(Q37150550)

English

The role of peroxisome proliferator-activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus

scientific article published on December 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

The role of peroxisome proliferator-activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

type 2 diabetes

0 references

0 references

author name string

D Gupta

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

T Kono

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

C Evans-Molina

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

publication date

1 December 2010

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Europe PubMed Central

PMC publication ID

18 August 2017

Diabetes, Obesity and Metabolism

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

1036-1047

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Regulation of insulin secretion: role of mitochondrial signalling

1 reference

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6 September 2017

The effect of multiple genetic variants in predicting the risk of type 2 diabetes

1 reference

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6 September 2017

Effect of Rosiglitazone and Ramipril on {beta}-cell function in people with impaired glucose tolerance or impaired fasting glucose: the DREAM trial

1 reference

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Computational identification and experimental validation of PPRE motifs in NHE1 and MnSOD genes of human

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6 September 2017

TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.

1 reference

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6 September 2017

Molecular mechanism by which pioglitazone preserves pancreatic beta-cells in obese diabetic mice: evidence for acute and chronic actions as a PPARgamma agonist

1 reference

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6 September 2017

Peroxisome proliferator-activated receptor gamma (PPARgamma): Is the genomic activity the only answer?

1 reference

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Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

1 reference

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Pathomechanisms of type 2 diabetes genes

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Beta-cell deterioration during diabetes: what's in the gun?

1 reference

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6 September 2017

Endoplasmic reticulum stress in beta-cells and development of diabetes

1 reference

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6 September 2017

Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress

1 reference

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6 September 2017

Failure of beta-cell adaptation in type 2 diabetes: Lessons from animal models

1 reference

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Insulin granule biogenesis, trafficking and exocytosis

1 reference

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6 September 2017

Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure

1 reference

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6 September 2017

Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress

1 reference

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6 September 2017

Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasis

1 reference

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6 September 2017

The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress.

1 reference

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6 September 2017

Metabolic cycling in control of glucose-stimulated insulin secretion

1 reference

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6 September 2017

Molecular physiology of mammalian glucokinase

1 reference

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6 September 2017

In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter

1 reference

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6 September 2017

Research resource: nuclear hormone receptor expression in the endocrine pancreas

1 reference

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6 September 2017

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

1 reference

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6 September 2017

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?

1 reference

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6 September 2017

Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1

1 reference

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6 September 2017

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

1 reference

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6 September 2017

Evidence for pancreatic beta-cell dysfunction in brothers of women with polycystic ovary syndrome

1 reference

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6 September 2017

The role for endoplasmic reticulum stress in diabetes mellitus

1 reference

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6 September 2017

Selective modulation of promoter recruitment and transcriptional activity of PPARgamma

1 reference

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6 September 2017

Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice

1 reference

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6 September 2017

The non-genomic crosstalk between PPAR-gamma ligands and ERK1/2 in cancer cell lines

1 reference

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6 September 2017

A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis

1 reference

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6 September 2017

Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats

1 reference

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6 September 2017

The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging

1 reference

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6 September 2017

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

1 reference

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6 September 2017

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

1 reference

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6 September 2017

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

1 reference

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6 September 2017

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

1 reference

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TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population

1 reference

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Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment

1 reference

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6 September 2017

A genome-wide association study identifies novel risk loci for type 2 diabetes

1 reference

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6 September 2017

Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells

1 reference

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6 September 2017

Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy

1 reference

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6 September 2017

Regulation of insulin secretion by uncoupling protein

1 reference

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6 September 2017

Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial

1 reference

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6 September 2017

Islet beta cell failure in type 2 diabetes

1 reference

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6 September 2017

Thiazolidinedione use and bone loss in older diabetic adults

1 reference

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Genome-wide identification of peroxisome proliferator response elements using integrated computational genomics

1 reference

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6 September 2017

Regulation of the insulin gene by glucose and fatty acids

1 reference

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6 September 2017

Effect of pioglitazone on pancreatic beta-cell function and diabetes risk in Hispanic women with prior gestational diabetes

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6 September 2017

RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

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6 September 2017

Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus

1 reference

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6 September 2017

Dysfunctional fat cells, lipotoxicity and type 2 diabetes

1 reference

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6 September 2017

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans

1 reference

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6 September 2017

Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?

1 reference

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6 September 2017

The peroxisome proliferator-activated receptor-gamma regulates murine pyruvate carboxylase gene expression in vivo and in vitro

1 reference

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6 September 2017

Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter

1 reference

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6 September 2017

Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program

1 reference

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6 September 2017

Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes

1 reference

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6 September 2017

ER stress and the unfolded protein response

1 reference

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6 September 2017

Metabolic regulation of the pancreatic beta-cell ATP-sensitive K+ channel: a pas de deux

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Thiazolidinediones

1 reference

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6 September 2017

MAP kinases and their roles in pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Expression and functional activity of PPARgamma in pancreatic beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Uncoupling protein 2 and islet function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.

1 reference

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6 September 2017

A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Regulation of insulin gene transcription

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

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6 September 2017

Lessons from the glitazones: a story of drug development

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6 September 2017

Dual DNA-binding specificity of peroxisome-proliferator-activated receptor gamma controlled by heterodimer formation with retinoid X receptor alpha

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6 September 2017

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Diabetes incidence and prevalence in Pima Indians: a 19-fold greater incidence than in Rochester, Minnesota

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

6 September 2017

Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

14 September 2017

Involvement of PDX-1 in activation of human insulin gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

14 September 2017

ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

14 September 2017

Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

29 September 2017

Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

29 September 2017

Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

29 September 2017

Trans-acting factor(s) confer glucose-responsive transcriptional regulation in the insulin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

29 September 2017

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

29 September 2017

Obesity and the beta cell: lessons from leptin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

29 September 2017

Combining a dipeptidyl peptidase-4 inhibitor, alogliptin, with pioglitazone improves glycaemic control, lipid profiles and beta-cell function in db/db mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

27 June 2018

Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

27 June 2018

An increase in insulin sensitivity and basal beta-cell function in diabetic subjects treated with pioglitazone in a placebo-controlled randomized study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

27 June 2018

PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

27 June 2018

Troglitazone-induced hepatic failure leading to liver transplantation. A case report

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

27 June 2018

TRIPOD (TRoglitazone In the Prevention Of Diabetes): a randomized, placebo-controlled trial of troglitazone in women with prior gestational diabetes mellitus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

27 June 2018

Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

27 June 2018

Troglitazone enhances differentiation, basal glucose uptake, and Glut1 protein levels in 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

27 June 2018

CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

27 June 2018

Inhibitory effects of thiazolidinedione upon cytokine-induced apoptosis in pancreatic beta-cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

The risk allele load accelerates the age-dependent decline in beta cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Mary, Mary, quite contrary, how do your beta-cells fail?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

PPARgamma-dependent and -independent effects of rosiglitazone on lipotoxic human pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Thiazolidinediones and cardiovascular outcomes in older patients with diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Pioglitazone attenuates fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Thiazolidinediones improve beta-cell function in type 2 diabetic patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Pioglitazone improves insulin secretory capacity and prevents the loss of beta-cell mass in obese diabetic db/db mice: Possible protection of beta cells from oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Influence of rosiglitazone treatment on beta-cell function in type 2 diabetes: evidence of an increased ability of glucose to entrain high-frequency insulin pulsatility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Rosiglitazone reverses insulin secretion altered by chronic exposure to free fatty acid via IRS-2-associated phosphatidylinositol 3-kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

The pancreatic homeodomain transcription factor IDX1/IPF1 is expressed in neural cells during brain development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Troglitazone regulation of glucose metabolism in human skeletal muscle cultures from obese type II diabetic subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Effect of troglitazone on B cell function, insulin sensitivity, and glycemic control in subjects with type 2 diabetes mellitus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764483

3 September 2018

Insulitis in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20977574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose activates both K(ATP) channel-dependent and K(ATP) channel-independent signaling pathways in human islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/20977574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of peroxisome proliferator-activated receptor γ (PPARγ) in normal human pancreatic islet cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20977574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-stimulated insulin biosynthesis depends on insulin-stimulated insulin gene transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/20977574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20977574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type

1 reference

https://pubmed.ncbi.nlm.nih.gov/20977574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B

1 reference

https://pubmed.ncbi.nlm.nih.gov/20977574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1463-1326.2010.01299.X

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

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