(Q37127938)

English

Poxvirus MC160 protein utilizes multiple mechanisms to inhibit NF-kappaB activation mediated via components of the tumor necrosis factor receptor 1 signal transduction pathway.

scientific article published on 21 January 2009

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scholarly article

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20 January 2020

Poxvirus MC160 protein utilizes multiple mechanisms to inhibit NF-kappaB activation mediated via components of the tumor necrosis factor receptor 1 signal transduction pathway (English)

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20 January 2020

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Joanna L. Shisler

2

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20 January 2020

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Daniel Brian Nichols

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20 January 2020

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21 January 2009

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20 January 2020

Journal of Virology

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20 January 2020

83

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20 January 2020

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20 January 2020

3162-3174

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Europe PubMed Central

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20 January 2020

Inhibition of IkappaB kinase by vaccinia virus virulence factor B14

1 reference

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14 September 2017

Positive and negative signaling components involved in TNFalpha-induced NF-kappaB activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

14 September 2017

Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

1 reference

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14 September 2017

IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

1 reference

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14 September 2017

Poxviral regulation of the host NF-kappaB response: the vaccinia virus M2L protein inhibits induction of NF-kappaB activation via an ERK2 pathway in virus-infected human embryonic kidney cells.

1 reference

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Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells

1 reference

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14 September 2017

The MC160 protein expressed by the dermatotropic poxvirus molluscum contagiosum virus prevents tumor necrosis factor alpha-induced NF-kappaB activation via inhibition of I kappa kinase complex formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

14 September 2017

Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway

1 reference

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The two NF-kappaB activation pathways and their role in innate and adaptive immunity

1 reference

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14 September 2017

The vaccinia virus K1L gene product inhibits host NF-kappaB activation by preventing IkappaBalpha degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

14 September 2017

The Human Herpes Virus 8-Encoded Viral FLICE-inhibitory Protein Induces Cellular Transformation via NF-κB Activation

1 reference

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14 September 2017

Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases

1 reference

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14 September 2017

Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression

1 reference

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Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways

1 reference

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14 September 2017

TNF-R1 signaling: a beautiful pathway

1 reference

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14 September 2017

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

1 reference

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14 September 2017

TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

14 September 2017

FLASH coordinates NF-kappa B activity via TRAF2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

14 September 2017

Immune-defense molecules of molluscum contagiosum virus, a human poxvirus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

14 September 2017

Activation of the NF-kappaB pathway by caspase 8 and its homologs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

14 September 2017

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

14 September 2017

Activation of NF-kappaB by FADD, Casper, and caspase-8.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

14 September 2017

Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

14 September 2017

IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

14 September 2017

IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

14 September 2017

IKK1-deficient mice exhibit abnormal development of skin and skeleton

1 reference

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14 September 2017

Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog

1 reference

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14 September 2017

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

14 September 2017

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

1 reference

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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14 September 2017

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

1 reference

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14 September 2017

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

1 reference

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14 September 2017

Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alpha

1 reference

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

1 reference

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Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

1 reference

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14 September 2017

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

1 reference

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Epigenetic inactivation of IkappaB Kinase-alpha in oral carcinomas and tumor progression

1 reference

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14 September 2017

Signal responsiveness of IkappaB kinases is determined by Cdc37-assisted transient interaction with Hsp90.

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

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Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655573

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Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.

1 reference

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Ultraviolet-induced cell death blocked by a selenoprotein from a human dermatotropic poxvirus.

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Limb and skin abnormalities in mice lacking IKKalpha

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The genome of molluscum contagiosum virus: analysis and comparison with other poxviruses

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Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes

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Expression of Toll-like receptors in verruca and molluscum contagiosum

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Genital HPV lesions and molluscum contagiosum occurring in patients receiving anti-TNF-alpha therapy.

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The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

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1 reference

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A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

1 reference

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Multiple bilateral eyelid molluscum contagiosum lesions associated with TNFalpha-antibody and methotrexate therapy

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3 September 2018

Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.

1 reference

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3 September 2018

Molluscum contagiosum virus inhibitors of apoptosis: The MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein

1 reference

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3 September 2018

Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19158250

12 December 2020

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Identifiers

10.1128/JVI.02009-08

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19158250%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19158250%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19158250%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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