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Aurora B regulates MCAK at the mitotic centromere

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Phosphorylation by Aurora B Converts MgcRacGAP to a RhoGAP during Cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Phosphorylation of histone H3 at serine 10 is correlated with chromosome condensation during mitosis and meiosis in Tetrahymena

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histopathologic and molecular consequences of receptor inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Assessing proliferation, cell-cycle arrest and apoptotic end points in human buccal punch biopsies for use as pharmacodynamic biomarkers in drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

Plucked human hair as a tissue in which to assess pharmacodynamic end points during drug development studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.69

21 January 2018

Identifiers

DOI

10.1517/14728222.12.1.69

1 reference

17 August 2017

1 reference