(Q35123468)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12736103%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

review article

1 reference

title

Improving cancer therapy by non-genotoxic activation of p53 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12736103%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12736103%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

author name string

S Lain

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12736103%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

publication date

1 May 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12736103%20AND%20SRC:MED&resulttype=core&format=json

European Journal of Cancer

3 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12736103%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

volume

39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12736103%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

page(s)

1053-1060

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12736103%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12736103%20AND%20SRC:MED&resulttype=core&format=json

Therapeutic exploitation of the p53 pathway

3 November 2019

cites work

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7 January 2021

Rescuing the function of mutant p53.

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7 January 2021

Cancer gene therapy: fringe or cutting edge?

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7 January 2021

T antigen is bound to a host protein in SY40-transformed cells

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7 January 2021

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

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7 January 2021

Mutations in the p53 gene occur in diverse human tumour types

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7 January 2021

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

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7 January 2021

The p53 proto-oncogene can act as a suppressor of transformation

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7 January 2021

Wild-type p53 can inhibit oncogene-mediated focus formation

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7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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7 January 2021

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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7 January 2021

p53 Website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis

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7 January 2021

Tumor-suppressor p53: implications for tumor development and prognosis

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7 January 2021

Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy

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7 January 2021

p53 gene status and response to platinum/paclitaxel-based chemotherapy in advanced ovarian carcinoma

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7 January 2021

The cellular response to p53: the decision between life and death

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7 January 2021

Live or let die: the cell's response to p53

1 reference

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7 January 2021

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Additive effect between NF-kappaB subunits and p53 protein for transcriptional activation of human p53 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

A unique, short sequence determines p53 gene basal and UV-inducible expression in normal human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

mdm2 expression is induced by wild type p53 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Functions of the MDM2 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Tumor surveillance via the ARF-p53 pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Mammalian G1- and S-phase checkpoints in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

The role of PML in tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Nucleophosmin regulates the stability and transcriptional activity of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Viruses in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Viruses in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Ubiquitin, E6-AP, and their role in p53 inactivation.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Adenovirus and cell cycle control

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Transcriptional repression of the human p53 gene by hepatitis B viral X protein

1 reference

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7 January 2021

p53 inhibition by the LANA protein of KSHV protects against cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Multiple viral strategies of HTLV-1 for dysregulation of cell growth control

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Regulation of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Hypophosphorylation of Mdm2 augments p53 stability

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Novel targets of Akt, p21(Cipl/WAF1), and MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

SUMO-1 modification activates the transcriptional response of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Why is p53 acetylated?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Heat-induced p53-dependent signal transduction and its role in hyperthermic cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Genotoxic and non-genotoxic pathways of p53 induction

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Accumulating active p53 in the nucleus by inhibition of nuclear export: a novel strategy to promote the p53 tumor suppressor function

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

A concomitant ATP-depleting strategy markedly enhances anticancer agent activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

The INK4a/ARF network in tumour suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

E2F-1 induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Mechanisms of p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Prevention of fluorodeoxyuridine-induced cytotoxicity and DNA damage in HT29 colon carcinoma cells by conditional expression of wild-type p53 phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Role for p53 in the recovery of transcription and protection against apoptosis induced by ultraviolet light

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Oxidants, oxidative stress and the biology of ageing

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Cell-cycle arrest versus cell death in cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

p53 mutant mice that display early ageing-associated phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Tumor suppressor genes in normal and malignant hematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Curable and non-curable malignancies: lessons from paediatric cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Developing strategies for long term follow up of survivors of childhood cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Fertility and progeny.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

The quality of survival after childhood cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Growth and endocrine function after chemotherapy and radiotherapy in childhood.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

1 reference

7 January 2021

A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Development of the proteasome inhibitor PS-341.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Nuclear export inhibitor leptomycin B induces the appearance of novel forms of human Mdm2 protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Phase I trial of elactocin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

The human papillomavirus E6 protein and its contribution to malignant progression

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Role of the human papilloma virus in the development of cervical intraepithelial neoplasia and malignancy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

The role of human papillomavirus vaccines in cervical neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Chemotherapy of advanced and recurrent cervical carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

Activation of p53 in cervical carcinoma cells by small molecules.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900063-7

7 January 2021

10.1016/S0959-8049(03)00063-7

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12736103%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference