(Q37138955)

English

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors

scientific article published on 14 December 2015

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scholarly article

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2 March 2020

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors (English)

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2 March 2020

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Timothy R Hercus

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Michael W Parker

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2 March 2020

author name string

Con Panousis

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Kirsten M Edwards

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Veronika Rayzman

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Matthew P Hardy

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Hal Braley

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Gail M Gauvreau

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Roma Sehmi

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2 March 2020

Laura McMillan

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2 March 2020

Mara Dottore

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Barbara J McClure

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Gino Vairo

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Andrew D Nash

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2 March 2020

Nicholas J Wilson

19

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2 March 2020

Michael J Wilson

20

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2 March 2020

Catherine M Owczarek

21

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2 March 2020

Steven Smith

9

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14 December 2015

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2 March 2020

Monoclonal Antibodies

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2 March 2020

8

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2 March 2020

3

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2 March 2020

436-453

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2 March 2020

Evidence for the efficacy and safety of anti-interleukin-5 treatment in the management of refractory eosinophilic asthma

1 reference

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14 September 2017

GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential.

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14 September 2017

Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells

1 reference

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14 September 2017

Clinical heterogeneity in the severe asthma research program

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Profile of reslizumab in eosinophilic disease and its potential in the treatment of poorly controlled eosinophilic asthma

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Novel targeted therapies for eosinophilic disorders

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Protein engineering and preclinical development of a GM-CSF receptor antibody for the treatment of rheumatoid arthritis

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Natural-source d-α-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivo

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14 September 2017

The GM-CSF receptor family: mechanism of activation and implications for disease

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Benralizumab--a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity--a novel approach for the treatment of asthma

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Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program

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Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-α, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study

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Pharmacokinetics and pharmacodynamics of mepolizumab, an anti-interleukin-5 monoclonal antibody

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Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1

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14 September 2017

Haemopoietic processes in allergic disease: eosinophil/basophil development

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14 September 2017

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

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14 September 2017

In vitro effects of budesonide on eosinophil-basophil lineage commitment

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14 September 2017

Mepolizumab and exacerbations of refractory eosinophilic asthma

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14 September 2017

Granulocyte-macrophage colony-stimulating factor expression in induced sputum and bronchial mucosa in asthma and COPD

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14 September 2017

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

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An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope

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Hemopoietic Progenitor Cells and Hemopoietic Factors: Potential Targets for Treatment of Allergic Inflammatory Diseases

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IL-5-induced airway eosinophilia--the key to asthma?

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14 September 2017

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14 September 2017

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14 September 2017

Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation

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Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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29 September 2017

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27 June 2018

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27 June 2018

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27 June 2018

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27 June 2018

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3 September 2018

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3 September 2018

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3 September 2018

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3 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966837

3 September 2018

Profiles of proinflammatory cytokines in sputum from different groups of severe asthmatic patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966837

3 September 2018

Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966837

3 September 2018

Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966837

3 September 2018

Differential regulation of human eosinophil IL-3, IL-5, and GM-CSF receptor alpha-chain expression by cytokines: IL-3, IL-5, and GM-CSF down-regulate IL-5 receptor alpha expression with loss of IL-5 responsiveness, but up-regulate IL-3 receptor alph

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966837

3 September 2018

Anti–IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966837

3 September 2018

Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966837

3 September 2018

Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966837

3 September 2018

Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/26651396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An inhaled corticosteroid, budesonide, reduces baseline but not allergen-induced increases in bone marrow inflammatory cell progenitors in asthmatic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/26651396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous antagonism of interleukin-5, granulocyte-macrophage colony-stimulating factor, and interleukin-3 stimulation of human eosinophils by targetting the common cytokine binding site of their receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26651396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-interleukin-5 monoclonal antibody to treat severe eosinophilic asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26651396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-5 deficiency abolishes aspects of airway remodelling in a murine model of lung inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26651396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

1 reference

https://pubmed.ncbi.nlm.nih.gov/26651396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-response effects of TPI ASM8 in asthmatics after allergen

1 reference

https://pubmed.ncbi.nlm.nih.gov/26651396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delayed eosinophil apoptosis in asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26651396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting of eosinophils in asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26651396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IL-3/IL-5/GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26651396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of inhaled interleukin-5 on airway hyperreactivity and eosinophilia in asthmatics

1 reference

https://pubmed.ncbi.nlm.nih.gov/26651396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Novel Functional Epitope Formed by Domains 1 and 4 of the Human Common β-Subunit Is Involved in Receptor Activation by Granulocyte Macrophage Colony-stimulating Factor and Interleukin 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/26651396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26651396

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1080/19420862.2015.1119352

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26651396%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26651396%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26651396%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

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