(Q37136020)

English

Probing the role of parasite-specific, distant structural regions on communication and catalysis in the bifunctional thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum

scientific article published on 12 January 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Probing the role of parasite-specific, distant structural regions on communication and catalysis in the bifunctional thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Plasmodium falciparum

0 references

author name string

Tina Dasgupta

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Karen S Anderson

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

language of work or name

0 references

publication date

12 January 2008

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

47

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

5

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

1336-1345

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Compensating enthalpic and entropic changes hinder binding affinity optimization

1 reference

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14 September 2017

Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

14 September 2017

Designing ligands to bind proteins

1 reference

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14 September 2017

Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment

1 reference

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14 September 2017

Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

14 September 2017

Structure, dynamics, and catalytic function of dihydrofolate reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

14 September 2017

Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

14 September 2017

Correlated motion and the effect of distal mutations in dihydrofolate reductase

1 reference

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14 September 2017

Insights into antifolate resistance from malarial DHFR-TS structures

1 reference

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14 September 2017

Essential protein-protein interactions between Plasmodium falciparum thymidylate synthase and dihydrofolate reductase domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

14 September 2017

Non-active site changes elicit broad-based cross-resistance of the HIV-1 protease to inhibitors

1 reference

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14 September 2017

PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists.

1 reference

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14 September 2017

Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation

1 reference

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14 September 2017

Bifunctional thymidylate synthase-dihydrofolate reductase in protozoa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

14 September 2017

Thymidylate synthase-dihydrofolate reductase in protozoa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

14 September 2017

The crystal structure of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveals a novel architecture for the bifunctional enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

14 September 2017

In vitro activities of the biguanide PS-15 and its metabolite, WR99210, against cycloguanil-resistant Plasmodium falciparum isolates from Thailand.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

14 September 2017

Stereochemistry of a multistep/bipartite methyl transfer reaction: thymidylate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

29 September 2017

Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

29 September 2017

Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

27 June 2018

Role of solvation barriers in protein kinetic stability.

1 reference

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3 September 2018

Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

3 September 2018

Kinetic characterization of bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) from Cryptosporidium hominis: a paradigm shift for ts activity and channeling behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

3 September 2018

Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658879

3 September 2018

A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance

1 reference

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3 September 2018

Basis for antifolate action and resistance in malaria.

1 reference

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3 September 2018

Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase

1 reference

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3 September 2018

Pentamidine: a review

1 reference

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4 December 2018

Folate coenzymes of Clostridium acidi-urici. The isolation of (l)-5,10-methenyltetrahydropteroyltriglutamate, its conversion to (l)-tetrahydropteroyltriglutamate and (l)-10-( 14 C)formyltetrahydropteroyltriglutamate, and the synthesis of (l)-10-form

1 reference

https://pubmed.ncbi.nlm.nih.gov/18189414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate channeling and domain-domain interactions in bifunctional thymidylate synthase-dihydrofolate reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18189414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymic preparation of the 1,L-diastereoisomer of tetrahydrofolic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/18189414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/18189414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18189414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI701624U

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

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