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The Roles of SIRT1 in Cancer
scientific article published on March 2013
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
3764469
retrieved
18 August 2017
title
The Roles of SIRT1 in Cancer
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3764469
retrieved
18 August 2017
author name string
Zhenghong Lin
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3764469
retrieved
18 August 2017
Deyu Fang
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
3764469
retrieved
18 August 2017
publication date
1 March 2013
1 reference
stated in
Europe PubMed Central
PMCID
3764469
retrieved
18 August 2017
published in
Genes & Cancer
1 reference
stated in
Europe PubMed Central
PMCID
3764469
retrieved
18 August 2017
volume
4
1 reference
stated in
Europe PubMed Central
PMCID
3764469
retrieved
18 August 2017
issue
3-4
1 reference
stated in
Europe PubMed Central
PMCID
3764469
retrieved
18 August 2017
page(s)
97-104
1 reference
stated in
Europe PubMed Central
PMCID
3764469
retrieved
18 August 2017
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6 September 2017
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Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3
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6 September 2017
Regulation of the aging process by autophagy
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6 September 2017
SIRT1: regulation of longevity via autophagy
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6 September 2017
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
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The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling
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Inhibition of transcriptional activity of c-JUN by SIRT1.
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PTEN acetylation modulates its interaction with PDZ domain
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Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells
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6 September 2017
Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription
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6 September 2017
SIRT1 regulates the function of the Nijmegen breakage syndrome protein
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6 September 2017
The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation
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6 September 2017
SIRT1 promotes DNA repair activity and deacetylation of Ku70
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6 September 2017
Histone deacetylase inhibitors synergize p300 autoacetylation that regulates its transactivation activity and complex formation
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6 September 2017
Phosphorylation of HuR by Chk2 regulates SIRT1 expression
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6 September 2017
SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
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6 September 2017
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging
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6 September 2017
SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity
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6 September 2017
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
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6 September 2017
Therapeutic potential of resveratrol: the in vivo evidence
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6 September 2017
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
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6 September 2017
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
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6 September 2017
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
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6 September 2017
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation
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6 September 2017
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
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6 September 2017
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
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6 September 2017
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6 September 2017
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
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6 September 2017
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6 September 2017
Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction
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6 September 2017
Convergence of Wnt, beta-catenin, and cadherin pathways
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6 September 2017
Mammalian SIRT1 represses forkhead transcription factors
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6 September 2017
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
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6 September 2017
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6 September 2017
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6 September 2017
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
Acetylation of beta-catenin by CREB-binding protein (CBP).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
Negative control of p53 by Sir2alpha promotes cell survival under stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
Duration of nuclear NF-kappaB action regulated by reversible acetylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
Genome maintenance mechanisms for preventing cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
TGFbeta signaling in growth control, cancer, and heritable disorders
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
TGF-beta signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
Cancer. p53, guardian of the genome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
6 September 2017
SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
14 September 2017
Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
14 September 2017
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
14 September 2017
Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
14 September 2017
Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
14 September 2017
Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
14 September 2017
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
14 September 2017
Radiobiologic response of medulloblastoma cell lines: involvement of beta-catenin?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
14 September 2017
p53 Activation: a case against Sir.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
14 September 2017
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
14 September 2017
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
14 September 2017
Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
14 September 2017
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
29 September 2017
USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
3 September 2018
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
3 September 2018
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
3 September 2018
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
3 September 2018
Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764469
retrieved
4 December 2018
Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24020000
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
SIRT1 regulates CD40 expression induced by TNF-α via NF-ĸB pathway in endothelial cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24020000
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A role for SIRT1 in the hypoxic response
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24020000
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1177/1947601912475079
1 reference
stated in
Europe PubMed Central
PMCID
3764469
retrieved
18 August 2017
PMCID
3764469
1 reference
stated in
Europe PubMed Central
PMCID
3764469
retrieved
18 August 2017
PubMed ID
24020000
1 reference
stated in
Europe PubMed Central
PMCID
3764469
retrieved
18 August 2017
ResearchGate publication ID
256477585
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