(Q37122089)

18 August 2017

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title

Structure, function, and mechanism of cytosolic quinone reductases (English)

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18 August 2017

3

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18 August 2017

Mario A Bianchet

1

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author name string

Sabri Bora Erdemli

series ordinal

2

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18 August 2017

publication date

1 January 2008

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18 August 2017

published in

Vitamins and Hormones

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18 August 2017

volume

78

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18 August 2017

page(s)

63-84

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Binding of the anticancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex

18 August 2017

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The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)

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7 January 2021

Redox and addition chemistry of quinoid compounds and its biological implications

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7 January 2021

Crystal structure of quinone reductase 2 in complex with resveratrol

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7 January 2021

Mechanism of NAD(P)H:Quinone reductase: Ab initio studies of reduced flavin

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7 January 2021

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7 January 2021

DT-diaphorase protects against menadione-induced oxidative stress.

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7 January 2021

Design of highly active analogues of the pyrrolo[1,2-a]benzimidazole antitumor agents.

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7 January 2021

DT-diaphorase: a target for new anticancer drugs

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7 January 2021

Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview

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7 January 2021

RH1 induces cellular damage in an NAD(P)H:quinone oxidoreductase 1-dependent manner: relationship between DNA cross-linking, cell cycle perturbations, and apoptosis.

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7 January 2021

5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo

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7 January 2021

Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen

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7 January 2021

DT diaphorase. I. Purification from the soluble fraction of rat-liver cytoplasm, and properties

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7 January 2021

Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes

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7 January 2021

Structure-Based Development of Anticancer Drugs

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7 January 2021

Development of novel quinone phosphorodiamidate prodrugs targeted to DT-diaphorase

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7 January 2021

Crystal structure of human quinone reductase type 2, a metalloflavoprotein

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7 January 2021

The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase

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7 January 2021

Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954

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7 January 2021

Toxic effects of daunorubicin on isolated and cultured heart cells from neonatal rats

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7 January 2021

The bioreduction of a series of benzoquinone ansamycins by NAD(P)H:quinone oxidoreductase 1 to more potent heat shock protein 90 inhibitors, the hydroquinone ansamycins

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7 January 2021

Structure-function relationship of NAD(P)H:quinone reductase: characterization of NH2-terminal blocking group and essential tyrosine and lysine residues

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7 January 2021

Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones

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7 January 2021

AROMATIC AZO DERIVATIVES PREVENTING MAMMARY CANCER AND ADRENAL INJURY FROM 7,12-DIMETHYLBENZ(a)ANTHRACENE

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7 January 2021

Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles

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7 January 2021

One-electron-transfer reactions in biochemical systems. V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase)

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7 January 2021

Regulation of antioxidant response element-dependent induction of detoxifying enzyme synthesis

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7 January 2021

The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

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7 January 2021

The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction

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7 January 2021

Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice

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7 January 2021

Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual

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7 January 2021

Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs

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7 January 2021

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity

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7 January 2021

Molecular targeting of mitomycin C chemotherapy

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7 January 2021

Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development

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7 January 2021

Purification and crystallization of rat liver NAD(P)H:(quinone-acceptor) oxidoreductase by cibacron blue affinity chromatography: identification of a new and potent inhibitor

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7 January 2021

Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells

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7 January 2021

DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.

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7 January 2021

Inhibitors of topoisomerase II based on the benzodiimidazole and dipyrroloimidazobenzimidazole ring systems: controlling DT-diaphorase reductive inactivation with steric bulk

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7 January 2021

Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)

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7 January 2021

Structure of the semiquinone form of flavodoxin from Clostridum MP. Extension of 1.8 A resolution and some comparisons with the oxidized state

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7 January 2021

Vitamin K-dependent carboxylase

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7 January 2021

Regulatory network of mitomycin C action in human colon cancer cells

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7 January 2021

Protection by uridine diphosphoglucuronic acid and DT-diaphorase against the cytotoxicity of polycyclic aromatic hydrocarbons isolated from a complex coal gasification condensate

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7 January 2021

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

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7 January 2021

NRH:quinone reductase 2: an enzyme of surprises and mysteries

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7 January 2021

NAD(P)H dehydrogenase and its role in the vitamin K (2-methyl-3-phytyl-1,4-naphthaquinone)-dependent carboxylation reaction

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7 January 2021

Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches

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7 January 2021

Sigmatropic reactions of the aziridinyl semiquinone species. Why aziridinyl benzoquinones are metabolically more stable than aziridinyl indoloquinones

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7 January 2021

Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)

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7 January 2021

10.1016/S0083-6729(07)00004-0

Identifiers

DOI

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18 August 2017

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